Stan Hack has gotten the most career hits for the Cubs versus the Reds, with 352 hits.

	NAME	H	G	AB	R	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Stan Hack S. Hack	352	272	1,014	180	61	16	4	87	177	2	68	19		1,207	457	81	14			7	.347	.445	.451	.896
2	Ernie Banks E. Banks	312	311	1,186	155	62	8	61	203	82	7	137	6	7	1,302	573	131	7	20	14	28	.263	.310	.483	.793
3	Phil Cavarretta P. Cavarretta	275	287	957	138	50	20	10	131	114	6	75	9	0	1,091	395	80	14			7	.287	.367	.413	.780
4	Gabby Hartnett G. Hartnett	256	276	871	109	61	11	26	149	86	5	76	2		987	417	98	25			2	.294	.361	.479	.839
5	Billy Williams B. Williams	247	215	808	147	39	4	53	151	104	6	67	8	1	927	453	96	1	8	20	15	.306	.386	.561	.946
6	Billy Herman B. Herman	244	198	812	120	58	15	2	90	54	7	44	6		896	338	75	23			5	.300	.349	.416	.766
7	Ron Santo R. Santo	242	220	836	122	37	8	43	159	101	6	125	7	7	953	424	88	2	8	14	22	.289	.367	.507	.874
8	Frank Schulte F. Schulte	225	240	867	109	28	23	6		77	10		23		1,006	317	57	52				.260	.327	.366	.693
9	Joe Tinker J. Tinker	216	220	785	94	27	13	3		48	1		35		872	278	43	38				.275	.318	.354	.672
10	Johnny Evers J. Evers	195	205	690	128	31	13	1		89	5		39		812	255	45	28				.283	.369	.370	.738
11	Ryne Sandberg R. Sandberg	194	165	655	93	37	6	16	78	61	3	110	24	9	723	291	59	0	4	5	10	.296	.357	.444	.801
12	Charlie Grimm C. Grimm	186	188	700	77	30	9	6	94	42	2	35	3		764	252	45	20				.266	.309	.360	.669
13	Sammy Sosa S. Sosa	181	162	643	109	25	0	50	115	71	2	160	14	5	720	356	75	0	4	17	23	.281	.353	.554	.906
14	Don Kessinger D. Kessinger	177	149	599	78	28	8	3	63	45	0	56	5	6	657	230	39	8	5	6	14	.295	.342	.384	.726
15	Mark Grace M. Grace	176	148	565	82	39	4	13	78	61	3	46	5	3	643	262	56	2	12	4	11	.312	.374	.464	.838
16	Bill Nicholson B. Nicholson	169	198	703	98	26	8	26	113	105	4	88	4		814	289	60	2			11	.240	.342	.411	.753
17	Riggs Stephenson R. Stephenson	169	126	447	72	31	12	2	76	49	4	16	8		509	230	45	9				.378	.444	.515	.959
18	Frank Chance F. Chance	163	159	515	99	24	12	2		86	28		54		649	217	38	20				.317	.440	.421	.862
19	Heinie Zimmerman H. Zimmerman	162	149	532	72	25	19	4		24	3	43	13		579	237	48	20				.305	.338	.445	.784
20	Kiki Cuyler K. Cuyler	161	134	508	77	29	9	5	78	53	4	35	24		589	223	43	24				.317	.386	.439	.825
21	Jimmy Sheckard J. Sheckard	159	142	495	94	18	15	5		95	6		22		615	222	38	19				.321	.436	.448	.885
22	Andy Pafko A. Pafko	155	130	501	77	33	8	17	89	41	1	40	3	0	549	255	58	6			14	.309	.363	.509	.872
23	Anthony Rizzo A. Rizzo	147	153	568	102	35	0	34	95	81	24	112	6	3	676	284	69	0	3	11	15	.259	.373	.500	.873
24	Glenn Beckert G. Beckert	147	118	491	72	24	1	2	38	26	1	23	2	3	530	179	27	8	4	1	9	.299	.333	.365	.698
25	Woody English W. English	147	148	586	91	21	11	2	40	62	2	61	5		667	196	34	17				.251	.325	.334	.659