Between September 24, 2025 and October 6, 2025, the Chicago Cubs have the highest run differential by a team, with a differential of 21 runs.
| TEAM | DIFF | G | W% | W | L | AB | R | H | 2B | 3B | HR | RBI | BB | HBP | SO | SB | CS | PA | TB | XBH | SH | SF | IBB | GIDP | AVG | OBP | SLG | OPS | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Cubs | 21 | 5 | .800 | 4 | 1 | 165 | 36 | 46 | 8 | 2 | 14 | 34 | 13 | 1 | 44 | 3 | 0 | 180 | 100 | 24 | 0 | 1 | 1 | 3 | .279 | .333 | .606 | .939 |
| 2 |  | Yankees | 19 | 5 | 1.000 | 5 | 0 | 156 | 30 | 40 | 5 | 1 | 11 | 30 | 23 | 2 | 43 | 1 | 2 | 182 | 80 | 17 | 0 | 1 | 2 | 1 | .256 | .357 | .513 | .870 |
| 3 |  | Dodgers | 17 | 5 | 1.000 | 5 | 0 | 181 | 27 | 43 | 8 | 1 | 10 | 26 | 13 | 1 | 53 | 2 | 1 | 196 | 83 | 19 | 0 | 1 | 0 | 2 | .238 | .291 | .459 | .749 |
| 4 |  | Blue Jays | 14 | 5 | .800 | 4 | 1 | 157 | 29 | 40 | 9 | 2 | 9 | 29 | 15 | 2 | 39 | 3 | 1 | 176 | 80 | 20 | 1 | 1 | 0 | 4 | .255 | .326 | .510 | .835 |
| 5 |  | Padres | 13 | 4 | .750 | 3 | 1 | 133 | 25 | 36 | 6 | 0 | 6 | 25 | 14 | 1 | 37 | 1 | 1 | 150 | 60 | 12 | 1 | 1 | 1 | 0 | .271 | .342 | .451 | .793 |
| 6 |  | Royals | 12 | 5 | .600 | 3 | 2 | 173 | 27 | 40 | 9 | 0 | 6 | 25 | 17 | 2 | 40 | 4 | 1 | 193 | 67 | 15 | 0 | 1 | 1 | 1 | .231 | .306 | .387 | .693 |
| 7 |  | Giants | 9 | 4 | 1.000 | 4 | 0 | 123 | 18 | 29 | 6 | 2 | 6 | 17 | 16 | 2 | 26 | 0 | 2 | 143 | 57 | 14 | 0 | 2 | 1 | 0 | .236 | .329 | .463 | .792 |
| 8 |  | Phillies | 9 | 5 | .800 | 4 | 1 | 162 | 17 | 36 | 3 | 0 | 10 | 17 | 9 | 0 | 57 | 2 | 0 | 174 | 69 | 13 | 1 | 2 | 0 | 2 | .222 | .260 | .426 | .686 |
| 9 |  | Astros | 8 | 5 | .600 | 3 | 2 | 175 | 26 | 41 | 10 | 0 | 10 | 25 | 14 | 3 | 47 | 7 | 2 | 192 | 81 | 20 | 0 | 0 | 0 | 2 | .234 | .302 | .463 | .765 |
| 10 |  | Pirates | 5 | 5 | .600 | 3 | 2 | 174 | 18 | 41 | 9 | 0 | 4 | 17 | 15 | 2 | 51 | 3 | 2 | 191 | 62 | 13 | 0 | 0 | 0 | 4 | .236 | .304 | .356 | .660 |
| 11 |  | Twins | 4 | 5 | .400 | 2 | 3 | 165 | 13 | 35 | 6 | 1 | 7 | 13 | 8 | 0 | 58 | 3 | 3 | 174 | 64 | 14 | 1 | 0 | 0 | 3 | .212 | .249 | .388 | .636 |
| 12 |  | Reds | 3 | 5 | .600 | 3 | 2 | 176 | 17 | 44 | 7 | 0 | 5 | 16 | 15 | 2 | 52 | 1 | 0 | 195 | 66 | 12 | 0 | 2 | 0 | 4 | .250 | .313 | .375 | .688 |
