Randy Johnson has struck out the most career batters at home in the 3rd inning, with 379 strikeouts.
| NAME | SO | G | H | HR | BB | HBP | IBB | K/BB | ||
|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Johnson | 379 | 311 | 225 | 22 | 119 | 10 | 1 | 3.18 |
| 2 |  | R. Clemens | 365 | 362 | 293 | 19 | 89 | 9 | 2 | 4.10 |
| 3 |  | N. Ryan | 333 | 323 | 208 | 14 | 143 | 14 | 7 | 2.33 |
| 4 |  | J. Verlander | 285 | 276 | 227 | 22 | 81 | 6 | 0 | 3.52 |
| 5 |  | M. Scherzer | 268 | 229 | 157 | 24 | 65 | 9 | 1 | 4.12 |
| 6 |  | G. Maddux | 263 | 369 | 326 | 22 | 69 | 14 | 10 | 3.81 |
| 7 |  | Z. Greinke | 256 | 276 | 212 | 25 | 60 | 6 | 2 | 4.27 |
| 8 |  | C. Kershaw | 238 | 225 | 179 | 20 | 49 | 1 | 0 | 4.86 |
| 9 |  | CC Sabathia | 228 | 274 | 256 | 30 | 93 | 4 | 2 | 2.45 |
| 10 |  | C. Schilling | 225 | 222 | 190 | 16 | 35 | 5 | 1 | 6.43 |
| 11 | | C. Hamels | 216 | 204 | 156 | 20 | 55 | 6 | 2 | 3.93 |
| 12 |  | P. Martinez | 216 | 191 | 130 | 9 | 44 | 14 | 1 | 4.91 |
| 13 | | F. Tanana | 216 | 304 | 303 | 38 | 94 | 7 | 9 | 2.30 |
| 14 |  | S. Carlton | 215 | 223 | 169 | 13 | 94 | 2 | 2 | 2.29 |
| 15 | | A.J. Burnett | 214 | 209 | 176 | 20 | 76 | 10 | 2 | 2.82 |
| 16 |  | J. Smoltz | 212 | 236 | 208 | 11 | 60 | 5 | 5 | 3.53 |
| 17 | | C. Finley | 212 | 234 | 194 | 20 | 91 | 4 | 1 | 2.33 |
| 18 |  | F. Hernandez | 211 | 209 | 174 | 18 | 51 | 7 | 1 | 4.14 |
| 19 | | M. Mussina | 205 | 272 | 246 | 36 | 46 | 5 | 2 | 4.46 |
| 20 | | T. Glavine | 204 | 329 | 306 | 24 | 104 | 5 | 10 | 1.96 |
| 21 | | K. Brown | 203 | 238 | 208 | 18 | 56 | 15 | 2 | 3.63 |
| 22 |  | J. Lester | 200 | 224 | 204 | 21 | 62 | 7 | 1 | 3.23 |
| 23 |  | C. Morton | 199 | 203 | 182 | 23 | 65 | 13 | 2 | 3.06 |
| 24 | | J. Moyer | 199 | 325 | 280 | 24 | 78 | 13 | 4 | 2.55 |
| 25 | | B. Blyleven | 198 | 278 | 230 | 27 | 77 | 9 | 3 | 2.57 |
StatMuse has event-level data for strikeouts going back to the 1974 season.
Some of the information used here was obtained free of charge from Retrosheet.
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