The San Francisco Giants have the most wins by a team with 40+ games played, with 11,564 wins.

Interpreted as:

team with most regular-season wins through 40 or more games

	TEAM	W	G	L	W%	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Giants	11,564	21,760	10,033	.535	742,661	100,631	195,355	31,336	7,035	15,577	90,105	68,264	5,673	99,486	16,513	3,142	831,274	287,492	53,948	11,664	3,012	4,016	10,176	.263	.329	.387	.716
2	Dodgers	11,456	21,675	10,080	.532	738,529	97,837	192,950	31,036	7,004	14,113	88,061	68,855	5,145	100,260	17,336	3,547	828,432	280,333	52,153	12,772	3,055	3,730	9,934	.261	.327	.380	.707
3	Cubs	11,349	22,292	10,782	.513	762,878	102,642	199,799	33,731	7,356	15,239	88,231	68,535	5,282	104,972	15,778	3,068	852,624	293,959	56,326	13,026	2,903	3,518	9,958	.262	.326	.385	.711
4	Braves	11,131	22,252	10,967	.504	761,862	99,458	197,871	32,093	6,298	15,045	86,507	67,461	5,062	100,043	14,089	3,063	849,940	287,695	53,436	12,681	2,874	3,652	10,374	.260	.323	.378	.701
5	Reds	10,952	21,876	10,785	.504	745,386	98,167	194,210	32,358	7,557	14,309	87,313	66,675	5,504	102,170	18,156	3,403	833,429	284,609	54,224	12,661	3,035	3,645	9,709	.261	.325	.382	.707
6	Pirates	10,851	21,835	10,844	.500	747,939	97,134	196,873	32,340	8,933	12,245	86,644	64,287	5,527	99,495	15,673	3,267	833,547	283,814	53,518	12,557	3,114	3,696	10,046	.263	.325	.379	.704
7	Yankees	10,798	19,050	8,164	.569	649,266	92,569	172,375	28,613	5,492	17,301	86,012	68,543	4,922	94,740	11,644	2,800	735,602	263,875	51,406	9,594	3,277	2,829	10,677	.265	.339	.406	.745
8	Cardinals	10,523	20,643	9,989	.513	706,117	92,353	187,646	31,809	7,049	12,850	84,418	64,159	5,193	98,069	15,010	3,613	790,575	272,103	51,708	11,971	3,135	3,775	10,128	.266	.330	.385	.715
9	Phillies	10,227	21,683	11,341	.474	741,924	96,280	193,195	33,394	6,677	14,179	86,505	67,705	5,410	105,245	14,951	2,912	829,964	282,480	54,250	11,914	3,011	3,739	9,858	.260	.326	.381	.706
10	Red Sox	9,973	19,338	9,282	.518	661,841	90,312	176,610	33,102	5,597	14,585	83,749	66,778	4,799	95,465	9,628	2,546	747,350	264,661	53,284	10,594	3,338	2,996	11,542	.267	.337	.400	.737
11	Guardians	9,873	19,348	9,384	.513	659,468	87,482	174,596	31,131	5,496	13,909	80,848	62,591	4,830	94,508	11,903	3,384	741,703	258,446	50,536	11,461	3,353	2,544	10,520	.265	.331	.392	.723
12	Tigers	9,698	19,371	9,580	.503	660,577	88,949	174,529	29,563	6,294	14,567	81,909	65,511	4,441	96,613	11,287	2,935	744,641	260,381	50,424	11,009	3,103	2,446	10,705	.264	.333	.394	.727
13	White Sox	9,604	19,345	9,638	.499	655,021	84,038	170,089	28,186	5,550	12,275	77,247	62,068	5,246	91,974	13,615	3,482	737,920	246,200	46,011	12,367	3,218	2,461	10,511	.260	.327	.376	.703
14	Athletics	9,349	19,311	9,875	.486	654,553	85,238	168,488	29,175	5,332	14,127	78,542	64,476	4,729	98,921	12,098	3,205	737,543	250,708	48,634	10,682	3,103	2,269	10,607	.257	.327	.383	.710
15	Twins	9,275	19,359	9,975	.482	660,408	85,120	173,199	29,741	6,331	12,001	78,364	62,327	5,153	94,371	12,008	3,078	741,240	251,605	48,073	10,189	3,163	2,661	10,964	.262	.329	.381	.710
16	Orioles	9,133	19,348	10,105	.475	657,195	83,546	169,582	29,305	4,909	14,421	77,243	63,251	4,471	98,232	10,540	2,778	738,545	251,968	48,635	10,530	3,098	2,574	10,832	.258	.326	.383	.709
17	Angels	5,034	10,172	5,135	.495	345,124	44,001	88,307	15,265	1,808	9,193	41,403	32,273	2,817	62,600	6,042	3,097	386,517	134,767	26,266	3,536	2,767	2,482	7,870	.256	.322	.390	.713
18	Astros	5,026	10,014	4,983	.502	339,842	42,702	86,626	15,884	2,171	8,411	40,187	32,312	2,894	62,833	7,146	3,130	381,787	132,085	26,466	4,028	2,711	3,144	7,397	.255	.323	.389	.711
19	Mets	4,839	10,008	5,161	.484	338,616	41,299	84,618	15,117	1,815	8,566	38,886	32,371	2,853	64,854	5,873	2,734	380,442	129,063	25,498	3,987	2,615	3,137	7,449	.250	.318	.381	.699
20	Rangers	4,836	10,162	5,320	.476	346,920	45,729	89,499	15,953	1,891	10,178	43,207	32,851	2,693	65,077	5,931	2,845	388,255	139,768	28,022	2,963	2,828	2,250	7,791	.258	.325	.403	.727
21	Brewers	4,327	8,879	4,548	.488	301,399	39,479	77,186	14,388	1,755	8,695	37,401	29,006	2,706	58,821	5,968	2,728	338,686	121,169	24,838	3,161	2,414	2,158	6,606	.256	.325	.402	.727
22	Nationals	4,282	8,875	4,589	.483	300,171	37,182	76,167	14,689	1,788	7,593	34,946	28,227	2,618	57,098	6,540	2,772	337,176	117,211	24,070	3,877	2,283	2,880	6,491	.254	.321	.390	.712
23	Royals	4,229	8,870	4,639	.477	303,388	38,800	79,670	14,894	2,284	6,998	36,618	25,979	2,456	52,045	7,081	2,893	336,854	120,126	24,176	2,365	2,666	1,865	6,773	.263	.323	.396	.719
24	Padres	4,150	8,881	4,729	.467	300,213	35,986	74,866	13,249	1,757	7,247	33,841	28,581	2,122	59,384	6,000	2,603	336,869	113,370	22,253	3,709	2,244	2,685	6,496	.249	.317	.378	.695
25	Blue Jays	3,777	7,586	3,806	.498	259,903	35,059	67,582	13,507	1,491	8,239	33,253	24,098	2,423	48,869	4,568	1,962	290,043	108,788	23,237	1,497	2,122	1,397	5,916	.260	.326	.419	.745