Between 1960 and 1970, the Baltimore Orioles had the highest run differential by a team in a season, with a differential of 262 runs in 1969.
| TEAM | DIFF | SEASON | G | W% | W | L | AB | R | H | 2B | 3B | HR | RBI | BB | HBP | SO | SB | CS | PA | TB | XBH | SH | SF | IBB | GIDP | AVG | OBP | SLG | OPS | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Orioles | 262 | 1969 | 162 | .673 | 109 | 53 | 5,518 | 779 | 1,465 | 234 | 29 | 175 | 722 | 634 | 43 | 806 | 82 | 45 | 6,328 | 2,282 | 438 | 74 | 59 | 62 | 138 | .265 | .343 | .414 | .756 |
| 2 | | Orioles | 218 | 1970 | 162 | .667 | 108 | 54 | 5,545 | 792 | 1,424 | 213 | 25 | 179 | 748 | 717 | 44 | 952 | 84 | 39 | 6,416 | 2,224 | 417 | 64 | 46 | 64 | 110 | .257 | .344 | .401 | .745 |
| 3 |  | Yankees | 215 | 1961 | 163 | .673 | 109 | 53 | 5,559 | 827 | 1,461 | 194 | 40 | 240 | 781 | 543 | 35 | 785 | 28 | 18 | 6,239 | 2,455 | 474 | 57 | 45 | 45 | 120 | .263 | .330 | .442 | .771 |
| 4 |  | Giants | 188 | 1962 | 165 | .624 | 103 | 62 | 5,588 | 878 | 1,552 | 235 | 32 | 204 | 807 | 523 | 42 | 822 | 73 | 50 | 6,277 | 2,463 | 471 | 76 | 48 | 41 | 120 | .278 | .341 | .441 | .782 |
| 5 |  | Tigers | 179 | 1968 | 164 | .636 | 103 | 59 | 5,490 | 671 | 1,292 | 190 | 39 | 185 | 639 | 521 | 61 | 964 | 26 | 32 | 6,179 | 2,115 | 414 | 73 | 34 | 53 | 124 | .235 | .307 | .385 | .692 |
| 6 |  | Twins | 174 | 1965 | 162 | .630 | 102 | 60 | 5,488 | 774 | 1,396 | 257 | 42 | 150 | 711 | 554 | 35 | 969 | 92 | 33 | 6,213 | 2,187 | 449 | 77 | 59 | 79 | 93 | .254 | .324 | .399 | .722 |
| 7 | | Twins | 172 | 1969 | 162 | .599 | 97 | 65 | 5,677 | 790 | 1,520 | 246 | 32 | 163 | 733 | 599 | 43 | 906 | 115 | 70 | 6,424 | 2,319 | 441 | 65 | 40 | 78 | 114 | .268 | .340 | .408 | .748 |
| 8 | | Tigers | 170 | 1961 | 163 | .623 | 101 | 61 | 5,561 | 841 | 1,481 | 215 | 53 | 180 | 779 | 673 | 38 | 865 | 98 | 36 | 6,378 | 2,342 | 448 | 64 | 42 | 39 | 125 | .266 | .347 | .421 | .768 |
| 9 | | Yankees | 167 | 1963 | 161 | .646 | 104 | 57 | 5,506 | 714 | 1,387 | 197 | 35 | 188 | 666 | 434 | 31 | 808 | 42 | 26 | 6,067 | 2,218 | 420 | 66 | 30 | 46 | 91 | .252 | .309 | .403 | .711 |
| 10 | | Twins | 165 | 1963 | 161 | .565 | 91 | 70 | 5,531 | 767 | 1,408 | 223 | 35 | 225 | 722 | 547 | 41 | 912 | 32 | 14 | 6,233 | 2,376 | 483 | 84 | 30 | 41 | 116 | .255 | .325 | .430 | .754 |
| 11 | | Orioles | 154 | 1966 | 160 | .606 | 97 | 63 | 5,529 | 755 | 1,426 | 243 | 35 | 175 | 703 | 514 | 39 | 926 | 55 | 43 | 6,199 | 2,264 | 453 | 82 | 35 | 59 | 119 | .258 | .324 | .409 | .733 |
| 12 | | Yankees | 153 | 1964 | 164 | .611 | 99 | 63 | 5,705 | 730 | 1,442 | 208 | 35 | 162 | 688 | 520 | 31 | 976 | 54 | 18 | 6,358 | 2,206 | 405 | 68 | 34 | 64 | 117 | .253 | .317 | .387 | .704 |
| 13 |  | Dodgers | 145 | 1962 | 165 | .618 | 102 | 63 | 5,628 | 842 | 1,510 | 192 | 65 | 140 | 781 | 572 | 32 | 886 | 198 | 43 | 6,362 | 2,252 | 397 | 83 | 47 | 65 | 126 | .268 | .337 | .400 | .737 |
| 14 |  | White Sox | 141 | 1964 | 162 | .605 | 98 | 64 | 5,491 | 642 | 1,356 | 184 | 40 | 106 | 586 | 562 | 52 | 902 | 75 | 39 | 6,246 | 1,938 | 330 | 96 | 45 | 58 | 100 | .247 | .320 | .353 | .673 |
| 15 |  | Pirates | 141 | 1960 | 155 | .617 | 95 | 59 | 5,406 | 734 | 1,493 | 236 | 56 | 120 | 689 | 486 | 20 | 747 | 34 | 24 | 6,029 | 2,201 | 412 | 69 | 48 | 71 | 119 | .276 | .335 | .407 | .743 |
