Since 2010, the Miami Marlins have lost the most games by a team, with 1,347 losses.

Interpreted as:

teams with most regular-season losses since 2010

	TEAM	L	W	L%	G	W%	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Marlins	1,347	1,046	.563	2,393	.437	81,062	9,411	20,050	3,725	430	2,108	8,952	6,743	819	19,756	1,389	482	89,825	30,959	6,263	658	543	447	1,826	.247	.310	.382	.692
2	Rockies	1,344	1,053	.561	2,397	.439	82,000	11,088	21,400	4,259	602	2,659	10,606	7,006	687	20,139	1,258	507	90,974	34,840	7,520	684	597	476	1,752	.261	.322	.425	.747
3	White Sox	1,319	1,077	.551	2,396	.449	81,403	9,968	20,381	3,808	337	2,492	9,535	6,448	932	19,387	1,277	533	89,738	32,339	6,637	410	545	269	1,807	.250	.311	.397	.708
4	Royals	1,298	1,099	.542	2,397	.458	81,695	10,027	20,987	4,055	505	2,132	9,548	6,213	770	17,158	1,883	579	89,802	32,448	6,692	444	680	319	1,784	.257	.313	.397	.710
5	Pirates	1,282	1,115	.535	2,398	.465	80,797	9,713	19,800	3,915	466	2,193	9,270	7,277	924	19,690	1,331	575	90,202	31,226	6,574	639	565	458	1,683	.245	.313	.386	.699
6	Orioles	1,261	1,135	.526	2,396	.474	81,876	10,496	20,520	3,956	275	3,001	10,056	6,621	840	19,499	1,028	370	90,217	34,029	7,232	307	573	286	1,776	.251	.311	.416	.727
7	Reds	1,252	1,145	.522	2,397	.478	80,866	10,463	20,062	3,895	376	2,693	9,990	7,638	1,057	19,867	1,595	586	90,839	32,788	6,964	702	576	457	1,652	.248	.319	.405	.724
8	Diamondbacks	1,245	1,151	.520	2,396	.480	81,616	10,896	20,476	4,239	577	2,575	10,371	7,816	808	19,662	1,506	488	91,488	33,594	7,391	601	647	508	1,680	.251	.320	.412	.732
9	Twins	1,239	1,157	.517	2,396	.483	81,758	10,843	20,593	4,238	386	2,672	10,334	7,685	878	19,337	1,068	412	91,239	33,619	7,296	310	608	342	1,719	.252	.321	.411	.732
10	Padres	1,238	1,157	.517	2,395	.483	80,174	9,851	19,381	3,721	405	2,374	9,360	7,510	766	19,766	1,642	535	89,684	31,034	6,500	649	585	439	1,631	.242	.311	.387	.698
11	Tigers	1,236	1,157	.517	2,393	.483	81,714	10,384	20,949	4,052	509	2,405	9,953	7,046	719	19,471	991	406	90,411	33,234	6,966	307	625	400	1,833	.256	.319	.407	.725
12	Athletics	1,232	1,166	.514	2,398	.486	80,957	10,373	19,615	4,040	367	2,641	9,870	7,789	864	19,135	1,298	388	90,508	32,312	7,048	289	609	275	1,788	.242	.313	.399	.712
13	Angels	1,229	1,167	.513	2,396	.487	81,036	10,498	20,144	3,850	354	2,725	10,006	7,223	911	18,698	1,366	518	90,170	32,877	6,929	390	610	433	1,834	.249	.315	.406	.721
14	Mariners	1,224	1,171	.511	2,395	.489	80,804	9,921	19,397	3,666	294	2,657	9,479	7,470	962	20,264	1,444	515	90,121	31,622	6,617	341	544	318	1,613	.240	.310	.391	.701
15	Rangers	1,204	1,194	.502	2,398	.498	81,528	11,054	20,686	3,916	356	2,811	10,502	7,243	905	18,890	1,650	579	90,710	33,747	7,083	399	635	352	1,642	.254	.319	.414	.733
16	Nationals	1,199	1,197	.500	2,396	.500	80,926	10,552	20,532	4,052	363	2,563	10,037	7,539	903	18,758	1,602	513	90,670	32,999	6,978	685	617	505	1,746	.254	.322	.408	.730
17	Cubs	1,194	1,204	.498	2,399	.502	81,081	10,624	20,049	4,032	436	2,684	10,112	7,838	1,078	20,408	1,269	498	91,100	33,005	7,152	552	551	479	1,682	.247	.320	.407	.727
18	Mets	1,191	1,206	.497	2,397	.503	81,031	10,326	20,039	3,988	367	2,605	9,907	7,714	1,095	19,097	1,250	422	90,966	32,576	6,960	558	568	514	1,733	.247	.319	.402	.721
19	Phillies	1,188	1,209	.496	2,397	.504	81,490	10,462	20,304	3,958	449	2,583	9,992	7,430	872	19,374	1,460	393	90,913	32,909	6,990	577	544	522	1,643	.249	.317	.404	.721
20	Blue Jays	1,187	1,210	.495	2,397	.505	81,439	11,063	20,479	4,236	279	3,106	10,580	7,720	787	18,587	1,185	418	90,843	34,591	7,621	310	587	281	1,858	.251	.320	.425	.745
21	Giants	1,160	1,237	.484	2,397	.516	81,419	10,090	20,301	4,060	476	2,240	9,612	7,381	781	18,963	1,069	434	90,818	32,033	6,776	578	659	503	1,808	.249	.315	.393	.709
22	Astros	1,160	1,235	.484	2,395	.516	81,398	10,837	20,709	4,150	320	2,802	10,332	7,439	859	18,600	1,413	518	90,727	33,905	7,272	411	620	339	1,870	.254	.321	.417	.738
23	Brewers	1,143	1,256	.476	2,399	.524	80,789	10,638	20,035	3,913	386	2,800	10,146	7,860	967	20,306	1,820	524	90,766	33,120	7,099	615	535	455	1,764	.248	.320	.410	.730
24	Red Sox	1,139	1,260	.475	2,399	.525	83,268	11,828	21,991	4,919	357	2,789	11,258	7,878	850	19,162	1,347	412	92,901	35,991	8,065	252	653	506	1,853	.264	.332	.432	.764
25	Guardians	1,127	1,265	.471	2,392	.529	80,872	10,580	20,288	4,196	351	2,475	10,057	7,737	887	18,000	1,663	487	90,596	32,611	7,022	420	680	415	1,726	.251	.321	.403	.724