Randy Johnson has struck out the most hitters against right-handed batters in a season, with 341 strikeouts in 2001.
- Regular season
| NAME | SO | SEASON | TM | G | H | HR | BB | HBP | IBB | K/BB | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Johnson | 341 | 2001 | 35 | 160 | 18 | 62 | 10 | 2 | 5.50 | |
| 2 | | R. Johnson | 329 | 1999 | 35 | 198 | 30 | 62 | 6 | 3 | 5.31 | |
| 3 | | R. Johnson | 316 | 2000 | 35 | 183 | 23 | 68 | 3 | 1 | 4.65 | |
| 4 |  | R. Johnson | 289 | 1998 | TOT | 34 | 188 | 23 | 76 | 12 | 1 | 3.80 |
| 5 | | R. Johnson | 286 | 2002 | 35 | 165 | 21 | 60 | 6 | 1 | 4.77 | |
| 6 | | R. Johnson | 281 | 1993 | 35 | 172 | 22 | 95 | 13 | 1 | 2.96 | |
| 7 |  | C. Sale | 267 | 2017 | 32 | 140 | 21 | 37 | 7 | 0 | 7.22 | |
| 8 | | R. Johnson | 263 | 1997 | 30 | 127 | 16 | 71 | 7 | 2 | 3.70 | |
| 9 |  | S. Carlton | 247 | 1983 | 37 | 246 | 19 | 74 | 0 | 10 | 3.34 | |
| 10 | | R. Johnson | 245 | 1995 | 30 | 145 | 12 | 58 | 5 | 1 | 4.22 | |
| 11 | | R. Johnson | 244 | 2004 | 35 | 153 | 16 | 37 | 3 | 0 | 6.59 | |
| 12 | | S. Carlton | 240 | 1982 | 38 | 210 | 15 | 71 | 1 | 4 | 3.38 | |
| 13 | | S. Carlton | 233 | 1980 | 38 | 213 | 14 | 82 | 2 | 12 | 2.84 | |
| 14 |  | C. Sale | 225 | 2015 | 31 | 153 | 23 | 33 | 7 | 0 | 6.82 | |
| 15 |  | C. Kershaw | 224 | 2015 | 33 | 124 | 10 | 37 | 3 | 1 | 6.05 | |
| 16 | | R. Johnson | 222 | 1992 | 31 | 140 | 12 | 132 | 17 | 1 | 1.68 | |
| 17 |  | M. Langston | 220 | 1987 | 35 | 213 | 26 | 100 | 5 | 0 | 2.20 | |
| 18 | | J. Santana | 217 | 2004 | 34 | 118 | 19 | 44 | 8 | 0 | 4.93 | |
| 19 | | F. Tanana | 216 | 1975 | 33 | 177 | 20 | 65 | 5 | 6 | 3.32 | |
| 20 |  | D. Price | 210 | 2014 | TOT | 34 | 167 | 20 | 30 | 1 | 1 | 7.00 |
| 21 |  | G. Crochet | 209 | 2025 | 32 | 141 | 21 | 42 | 2 | 0 | 4.98 | |
| 22 | | J. Santana | 208 | 2006 | 34 | 143 | 18 | 35 | 3 | 0 | 5.94 | |
| 23 | | J.R. Richard | 207 | 1979 | 38 | 105 | 8 | 48 | 3 | 1 | 4.31 | |
| 24 | | R. Guidry | 205 | 1978 | 35 | 154 | 11 | 57 | 0 | 1 | 3.60 | |
| 25 |  | R. Ray | 203 | 2021 | 32 | 125 | 27 | 46 | 3 | 0 | 4.41 | |
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TORStatMuse has event-level data for strikeouts going back to the 1974 season.
Some of the information used here was obtained free of charge from Retrosheet.
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