Tom Cheney has struck out the most hitters in a day, with 21 strikeouts on September 12, 1962.

	NAME	SO	DAY	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Tom Cheney T. Cheney	21	9/12/1962	1	0	1.000	1	0.56	1	0	0	16.0	10	1	1	0	4	0	0	0	62	1	11.81	2.25	5.25	0.00	33.9	6.5	0.88	.270	0.56	5.63
2	Max Scherzer M. Scherzer	20	5/11/2016	1	0	1.000	1	2.00	1	0	0	9.0	6	2	2	2	0	0	0	0	33	0	20.00	0.00		2.00	60.6	0.0	0.67	.364	2.00	6.00
3	Randy Johnson R. Johnson	20	5/8/2001	0	0		1	1.00	0	0	0	9.0	3	1	1	0	0	0	0	0	29	0	20.00	0.00		0.00	69.0	0.0	0.33	.333	1.00	3.00
4	Kerry Wood K. Wood	20	5/6/1998	1	0	1.000	1	0.00	1	1	0	9.0	1	0	0	0	0	1	0	0	29	0	20.00	0.00		0.00	69.0	0.0	0.11	.125	0.00	1.00
5	Roger Clemens R. Clemens	20	9/18/1996	1	0	1.000	1	0.00	1	1	0	9.0	5	0	0	0	0	0	0	0	32	1	20.00	0.00		0.00	62.5	0.0	0.56	.417	0.00	5.00
6	Roger Clemens R. Clemens	20	4/29/1986	1	0	1.000	1	1.00	1	0	0	9.0	3	1	1	1	0	0	0	0	30	0	20.00	0.00		1.00	66.7	0.0	0.33	.222	1.00	3.00
7	Randy Johnson R. Johnson	19	8/8/1997	1	0	1.000	1	0.00	1	1	0	9.0	5	0	0	0	3	0	0	0	35	0	19.00	3.00	6.33	0.00	54.3	8.6	0.89	.385	0.00	5.00
8	Randy Johnson R. Johnson	19	6/24/1997	0	1	.000	1	4.00	1	0	0	9.0	11	4	4	2	0	0	0	0	37	0	19.00	0.00		2.00	51.4	0.0	1.22	.563	4.00	11.00
9	David Cone D. Cone	19	10/6/1991	1	0	1.000	1	0.00	1	1	0	9.0	3	0	0	0	1	0	0	0	31	0	19.00	1.00	19.00	0.00	61.3	3.2	0.44	.273	0.00	3.00
10	Nolan Ryan N. Ryan	19	6/8/1977	0	0		1	0.00	0	0	0	10.0	6	0	1	0	5	0	0	1	41	2	17.10	4.50	3.80	0.00	46.3	12.2	1.10	.353	0.90	5.40
11	Nolan Ryan N. Ryan	19	8/20/1974	0	1	.000	1	0.82	1	0	0	11.0	4	1	1	0	5	0	0	0	41	0	15.55	4.09	3.80	0.00	46.3	12.2	0.82	.235	0.82	3.27
12	Nolan Ryan N. Ryan	19	8/12/1974	1	0	1.000	1	2.00	1	0	0	9.0	7	2	2	0	2	0	0	0	36	1	19.00	2.00	9.50	0.00	52.8	5.6	1.00	.467	2.00	7.00
13	Nolan Ryan N. Ryan	19	6/14/1974	0	0		1	2.08	0	0	0	13.0	8	3	3	1	10	0	0	0	58	0	13.15	6.92	1.90	0.69	32.8	17.2	1.38	.250	2.08	5.54
14	Tom Seaver T. Seaver	19	4/22/1970	1	0	1.000	1	1.00	1	0	0	9.0	2	1	1	1	2	0	0	0	31	0	19.00	2.00	9.50	1.00	61.3	6.5	0.44	.111	1.00	2.00
15	Steve Carlton S. Carlton	19	9/15/1969	0	1	.000	1	4.00	1	0	0	9.0	9	4	4	2	2	0	0	0	38	1	19.00	2.00	9.50	2.00	50.0	5.3	1.22	.467	4.00	9.00
16	Luis Tiant L. Tiant	19	7/3/1968	1	0	1.000	1	0.00	1	1	0	10.0	6	0	0	0	0	0	0	0	36	0	17.10	0.00		0.00	52.8	0.0	0.60	.353	0.00	5.40
17	Corey Kluber C. Kluber	18	5/13/2015	1	0	1.000	1	0.00	0	0	0	8.0	1	0	0	0	0	1	0	0	26	0	20.25	0.00		0.00	69.2	0.0	0.13	.143	0.00	1.13
18	Ben Sheets B. Sheets	18	5/16/2004	1	0	1.000	1	1.00	1	0	0	9.0	3	1	1	1	1	0	0	0	31	0	18.00	1.00	18.00	1.00	58.1	3.2	0.44	.182	1.00	3.00
19	Roger Clemens R. Clemens	18	8/25/1998	1	0	1.000	1	0.00	1	1	0	9.0	3	0	0	0	0	0	0	0	30	0	18.00	0.00		0.00	60.0	0.0	0.33	.250	0.00	3.00
20	Randy Johnson R. Johnson	18	9/27/1992	0	0		1	2.25	0	0	0	8.0	6	2	2	0	4	0	0	0	34	0	20.25	4.50	4.50	0.00	52.9	11.8	1.25	.500	2.25	6.75
21	Ramon Martinez R. Martinez	18	6/4/1990	1	0	1.000	1	0.00	1	1	0	9.0	3	0	0	0	1	0	0	0	31	0	18.00	1.00	18.00	0.00	58.1	3.2	0.44	.250	0.00	3.00
22	Bill Gullickson B. Gullickson	18	9/10/1980	1	0	1.000	1	2.00	1	0	0	9.0	4	2	2	0	2	0	0	0	33	1	18.00	2.00	9.00	0.00	54.5	6.1	0.67	.308	2.00	4.00
23	Ron Guidry R. Guidry	18	6/17/1978	1	0	1.000	1	0.00	1	1	0	9.0	4	0	0	0	2	0	0	0	33	0	18.00	2.00	9.00	0.00	54.5	6.1	0.67	.308	0.00	4.00
24	Nolan Ryan N. Ryan	18	9/10/1976	1	0	1.000	1	2.00	1	0	0	9.0	3	2	2	0	9	0	0	0	41	0	18.00	9.00	2.00	0.00	43.9	22.0	1.33	.214	2.00	3.00
25	Don Wilson D. Wilson	18	7/14/1968	1	0	1.000	1	1.00	1	0	0	9.0	5	1	1	0	2	0	0	0	33	1	18.00	2.00	9.00	0.00	54.5	6.1	0.78	.385	1.00	5.00