| 13 |  | Mariners | 3 | 5 | .400 | 2 | 3 | 171 | 21 | 45 | 8 | 0 | 7 | 20 | 15 | 4 | 55 | 8 | 0 | 192 | 74 | 15 | 1 | 1 | 3 | 0 | .263 | .335 | .433 | .768 |
| 14 |  | Red Sox | 2 | 5 | .600 | 3 | 2 | 164 | 17 | 40 | 10 | 1 | 4 | 17 | 11 | 1 | 46 | 2 | 0 | 177 | 64 | 15 | 0 | 1 | 0 | 5 | .244 | .294 | .390 | .684 |
| 15 |  | Guardians | 0 | 5 | .600 | 3 | 2 | 162 | 22 | 35 | 10 | 1 | 5 | 22 | 13 | 2 | 45 | 7 | 1 | 180 | 62 | 16 | 1 | 2 | 1 | 0 | .216 | .279 | .383 | .662 |
| 16 |  | Rangers | 0 | 5 | .400 | 2 | 3 | 167 | 21 | 33 | 8 | 0 | 4 | 19 | 8 | 3 | 50 | 2 | 2 | 179 | 53 | 12 | 1 | 0 | 1 | 1 | .198 | .247 | .317 | .565 |
| 17 |  | White Sox | -1 | 5 | .400 | 2 | 3 | 172 | 27 | 42 | 8 | 0 | 8 | 27 | 10 | 2 | 46 | 3 | 0 | 188 | 74 | 16 | 1 | 3 | 0 | 1 | .244 | .289 | .430 | .719 |
| 18 |  | Brewers | -1 | 4 | .500 | 2 | 2 | 129 | 12 | 27 | 9 | 0 | 3 | 12 | 15 | 4 | 37 | 4 | 1 | 149 | 45 | 12 | 1 | 0 | 0 | 4 | .209 | .311 | .349 | .660 |
| 19 |  | Tigers | -3 | 5 | .400 | 2 | 3 | 167 | 13 | 39 | 3 | 0 | 4 | 13 | 18 | 1 | 51 | 1 | 1 | 187 | 54 | 7 | 0 | 1 | 0 | 5 | .234 | .310 | .323 | .634 |
| 20 |  | Braves | -6 | 4 | .250 | 1 | 3 | 127 | 11 | 25 | 5 | 1 | 6 | 10 | 16 | 0 | 39 | 2 | 1 | 143 | 50 | 12 | 0 | 0 | 0 | 2 | .197 | .287 | .394 | .680 |
| 21 |  | Mets | -7 | 5 | .400 | 2 | 3 | 164 | 18 | 33 | 6 | 0 | 6 | 17 | 19 | 1 | 44 | 5 | 0 | 185 | 57 | 12 | 1 | 0 | 0 | 2 | .201 | .288 | .348 | .636 |
| 22 |  | Nationals | -7 | 4 | .500 | 2 | 2 | 134 | 19 | 32 | 3 | 0 | 12 | 19 | 5 | 0 | 45 | 2 | 0 | 139 | 71 | 15 | 0 | 0 | 0 | 5 | .239 | .266 | .530 | .796 |
| 23 |  | Athletics | -8 | 5 | .400 | 2 | 3 | 169 | 19 | 41 | 11 | 0 | 5 | 19 | 16 | 1 | 49 | 1 | 0 | 186 | 67 | 16 | 0 | 0 | 0 | 3 | .243 | .312 | .396 | .708 |
| 24 |  | Marlins | -8 | 5 | .400 | 2 | 3 | 153 | 11 | 30 | 4 | 2 | 1 | 11 | 12 | 5 | 33 | 6 | 3 | 170 | 41 | 7 | 0 | 0 | 0 | 2 | .196 | .276 | .268 | .544 |
| 25 |  | Angels | -12 | 5 | .400 | 2 | 3 | 157 | 14 | 30 | 5 | 0 | 7 | 13 | 13 | 0 | 43 | 2 | 1 | 170 | 56 | 12 | 0 | 0 | 0 | 4 | .191 | .253 | .357 | .610 |
Some of the information used here was obtained free of charge from Retrosheet.
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