which mlb team had the best run differential head to head in a season 2001

The St. Louis Cardinals had the highest run differential by a team against a team in 2001, with a differential of 74 runs against the Pirates.

	TEAM	DIFF	OPP	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Cardinals	74	Pirates	2001	17	.824	14	3	563	111	157	34	6	19	100	63	9	100	10	2	653	260	59	11	7	11	17	.279	.357	.462	.819
2	Twins	52	Tigers	2001	19	.789	15	4	668	121	204	45	7	23	114	58	6	100	13	9	743	332	75	4	7	6	11	.305	.363	.497	.860
3	Indians	44	Twins	2001	19	.737	14	5	678	117	199	40	7	30	114	71	8	132	4	2	771	343	77	7	7	5	8	.294	.364	.506	.870
4	Mariners	43	Rangers	2001	20	.750	15	5	711	140	211	53	8	32	139	81	11	109	22	8	813	376	93	2	8	5	11	.297	.374	.529	.902
5	Mariners	41	Angels	2001	19	.789	15	4	640	92	178	33	5	13	88	69	5	105	21	5	725	260	51	5	6	4	12	.278	.350	.406	.756
6	Yankees	39	Devil Rays	2001	19	.684	13	6	616	99	153	34	1	28	98	65	7	118	10	9	699	273	63	3	8	2	11	.248	.323	.443	.766
7	Cubs	38	Reds	2001	17	.765	13	4	587	94	162	33	2	19	89	57	9	103	6	5	671	256	54	15	3	6	9	.276	.348	.436	.784
8	Red Sox	38	Devil Rays	2001	19	.737	14	5	656	123	192	44	2	29	118	82	11	122	5	2	760	327	75	3	8	3	16	.293	.376	.498	.875
9	Athletics	35	Devil Rays	2001	9	.778	7	2	326	67	94	19	1	18	62	48	3	58	5	2	379	169	38	0	2	2	3	.288	.383	.518	.901
10	White Sox	33	Tigers	2001	19	.684	13	6	670	102	196	33	8	20	97	66	6	102	14	7	760	305	61	10	8	8	16	.293	.357	.455	.813
11	Giants	33	Padres	2001	19	.737	14	5	680	110	198	35	3	36	106	81	5	145	8	6	785	347	74	12	7	9	7	.291	.367	.510	.878
12	Diamondbacks	32	Padres	2001	19	.632	12	7	666	93	177	37	5	24	87	64	5	116	9	5	745	296	66	7	3	13	13	.266	.333	.444	.778
13	Dodgers	32	Giants	2001	19	.579	11	8	655	112	187	40	6	24	103	58	4	113	8	3	737	311	70	11	9	6	8	.285	.343	.475	.818
14	Athletics	32	Angels	2001	20	.700	14	6	671	87	163	43	1	16	79	76	9	126	7	4	763	256	60	2	5	9	14	.243	.326	.382	.707
15	Rockies	31	Cardinals	2001	9	.667	6	3	292	64	93	13	4	19	62	35	3	42	2	1	345	171	36	9	6	5	7	.318	.390	.586	.975
16	Mariners	30	Twins	2001	9	.889	8	1	318	61	100	16	4	9	60	22	5	52	8	3	357	151	29	2	10	0	3	.314	.358	.475	.833
17	Astros	30	Reds	2001	17	.647	11	6	580	96	164	39	1	22	91	74	2	100	4	7	673	271	62	8	9	6	13	.283	.361	.467	.828
18	Diamondbacks	30	Rockies	2001	19	.684	13	6	655	123	180	38	4	26	115	76	14	121	9	5	763	304	68	12	6	12	13	.275	.360	.464	.824
19	Mariners	29	Orioles	2001	9	.889	8	1	297	46	84	16	0	12	46	34	2	48	19	3	338	136	28	0	5	3	5	.283	.355	.458	.813
20	Indians	28	Royals	2001	19	.579	11	8	642	114	182	23	4	32	109	87	7	102	9	7	743	309	59	3	4	2	33	.283	.373	.481	.854
21	Tigers	28	Rangers	2001	9	.889	8	1	332	66	106	22	5	12	60	33	3	41	6	5	371	174	39	1	2	3	5	.319	.384	.524	.908
22	Marlins	27	Expos	2001	19	.632	12	7	636	91	172	45	4	16	87	67	6	128	16	3	719	273	65	6	4	2	15	.270	.344	.429	.773
23	Astros	27	Brewers	2001	17	.706	12	5	577	86	155	31	5	22	84	72	8	112	8	7	669	262	58	8	4	10	12	.269	.356	.454	.810
24	Diamondbacks	27	Dodgers	2001	19	.526	10	9	681	100	175	29	5	29	95	57	3	138	3	3	752	301	63	10	1	4	11	.257	.317	.442	.759
25	Yankees	27	Royals	2001	6	1.000	6	0	214	46	70	9	2	10	44	24	0	32	7	2	239	113	21	1	0	1	5	.327	.395	.528	.923

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More Cardinals Stats

Team Batting Leaders

28

Walker

RBI

109

Burleson

AVG

.283

Burleson

Team Pitching Leaders

12

Pallante

146

Liberatore

ERA

2.61

Graceffo

Team Rankings

157

22nd

683

9th

1,188

24th

ERA

4.29

21st

2026 Division Standings

TEAM	W	L	PCT	GB
Brewers	93	57	.620
Cubs	83	67	.553	10.0
Pirates	75	75	.500	18.0
Cardinals	74	76	.493	19.0
Reds	70	79	.470	22.5

