Jimmie Foxx has the most career RBIs against the Yankees, with 246 RBIs.

	NAME	RBI	G	AB	R	H	2B	3B	HR	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Jimmie Foxx J. Foxx	246	302	1,077	195	326	45	20	70	173	2	190	10		1,260	621	135	8			10	.303	.400	.577	.977
2	Al Simmons A. Simmons	231	304	1,202	188	374	72	12	45	81	7	143	9		1,311	605	129	21			2	.311	.358	.503	.861
3	Ted Williams T. Williams	229	327	1,035	225	357	72	7	62	309	3	99	2	2	1,351	629	141	0	4	12	39	.345	.495	.608	1.103
4	Goose Goslin G. Goslin	227	334	1,266	205	375	64	30	46	121	4	109	19		1,409	637	140	18				.296	.359	.503	.863
5	Al Kaline A. Kaline	195	345	1,215	199	380	60	9	39	164	6	100	15	6	1,408	575	108	5	18	18	36	.313	.392	.473	.865
6	Charlie Gehringer C. Gehringer	195	344	1,301	251	420	74	23	33	194	2	71	19		1,509	639	130	12			6	.323	.411	.491	.903
7	Mickey Vernon M. Vernon	193	334	1,175	136	302	48	16	38	145	11	136	13	7	1,343	496	102	10	2	3	32	.257	.344	.422	.766
8	Joe Cronin J. Cronin	193	291	1,046	164	319	59	22	30	141	3	105	10		1,218	512	111	28			6	.305	.389	.489	.879
9	Vic Wertz V. Wertz	182	254	851	125	231	33	7	41	116	6	140	1	4	986	401	81	6	7	3	22	.271	.360	.471	.831
10	Hank Greenberg H. Greenberg	179	190	730	144	243	63	11	53	93	1	130	10		826	487	127	2			14	.333	.409	.667	1.076
11	Earl Averill E. Averill	174	247	950	177	307	51	16	41	106	7	97	11		1,070	513	108	7			2	.323	.395	.540	.935
12	David Ortiz D. Ortiz	171	243	894	150	271	75	1	53	142	3	175	2	0	1,055	507	129	0	16	24	28	.303	.394	.567	.961
13	Bob Johnson B. Johnson	170	276	1,018	152	292	48	15	36	140	4	139	15		1,165	478	99	3			12	.287	.375	.470	.845
14	Manny Ramirez M. Ramirez	165	203	733	139	236	51	0	55	110	10	158	2	3	861	452	106	0	8	25	25	.322	.413	.617	1.030
15	Harry Heilmann H. Heilmann	164	208	779	140	292	43	30	13	86	1	51	11		899	434	86	33				.375	.438	.557	.995
16	Carl Yastrzemski C. Yastrzemski	163	329	1,243	182	352	50	13	52	155	2	143	18	10	1,411	584	115	2	9	26	36	.283	.361	.470	.831
17	Brooks Robinson B. Robinson	154	328	1,173	131	306	49	6	34	84	2	86	2	3	1,283	469	89	13	11	22	33	.261	.309	.400	.708
18	Harmon Killebrew H. Killebrew	154	241	830	116	206	33	4	47	139	1	163	6	2	984	388	84	0	14	14	25	.248	.352	.467	.819
19	Heinie Manush H. Manush	154	264	1,053	207	359	71	19	19	59	5	57	17		1,142	525	109	25				.341	.379	.499	.877
20	Rudy York R. York	150	225	816	105	224	32	11	33	104	1	124	3		925	377	76	4			13	.275	.357	.462	.819
21	Vern Stephens V. Stephens	149	232	840	121	214	31	5	35	81	1	103	5	1	925	360	71	3	0	0	28	.255	.321	.429	.750
22	Bobby Doerr B. Doerr	149	269	988	125	257	40	10	26	105	2	97	2	1	1,114	395	76	19			29	.260	.332	.400	.732
23	Luke Appling L. Appling	147	351	1,260	184	380	57	11	8	211	1	76	20		1,480	483	76	8			18	.302	.402	.383	.786
24	Jimmy Dykes J. Dykes	147	327	1,177	143	307	52	17	23	140	14	151	12		1,359	462	92	28				.261	.346	.393	.739
25	Joe Kuhel J. Kuhel	140	297	1,091	156	277	43	9	29	138	0	115	15		1,245	425	81	16			12	.254	.338	.390	.727