| NAME | SO | G | H | HR | BB | HBP | IBB | K/BB | ||
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | R. Johnson | 764 | 603 | 435 | 60 | 204 | 31 | 1 | 3.75 | |
| 2 | R. Clemens | 749 | 704 | 582 | 59 | 227 | 31 | 3 | 3.30 | |
| 3 | N. Ryan | 665 | 609 | 432 | 44 | 307 | 17 | 1 | 2.17 | |
| 4 | J. Verlander | 596 | 554 | 436 | 44 | 120 | 16 | 2 | 4.97 | |
| 5 | M. Scherzer | 572 | 470 | 373 | 48 | 103 | 17 | 4 | 5.55 | |
| 6 | CC Sabathia | 533 | 559 | 495 | 53 | 166 | 21 | 3 | 3.21 | |
| 7 | G. Maddux | 529 | 736 | 630 | 56 | 113 | 12 | 20 | 4.68 | |
| 8 | C. Kershaw | 512 | 450 | 314 | 38 | 96 | 5 | 3 | 5.33 | |
| 9 | Z. Greinke | 507 | 540 | 495 | 47 | 129 | 6 | 4 | 3.93 | |
| 10 | J. Smoltz | 504 | 481 | 398 | 39 | 149 | 3 | 3 | 3.38 | |
| 11 | P. Martinez | 496 | 407 | 301 | 42 | 108 | 20 | 5 | 4.59 | |
| 12 | M. Mussina | 470 | 534 | 537 | 55 | 137 | 9 | 1 | 3.43 | |
| 13 | F. Tanana | 466 | 602 | 508 | 53 | 169 | 20 | 8 | 2.76 | |
| 14 | C. Schilling | 452 | 436 | 379 | 38 | 73 | 4 | 0 | 6.19 | |
| 15 | T. Glavine | 452 | 678 | 598 | 50 | 188 | 4 | 18 | 2.40 | |
| 16 | J. Vazquez | 450 | 443 | 412 | 55 | 131 | 15 | 9 | 3.44 | |
| 17 | J. Lester | 441 | 450 | 436 | 56 | 146 | 13 | 3 | 3.02 | |
| 18 | J. Moyer | 435 | 641 | 588 | 78 | 168 | 22 | 4 | 2.59 | |
| 19 | A.J. Burnett | 430 | 430 | 371 | 48 | 182 | 19 | 4 | 2.36 | |
| 20 | C. Morton | 424 | 405 | 328 | 39 | 158 | 27 | 5 | 2.68 | |
| 21 | C. Hamels | 423 | 419 | 336 | 47 | 104 | 20 | 5 | 4.07 | |
| 22 | D. Cone | 418 | 420 | 335 | 41 | 156 | 20 | 5 | 2.68 | |
| 23 | B. Colon | 415 | 546 | 546 | 68 | 157 | 5 | 5 | 2.64 | |
| 24 | B. Blyleven | 415 | 543 | 469 | 38 | 145 | 20 | 2 | 2.86 | |
| 25 | F. Hernandez | 411 | 416 | 356 | 36 | 117 | 11 | 1 | 3.51 | |