which pitcher has the most strikeouts against the houston astros

Sandy Koufax has struck out the most batters in a season versus the Houston Colt .45's, with 53 strikeouts in 1963.

Showing:

Regular season

	NAME	SO	SEASON	TM	G	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Sandy Koufax S. Koufax	53	1963	LAD	6	5	1	.833	6	1.43	5	3	0	50.1	29	8	9	1	8	1	0	0	191	0	9.48	1.43	6.63	0.18	27.7	4.2	0.74	.219	1.61	5.19
2	Yu Darvish Y. Darvish	52	2013	TEX	5	3	1	.750	5	2.83	0	0	0	35.0	15	11	11	5	12	0	0	0	132	0	13.37	3.09	4.33	1.29	39.4	9.1	0.77	.159	2.83	3.86
3	Sandy Koufax S. Koufax	51	1965	LAD	5	4	0	1.000	5	1.62	3	1	0	44.1	20	8	8	2	9	2	0	0	163	1	10.35	1.83	5.67	0.41	31.3	5.5	0.65	.182	1.62	4.06
4	Chris Short C. Short	47	1965	PHI	6	4	1	.800	6	2.20	2	2	0	45.0	32	11	14	2	13	0	0	0	179	0	9.40	2.60	3.62	0.40	26.3	7.3	1.00	.256	2.80	6.40
5	Bob Gibson B. Gibson	46	1963	STL	5	4	0	1.000	4	2.13	4	0	0	42.1	34	10	11	1	10	0	0	0	169	0	9.78	2.13	4.60	0.21	27.2	5.9	1.04	.295	2.34	7.23
6	Shohei Ohtani S. Ohtani	45	2022	LAA	5	3	1	.750	5	1.21	0	0	0	29.2	21	4	4	0	6	0	0	0	114	1	13.65	1.82	7.50	0.00	39.5	5.3	0.91	.333	1.21	6.37
7	Fernando Valenzuela F. Valenzuela	41	1986	LAD	6	3	3	.500	6	2.63	4	0	0	48.0	38	14	18	2	15	0	0	1	194	3	7.69	2.81	2.73	0.38	21.1	7.7	1.10	.265	3.38	7.13
8	Clay Kirby C. Kirby	41	1971	SDP	5	1	2	.333	5	1.93	1	0	0	46.2	31	10	11	3	20	0	0	1	191	4	7.91	3.86	2.05	0.58	21.5	10.5	1.09	.220	2.12	5.98
9	Bob Gibson B. Gibson	41	1968	STL	5	4	1	.800	5	0.57	4	2	0	47.0	30	3	5	0	9	1	0	2	177	0	7.85	1.72	4.56	0.00	23.2	5.1	0.83	.238	0.96	5.74
10	Jim Maloney J. Maloney	41	1966	CIN	6	2	1	.667	6	1.87	3	0	0	43.1	31	9	10	1	15	0	0	0	172	0	8.52	3.12	2.73	0.21	23.8	8.7	1.06	.261	2.08	6.44
11	Mark Prior M. Prior	40	2002	CHC	5	1	2	.333	5	4.45	0	0	0	28.1	29	14	16	6	10	2	0	0	127	0	12.71	3.18	4.00	1.91	31.5	7.9	1.38	.333	5.08	9.21
12	Lance Lynn L. Lynn	39	2019	TEX	4	1	3	.250	4	3.54	0	0	0	28.0	26	11	11	8	6	0	0	0	115	0	12.54	1.93	6.50	2.57	33.9	5.2	1.14	.290	3.54	8.36
13	Tom Seaver T. Seaver	39	1968	NYM	5	2	1	.667	5	1.44	1	1	0	43.2	24	7	8	1	7	2	0	0	162	1	8.04	1.44	5.57	0.21	24.1	4.3	0.71	.204	1.65	4.95
14	Bob Gibson B. Gibson	38	1962	STL	6	3	3	.500	6	2.40	4	0	0	48.2	36	13	16	5	22	0	0	4	201	3	7.03	4.07	1.73	0.92	18.9	10.9	1.19	.228	2.96	6.66
15	John Smoltz J. Smoltz	37	1992	ATL	5	2	1	.667	5	2.08	0	0	0	34.2	31	8	9	2	9	1	0	0	146	2	9.61	2.34	4.11	0.52	25.3	6.2	1.15	.299	2.34	8.05
16	Mario Soto M. Soto	37	1984	CIN	5	3	1	.750	5	2.36	2	0	0	42.0	23	11	13	2	17	0	0	1	163	1	7.93	3.64	2.18	0.43	22.7	10.4	0.95	.196	2.79	4.93
17	Don Sutton D. Sutton	37	1972	LAD	5	2	1	.667	5	0.90	2	2	0	40.0	22	4	8	1	16	0	0	0	155	2	8.33	3.60	2.31	0.23	23.9	10.3	0.95	.208	1.80	4.95
18	Claude Osteen C. Osteen	37	1969	LAD	6	6	0	1.000	6	1.50	6	1	0	54.0	33	9	9	1	9	4	0	0	199	1	6.17	1.50	4.11	0.17	18.6	4.5	0.78	.216	1.50	5.50
19	Steve Carlton S. Carlton	36	1967	STL	5	3	1	.750	4	2.91	2	0	1	34.0	23	11	11	1	15	0	1	0	140	3	9.53	3.97	2.40	0.26	25.7	10.7	1.12	.250	2.91	6.09
20	Tony Cloninger T. Cloninger	36	1965	MIL	6	4	1	.800	6	3.80	3	0	0	45.0	36	19	20	5	21	1	0	0	184	4	7.20	4.20	1.71	1.00	19.6	11.4	1.27	.256	4.00	7.20
21	Ray Sadecki R. Sadecki	35	1968	SFG	5	2	1	.667	5	2.08	1	1	0	34.2	23	8	9	1	12	0	0	4	136	2	9.09	3.12	2.92	0.26	25.7	8.8	1.01	.250	2.34	5.97
22	Gerry Arrigo G. Arrigo	35	1968	CIN	6	0	5	.000	6	3.35	0	0	0	37.2	31	14	17	2	18	2	0	5	159	2	8.36	4.30	1.94	0.48	22.0	11.3	1.30	.284	4.06	7.41
23	C.J. Wilson	34	2013	LAA	4	2	2	.500	4	2.03	0	0	0	26.2	21	6	12	4	9	1	0	1	111	1	11.48	3.04	3.78	1.35	30.6	8.1	1.13	.270	4.05	7.09
24	Hisashi Iwakuma H. Iwakuma	33	2013	SEA	4	2	1	.667	4	1.38	0	0	0	26.0	23	4	6	1	7	1	0	1	108	2	11.42	2.42	4.71	0.35	30.6	6.5	1.15	.333	2.08	7.96
25	Phil Niekro P. Niekro	33	1979	ATL	5	3	2	.600	5	3.54	4	0	0	40.2	32	16	19	2	16	1	0	0	167	7	7.30	3.54	2.06	0.44	19.8	9.6	1.18	.261	4.20	7.08

