| NAME | SO | G | H | HR | BB | HBP | IBB | K/BB | ||
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | R. Johnson | 713 | 603 | 468 | 58 | 238 | 29 | 0 | 3.00 | |
| 2 | R. Clemens | 700 | 707 | 545 | 36 | 265 | 31 | 2 | 2.64 | |
| 3 | N. Ryan | 647 | 621 | 499 | 34 | 401 | 18 | 4 | 1.61 | |
| 4 | M. Scherzer | 571 | 474 | 394 | 62 | 153 | 21 | 1 | 3.73 | |
| 5 | J. Verlander | 555 | 555 | 465 | 76 | 207 | 15 | 2 | 2.68 | |
| 6 | G. Maddux | 520 | 740 | 794 | 52 | 200 | 26 | 16 | 2.60 | |
| 7 | CC Sabathia | 508 | 560 | 485 | 59 | 177 | 21 | 1 | 2.87 | |
| 8 | M. Mussina | 504 | 536 | 486 | 51 | 150 | 6 | 1 | 3.36 | |
| 9 | B. Colon | 481 | 552 | 535 | 58 | 171 | 15 | 2 | 2.81 | |
| 10 | F. Tanana | 478 | 612 | 616 | 59 | 209 | 24 | 22 | 2.29 | |
| 11 | C. Kershaw | 473 | 451 | 341 | 38 | 142 | 13 | 1 | 3.33 | |
| 12 | Z. Greinke | 473 | 541 | 562 | 51 | 127 | 13 | 0 | 3.72 | |
| 13 | P. Martinez | 443 | 409 | 361 | 41 | 100 | 28 | 0 | 4.43 | |
| 14 | J. Smoltz | 441 | 481 | 452 | 47 | 192 | 11 | 10 | 2.30 | |
| 15 | B. Blyleven | 439 | 544 | 533 | 41 | 174 | 17 | 6 | 2.52 | |
| 16 | A.J. Burnett | 432 | 430 | 387 | 28 | 155 | 22 | 2 | 2.79 | |
| 17 | C. Sale | 431 | 312 | 252 | 29 | 93 | 21 | 1 | 4.63 | |
| 18 | C. Morton | 428 | 410 | 377 | 34 | 175 | 46 | 1 | 2.45 | |
| 19 | C. Schilling | 424 | 436 | 408 | 51 | 109 | 8 | 3 | 3.89 | |
| 20 | A. Pettitte | 422 | 521 | 511 | 45 | 172 | 15 | 3 | 2.45 | |
| 21 | J. Lester | 415 | 451 | 442 | 52 | 192 | 16 | 0 | 2.16 | |
| 22 | D. Cone | 409 | 419 | 364 | 41 | 177 | 19 | 1 | 2.31 | |
| 23 | J. Lackey | 407 | 446 | 440 | 45 | 147 | 20 | 1 | 2.77 | |
| 24 | C. Hamels | 404 | 422 | 380 | 52 | 137 | 17 | 4 | 2.95 | |
| 25 | J. Vazquez | 402 | 443 | 435 | 59 | 121 | 13 | 1 | 3.32 | |