Randy Johnson has struck out the most career batters at home in the 2nd inning, with 399 strikeouts.
| NAME | SO | G | H | HR | BB | HBP | IBB | K/BB | ||
|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Johnson | 399 | 314 | 221 | 29 | 88 | 17 | 1 | 4.53 |
| 2 |  | R. Clemens | 389 | 366 | 301 | 28 | 92 | 19 | 3 | 4.23 |
| 3 |  | N. Ryan | 374 | 328 | 226 | 19 | 163 | 8 | 1 | 2.29 |
| 4 |  | J. Verlander | 297 | 278 | 208 | 24 | 56 | 4 | 1 | 5.30 |
| 5 |  | C. Kershaw | 286 | 228 | 161 | 19 | 45 | 3 | 2 | 6.36 |
| 6 |  | CC Sabathia | 286 | 274 | 248 | 26 | 78 | 7 | 1 | 3.67 |
| 7 |  | M. Scherzer | 273 | 230 | 167 | 24 | 47 | 5 | 3 | 5.81 |
| 8 |  | Z. Greinke | 262 | 277 | 250 | 21 | 66 | 3 | 1 | 3.97 |
| 9 |  | M. Mussina | 248 | 273 | 265 | 38 | 62 | 5 | 1 | 4.00 |
| 10 | | C. Schilling | 246 | 222 | 193 | 18 | 34 | 1 | 0 | 7.24 |
| 11 |  | J. Smoltz | 246 | 238 | 201 | 18 | 73 | 2 | 1 | 3.37 |
| 12 |  | G. Maddux | 244 | 369 | 314 | 28 | 63 | 9 | 12 | 3.87 |
| 13 |  | P. Martinez | 241 | 192 | 131 | 18 | 46 | 10 | 2 | 5.24 |
| 14 | | F. Tanana | 236 | 310 | 269 | 28 | 91 | 10 | 6 | 2.59 |
| 15 | | A.J. Burnett | 229 | 208 | 171 | 22 | 92 | 11 | 2 | 2.49 |
| 16 | | J. Vazquez | 226 | 216 | 202 | 26 | 62 | 9 | 6 | 3.65 |
| 17 | | T. Glavine | 224 | 332 | 291 | 26 | 92 | 2 | 11 | 2.43 |
| 18 |  | C. Morton | 221 | 208 | 169 | 25 | 75 | 11 | 2 | 2.95 |
| 19 | | J. Moyer | 220 | 326 | 278 | 35 | 77 | 9 | 2 | 2.86 |
| 20 |  | J. Lester | 218 | 225 | 232 | 29 | 82 | 4 | 2 | 2.66 |
| 21 |  | B. Colon | 218 | 274 | 269 | 42 | 72 | 4 | 4 | 3.03 |
| 22 |  | S. Carlton | 216 | 223 | 153 | 14 | 83 | 1 | 0 | 2.60 |
| 23 | | C. Finley | 215 | 234 | 189 | 20 | 78 | 9 | 2 | 2.76 |
| 24 | | D. Cone | 214 | 204 | 172 | 24 | 87 | 10 | 4 | 2.46 |
| 25 | | B. Blyleven | 213 | 282 | 237 | 19 | 76 | 8 | 1 | 2.80 |
StatMuse has event-level data for strikeouts going back to the 1974 season.
Some of the information used here was obtained free of charge from Retrosheet.
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