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StatMuse has game-level data for strikeouts going back to the 1901 season.

Some of the information used here was obtained free of charge from Retrosheet.

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Dodgers	95	60	.613
Padres	86	69	.555	9.0
Diamondbacks	81	74	.523	14.0
Giants	64	91	.413	31.0
Rockies	57	98	.368	38.0

Schedule

DATE	MATCHUP			TIME (ET)
Sun 9/20	SFG	@	LAD	4:10 PM
Tue 9/22	SDP	@	LAD	10:10 PM
Wed 9/23	SDP	@	LAD	10:10 PM
Thu 9/24	SDP	@	LAD	10:10 PM
Fri 9/25	LAD	@	SFG	10:15 PM

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Nationals	73	82	.471	18.0
Mets	71	84	.458	20.0
NL Central	W	L	PCT	GB
Brewers - y	97	58	.626
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Sat 9/5	SFG	@	NYM	9-5
Sat 9/5	CHC	@	MIA	6-5
Sat 9/5	ATL	@	PHI	2-4
Sat 9/5	DET	@	CLE	6-0
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DATE	MATCHUP			TIME (ET)
Sun 9/20	PHI	@	NYM	1:10 PM
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Sandy Koufax has struck out the most batters in a season versus the Houston Colt .45's, with 53 strikeouts in 1963.

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