| 16 | | Twins | 139 | 1970 | 162 | .605 | 98 | 64 | 5,483 | 744 | 1,438 | 230 | 41 | 153 | 694 | 501 | 42 | 905 | 57 | 52 | 6,143 | 2,209 | 424 | 79 | 38 | 65 | 132 | .262 | .327 | .403 | .730 |
| 17 | | White Sox | 139 | 1963 | 162 | .580 | 94 | 68 | 5,508 | 683 | 1,379 | 208 | 40 | 114 | 648 | 571 | 40 | 896 | 64 | 28 | 6,242 | 2,009 | 362 | 79 | 44 | 29 | 97 | .250 | .323 | .365 | .688 |
| 18 |  | Cardinals | 138 | 1967 | 161 | .627 | 101 | 60 | 5,566 | 695 | 1,462 | 225 | 40 | 115 | 656 | 443 | 45 | 919 | 102 | 54 | 6,152 | 2,112 | 380 | 54 | 44 | 77 | 105 | .263 | .320 | .379 | .699 |
| 19 | | Yankees | 137 | 1962 | 162 | .593 | 96 | 66 | 5,644 | 817 | 1,509 | 240 | 29 | 199 | 791 | 584 | 32 | 842 | 42 | 29 | 6,393 | 2,404 | 468 | 79 | 54 | 46 | 123 | .267 | .337 | .426 | .762 |
| 20 |  | Cubs | 127 | 1970 | 162 | .519 | 84 | 78 | 5,491 | 806 | 1,424 | 228 | 44 | 179 | 761 | 607 | 20 | 844 | 39 | 16 | 6,229 | 2,277 | 451 | 75 | 36 | 65 | 110 | .259 | .333 | .415 | .748 |
| 21 | | White Sox | 124 | 1960 | 154 | .565 | 87 | 67 | 5,191 | 741 | 1,402 | 242 | 38 | 112 | 684 | 567 | 54 | 648 | 122 | 48 | 5,966 | 2,056 | 392 | 95 | 59 | 36 | 133 | .270 | .345 | .396 | .741 |
| 22 |  | Reds | 121 | 1965 | 162 | .549 | 89 | 73 | 5,658 | 825 | 1,544 | 268 | 61 | 183 | 776 | 538 | 50 | 1,003 | 82 | 40 | 6,355 | 2,483 | 512 | 73 | 36 | 89 | 120 | .273 | .339 | .439 | .778 |
| 23 | | Cardinals | 119 | 1963 | 162 | .574 | 93 | 69 | 5,678 | 747 | 1,540 | 231 | 66 | 128 | 697 | 458 | 25 | 915 | 77 | 42 | 6,283 | 2,287 | 425 | 85 | 37 | 51 | 95 | .271 | .326 | .403 | .729 |
| 24 | | Yankees | 119 | 1960 | 155 | .630 | 97 | 57 | 5,290 | 746 | 1,377 | 215 | 40 | 193 | 699 | 537 | 28 | 818 | 37 | 23 | 5,981 | 2,251 | 448 | 81 | 45 | 41 | 112 | .260 | .329 | .426 | .755 |
| 25 | | Pirates | 118 | 1966 | 162 | .568 | 92 | 70 | 5,676 | 759 | 1,586 | 238 | 66 | 158 | 715 | 405 | 35 | 1,011 | 64 | 60 | 6,229 | 2,430 | 462 | 73 | 40 | 75 | 111 | .279 | .329 | .428 | .757 |
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| NL East | W | L | PCT | GB |
|---|---|---|---|---|
 Braves - y | 94 | 68 | .580 | |
 Phillies - w | 88 | 74 | .543 | 6.0 |
80 | 82 | .494 | 14.0 | |
77 | 85 | .475 | 17.0 | |
74 | 88 | .457 | 20.0 | |
| NL Central | W | L | PCT | GB |
 Brewers - y | 103 | 59 | .636 | |
 Cubs - w | 89 | 73 | .549 | 14.0 |
82 | 80 | .506 | 21.0 | |
77 | 85 | .475 | 26.0 | |
75 | 87 | .463 | 28.0 | |
| NL West | W | L | PCT | GB |
 Dodgers - y | 100 | 62 | .617 | |
 Padres - w | 91 | 71 | .562 | 9.0 |
86 | 76 | .531 | 14.0 | |
65 | 97 | .401 | 35.0 | |
58 | 104 | .358 | 42.0 |
Marlins
Nationals
Mets
Pirates
Cardinals
Reds
Diamondbacks
Giants
Rockies| AL East | W | L | PCT | GB |
|---|---|---|---|---|
 Rays - y | 98 | 64 | .605 | |
 Yankees - w | 93 | 68 | .578 | 4.5 |
 Red Sox - w | 87 | 75 | .537 | 11.0 |
79 | 82 | .491 | 18.5 | |
79 | 83 | .488 | 19.0 | |
| AL Central | W | L | PCT | GB |
 Guardians - y | 85 | 77 | .525 | |
 White Sox - w | 84 | 78 | .519 | 1.0 |
77 | 85 | .475 | 8.0 | |
76 | 86 | .469 | 9.0 | |
69 | 93 | .426 | 16.0 | |
| AL West | W | L | PCT | GB |
 Astros - y | 81 | 81 | .500 | |
80 | 82 | .494 | 1.0 | |
76 | 86 | .469 | 5.0 | |
64 | 98 | .395 | 17.0 | |
62 | 100 | .383 | 19.0 |
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Tigers
Royals
Rangers
Mariners
Athletics
Angels