Schedule

DATE	MATCHUP			TIME (ET)
Mon 9/14	SFG	@	STL	7:45 PM
Tue 9/15	SFG	@	STL	7:45 PM
Wed 9/16	SFG	@	STL	1:15 PM
Fri 9/18	WSH	@	STL	8:15 PM
Sat 9/19	WSH	@	STL	7:15 PM

Last Game

White Sox

76 - 73

Final

Cardinals

74 - 76

Sun 13 Sep 2026

MLB 2026 Batting Leaders

HR Leaders

44

Schwarber

41

Crow-Armstrong

40

Caminero

RBI Leaders

109

Burleson

107

Stewart

100

Walker

Batting Average Leaders

.313

Arraez

.310

Alvarez

.309

Lopez

Hit Leaders

180

Lopez

177

Arraez

173

Díaz

Run Leaders

111

Crow-Armstrong

102

Wood

101

Reynolds

OBP Leaders

.427

Alvarez

.395

Wood

.394

Bauers

SLG Leaders

.589

Alvarez

.562

Crow-Armstrong

.551

García

SB Leaders

46

Nuñez

41

Simpson

40

Chisholm

MLB 2026 Pitching Leaders

Win Leaders

17

Sánchez

17

Gray

15

Burns

Strikeout Leaders

236

Misiorowski

236

Cease

228

Schlittler

ERA Leaders

1.95

Schlittler

1.95

Misiorowski

2.18

Sale

WHIP Leaders

0.80

Misiorowski

0.88

Yamamoto

0.90

Schlittler

K/9 Leaders

13.17

Misiorowski

12.77

Cease

12.14

Williams

K/BB Leaders

6.13

Sale

5.93

Rasmussen

5.76

Misiorowski

Walk Leaders

24

Martinez

27

Rasmussen

31

Sale

MLB Fantasy 2026

FanDuel Points Leaders

2,264.8

Ohtani

2,156.2

Crow-Armstrong

1,903

Alvarez

DraftKings Points Leaders

1,634

Crow-Armstrong

1,592.6

Ohtani

1,426

Alvarez

MLB 2026 Betting

Best Record ATS

84-65

84-66

84-67

80-69

Worst Record ATS

57-93

60-89

64-86

68-82

70-80

70-79

MLB 2026 Standings

NL East	W	L	PCT	GB
Braves	88	62	.587
Phillies	83	67	.553	5.0
Marlins	74	76	.493	14.0
Nationals	70	81	.464	18.5
Mets	69	80	.463	18.5
NL Central	W	L	PCT	GB
Brewers - x	93	57	.620
Cubs	83	67	.553	10.0
Pirates	75	75	.500	18.0
Cardinals	74	76	.493	19.0
Reds	70	79	.470	22.5
NL West	W	L	PCT	GB
Dodgers	90	59	.604
Padres	81	68	.544	9.0
Diamondbacks	79	71	.527	11.5
Giants	62	88	.413	28.5
Rockies	55	94	.369	35.0

AL East	W	L	PCT	GB
Rays - x	90	59	.604
Yankees	86	63	.577	4.0
Red Sox	82	68	.547	8.5
Blue Jays	75	75	.500	15.5
Orioles	72	78	.480	18.5
AL Central	W	L	PCT	GB
White Sox	76	73	.510
Guardians	76	74	.507	0.5
Twins	70	79	.470	6.0
Tigers	70	79	.470	6.0
Royals	66	84	.440	10.5
AL West	W	L	PCT	GB
Astros	75	75	.500
Rangers	74	76	.493	1.0
Mariners	70	80	.467	5.0
Athletics	61	89	.407	14.0
Angels	56	93	.376	18.5

MLB 2026 Scores & Schedule

Scores

DATE	MATCHUP			SCORE
Sun 8/30	COL	@	ATL	2-3
Sun 8/30	BOS	@	NYY	1-16
Sun 8/30	SEA	@	TOR	0-7
Sun 8/30	LAD	@	DET	6-1
Sun 8/30	SDP	@	TBR	4-5

Schedule

DATE	MATCHUP			TIME (ET)
Mon 9/14	CWS	@	CLE	6:40 PM
Mon 9/14	LAD	@	CIN	6:40 PM
Mon 9/14	DET	@	TOR	7:07 PM
Mon 9/14	BAL	@	NYM	7:10 PM
Mon 9/14	NYY	@	MIN	7:40 PM

The St. Louis Cardinals had the highest run differential by a team against a team in 2001, with a differential of 74 runs against the Pirates.

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28

109

.283

12

146

2.61

MLB 2026 Batting Leaders

44

41

40

109

107

100

.313

.310

.309

180

177

173

111

102

101

.427

.395

.394

.589

.562

.551

46

41

40

MLB 2026 Pitching Leaders

17

17

15

236

236

228

1.95

1.95

2.18

0.80

0.88

0.90

13.17

12.77

12.14

6.13

5.93

5.76

24

27

31

MLB Fantasy 2026

2,264.8

2,156.2

1,903

1,634

1,592.6

1,426

MLB 2026 Betting

MLB 2026 Standings

MLB 2026 Scores & Schedule

Scores

Schedule