The Arizona Diamondbacks and the Boston Americans were tied for the most wins in their first 4 seasons, with 342 wins.

Interpreted as:

team with most regular-season wins in first 4 seasons

	TEAM	W	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Diamondbacks	342	306	.528	648	22,271	3,183	5,879	1,090	171	762	3,018	2,199	228	4,311	378	159	25,117	9,597	2,023	238	181	194	438	.264	.334	.431	.765
2	Americans	342	223	.605	574	19,891	2,739	5,339	794	417	153	2,335	1,215	176	1,784	531		21,790	7,426	1,364	508				.268	.316	.373	.690
3	Highlanders	325	260	.556	598	19,837	2,405	5,072	717	291	85	1,981	1,335	235	2,084	715		22,011	6,626	1,093	604				.256	.310	.334	.644
4	Athletics	313	245	.561	566	19,405	2,734	5,280	898	299	136	2,326	1,225	162	1,743	668		21,233	7,184	1,333	441				.272	.321	.370	.691
5	Angels	308	338	.477	647	21,791	2,603	5,383	844	122	523	2,426	2,203	128	3,821	175	124	24,609	8,040	1,489	324	163	148	481	.247	.318	.369	.687
6	White Sox	306	255	.545	569	19,076	2,610	4,920	712	256	74	2,148	1,584	177	1,839	941		21,465	6,366	1,042	628				.258	.321	.334	.654
7	Royals	295	344	.462	640	21,427	2,380	5,292	826	139	353	2,230	2,060	123	3,389	441	213	24,009	7,455	1,318	237	162	193	513	.247	.314	.348	.662
8	Naps	286	277	.508	569	19,598	2,638	5,317	901	321	103	2,208	1,117	169	1,980	618		21,397	7,169	1,325	513				.271	.316	.366	.682
9	Rockies	280	305	.479	585	20,107	3,077	5,618	1,040	178	688	2,902	1,777	207	3,756	563	268	22,545	9,078	1,906	283	171	160	457	.279	.341	.451	.793
10	Giants	268	171	.610	450	15,975	2,606	4,194	613	287	83	991	834			155		16,809	5,630	983					.263		.352
11	Expos	266	375	.415	642	21,321	2,404	5,101	766	119	440	2,217	2,205	204	3,562	236	206	24,239	7,425	1,325	374	135	228	470	.239	.315	.348	.663
12	Devil Rays	263	384	.406	647	22,170	2,797	5,821	1,103	115	539	2,644	2,031	206	4,287	398	220	24,738	8,771	1,757	180	151	97	540	.263	.328	.396	.724
13	Brewers	263	378	.410	643	21,148	2,279	4,973	708	96	443	2,111	2,233	129	3,792	404	242	24,012	7,202	1,247	372	130	179	490	.235	.310	.341	.651
14	Marlins	262	320	.450	582	19,785	2,410	5,090	831	114	482	2,279	1,917	195	3,838	412	181	22,273	7,595	1,427	210	166	151	446	.257	.326	.384	.710
15	Astros	261	385	.404	648	21,728	2,120	5,067	690	169	334	1,944	1,832	163	3,493	211	145	24,162	7,097	1,193	305	134	166	489	.233	.296	.327	.623
16	Browns	256	308	.454	574	19,461	2,241	4,903	719	248	77	1,847	1,301	166	1,860	564		21,403	6,349	1,044	475				.252	.304	.326	.631
17	Tigers	253	305	.453	572	19,223	2,380	4,930	637	295	74	1,981	1,375	187	1,794	574		21,327	6,379	1,006	542				.256	.312	.332	.644
18	Browns	248	149	.625	400	14,284	2,283	3,520	488	204	46	450	642					15,014	4,554	738					.246	.283	.319	.602
19	Red Stockings	247	152	.619	402	14,816	2,547	3,839	434	294	101	451	548					15,467	5,164	829					.259	.290	.349	.639
20	Mariners	246	400	.381	647	21,851	2,559	5,574	908	157	466	2,400	1,946	104	2,923	475	228	24,410	8,194	1,531	316	193	136	520	.255	.316	.375	.691
21	Senators	239	407	.370	647	21,692	2,373	5,160	812	145	514	2,210	2,035	94	3,793	295	158	24,240	7,804	1,471	267	152	125	492	.238	.304	.360	.664
22	Padres	234	404	.367	638	21,430	2,123	4,987	740	147	469	1,959	1,768	114	4,249	253	180	23,721	7,428	1,356	316	93	181	464	.233	.293	.347	.640
23	Blue Jays	233	413	.361	646	21,843	2,432	5,485	949	167	419	2,246	1,843	115	2,940	235	235	24,230	8,025	1,535	286	143	122	530	.251	.311	.367	.678
24	Grays	229	258	.470	500	17,672	2,836	4,353	629	274	71	1,686	1,306	51		657		19,105	5,743	974					.246	.303	.325	.628
25	Metropolitans	226	220	.507	454	15,960	2,386	3,903	497	251	67	787	892			120		16,955	5,103	815					.245	.289	.320	.609