The St. Louis Cardinals had the best OPS by a team against left-handed pitchers in 2022, with an OPS of .809.

which teams leads the league in ops against lefties this season
2022Cardinals2022Astros2022Braves2022Phillies2022Rockies2022Yankees2022White Sox2022Red Sox2022Dodgers2022Blue Jays2022Rangers2022Royals2022Giants2022Mets2022Reds2022Mariners2022Rays2022Padres2022Cubs2022Tigers2022Twins2022Nationals.809.782.781.771.770.769.767.759.754.754.746.722.722.717.713.711.710.704.702.701.701.680
TEAMSEASONGOPSW%WLPAABH2B3BHRRBIBBIBBHBPSOSHSFTBXBHAVGOBPSLG
St. Louis CardinalsSt. Louis Cardinals2022111.809.6849324311,3631,2013167075318313251927119559130.263.343.465
Houston AstrosHouston Astros2022128.782.7451,3784711,8491,65543198272237162113321412749172.260.329.453
Atlanta BravesAtlanta Braves2022106.781.7021,1504891,6391,4653889165319115331238318650150.265.338.444
Philadelphia PhilliesPhiladelphia Phillies2022129.771.5771,0107391,7491,555414921149199156318398415675152.266.337.434
Colorado RockiesColorado Rockies2022122.770.4809431,0211,9641,7934911071753255136518397215791177.274.329.441
New York YankeesNew York Yankees2022113.769.6821,0574931,5501,35132858367205163111735079593128.243.330.439
Chicago White SoxChicago White Sox2022104.767.5116866571,3431,2123296824015811341027126521110.271.337.430
Boston Red SoxBoston Red Sox2022129.759.5859056431,5481,37936589341200140614370311583133.265.336.423
Los Angeles DodgersLos Angeles Dodgers2022130.754.6871,1925441,7361,55139090857225157715398112667155.251.324.430
Toronto Blue JaysToronto Blue Jays2022110.754.4986166211,2371,1102846024215310971124616474104.256.327.427
Texas RangersTexas Rangers2022125.746.4758599511,8101,6324027567221914632041739705153.246.314.432
Kansas City RoyalsKansas City Royals2022129.722.4727428301,5721,409359751335183125318314713565123.255.321.401
San Francisco GiantsSan Francisco Giants2022137.722.5181,0009321,9321,71040671569242170433479316694145.237.316.406
New York MetsNew York Mets2022131.717.6001,1407591,8991,68541483652207164832376711665141.246.322.395
Cincinnati RedsCincinnati Reds2022117.713.4096539451,5981,4243517334217413103238645556118.246.323.390
Seattle MarinersSeattle Mariners2022131.711.5721,0177601,7771,54035971750196190727410316594128.233.325.386
Tampa Bay RaysTampa Bay Rays2022123.710.5708146151,4291,2993327443116211441029615507109.256.319.390
San Diego PadresSan Diego Padres2022132.704.5811,0867821,8681,66040673848198166621382714639129.245.319.385
Chicago CubsChicago Cubs2022119.702.4326498531,5021,34331468104414911842335999534122.234.305.398
Detroit TigersDetroit Tigers2022113.701.4757298071,5361,4093727762817010158341315545111.264.314.387
Minnesota TwinsMinnesota Twins2022126.701.5249038201,7231,54037078647174146317376515601131.240.310.390
Washington NationalsWashington Nationals2022127.680.3316451,3041,9491,75943282940202148319397913652131.246.309.371
Milwaukee BrewersMilwaukee Brewers2022122.673.5258968121,7081,5033336344815416243144048548115.222.309.365
Baltimore OriolesBaltimore Orioles2022123.663.5449307791,7091,5403456584614713822443215564119.224.297.366
Los Angeles AngelsLos Angeles Angels2022125.659.4678609801,8401,667377599541631405124351110616122.226.289.370
Arizona DiamondbacksArizona Diamondbacks2022132.655.4948358551,6901,5273477673916612941539279554122.227.292.363
Pittsburgh PiratesPittsburgh Pirates2022132.648.3827191,1641,8831,7193797185517813051849788631134.220.281.367
Cleveland GuardiansCleveland Guardians2022120.645.6299915841,5751,42033963326147111102432771348692.239.302.342
Oakland AthleticsOakland Athletics2022115.637.3755749581,5321,38130469335155117216345612484107.220.286.350
Miami MarlinsMiami Marlins2022104.598.4686157001,3151,19424952029109924163643738881.209.273.325
StatMuse has event-level data for OPS going back to the 1974 season.
Some of the information used here was obtained free of charge from Retrosheet.