which team had the highest margin of victory in a single playoff series

The New York Yankees have the highest run differential by a team in the postseason when hitting >0 singles, with a differential of 303 runs.

	TEAM	DIFF	1B	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	303	2,507	437	.578	252	184	14,788	1,944	3,668	608	76	477	1,843	1,595	129	2,910	192	105	16,737	5,859	1,161	143	82	144	297	.248	.325	.396	.721
2	Red Sox	90	1,149	200	.543	108	91	6,876	910	1,732	330	58	195	853	694	61	1,347	81	43	7,756	2,763	583	79	46	72	153	.252	.324	.402	.726
3	Orioles	75	549	103	.524	54	49	3,481	408	801	141	7	104	384	332	24	694	29	23	3,883	1,268	252	21	25	34	74	.230	.300	.364	.664
4	Mets	53	602	105	.562	59	46	3,612	452	854	139	13	100	425	372	41	787	69	19	4,100	1,319	252	43	32	46	65	.236	.312	.365	.677
5	Royals	39	487	80	.538	43	37	2,701	334	684	116	22	59	320	236	20	525	67	37	3,012	1,021	197	25	30	23	50	.253	.315	.378	.693
6	Phillies	35	692	137	.504	69	68	4,498	558	1,072	208	25	147	529	471	47	987	91	37	5,098	1,771	380	54	28	63	91	.238	.315	.394	.709
7	Astros	24	882	161	.516	83	78	5,490	677	1,319	219	13	205	653	568	73	1,244	83	29	6,208	2,179	437	47	30	65	128	.240	.318	.397	.715
8	Diamondbacks	10	325	57	.491	28	29	1,920	235	476	76	10	65	231	183	21	482	40	13	2,160	767	151	25	11	21	43	.248	.319	.399	.718
9	Cardinals	8	1,464	262	.511	134	128	8,675	1,030	2,103	395	53	191	958	743	74	1,705	143	65	9,692	3,177	639	153	47	106	147	.242	.306	.366	.672
10	Braves	8	1,190	211	.483	102	109	7,122	829	1,703	280	32	201	795	735	49	1,616	132	57	8,038	2,650	513	86	46	78	128	.239	.313	.372	.685
11	Nationals	6	238	46	.522	24	22	1,540	173	349	64	4	43	164	162	12	404	26	8	1,743	550	111	18	11	19	22	.227	.303	.357	.660
12	Athletics	1	887	167	.509	85	82	5,529	599	1,292	249	26	130	556	520	41	1,116	110	52	6,201	1,983	405	86	25	48	92	.234	.303	.359	.662
13	Reds	-2	534	97	.505	49	48	3,239	346	766	140	27	65	330	274	22	574	86	40	3,601	1,155	232	41	25	46	61	.236	.298	.357	.655
14	Rangers	-3	367	69	.493	34	35	2,365	301	565	108	6	84	286	220	19	518	39	17	2,632	937	198	16	12	22	52	.239	.307	.396	.704
15	Giants	-8	1,160	195	.518	100	93	6,524	727	1,582	246	44	132	674	565	41	1,249	90	82	7,267	2,312	422	106	31	70	105	.242	.306	.354	.660
16	Blue Jays	-9	404	67	.463	31	36	2,294	284	585	109	12	60	271	209	19	446	60	15	2,555	898	181	11	22	19	51	.255	.320	.391	.711
17	Rays	-16	294	64	.438	28	36	2,135	253	476	79	8	95	248	184	18	641	39	14	2,349	856	182	5	7	9	43	.223	.289	.401	.690
18	Dodgers	-18	1,549	292	.479	140	152	9,681	1,137	2,278	382	55	292	1,088	1,006	81	2,116	181	71	10,924	3,646	729	110	46	104	184	.235	.311	.377	.688
19	Marlins	-20	226	40	.600	24	16	1,361	163	325	63	5	31	156	147	17	298	18	8	1,549	491	99	18	6	22	31	.239	.319	.361	.680
20	White Sox	-20	364	62	.484	30	32	2,061	228	508	90	12	42	211	187	34	385	47	34	2,327	748	144	36	9	10	40	.246	.318	.363	.681
21	Rockies	-27	136	24	.417	10	14	829	90	199	38	5	20	87	70	7	202	9	4	924	307	63	11	7	8	14	.240	.302	.370	.673
22	Tigers	-33	707	127	.484	61	65	4,252	462	1,005	181	16	101	434	417	41	828	65	38	4,779	1,521	298	56	13	38	93	.236	.310	.358	.667
23	Guardians	-35	669	128	.500	64	64	4,314	507	995	183	16	127	477	427	48	1,011	90	26	4,856	1,591	326	42	25	38	84	.231	.305	.369	.674
24	Mariners	-39	211	39	.436	17	22	1,355	151	318	59	4	44	144	133	12	332	26	11	1,521	517	107	14	7	13	22	.235	.307	.382	.689
25	Padres	-40	334	59	.407	24	35	1,958	223	473	72	8	59	209	174	19	461	22	14	2,183	738	139	13	19	11	38	.242	.307	.377	.684