Since 1940, Phil Niekro has pitched the most innings, with 5404 innings.

	NAME	IP	G	W	L	W%	GS	ERA	SO	CG	SHO	SV	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Phil Niekro P. Niekro	5404.0	864	318	274	.537	716	3.35	3,342	245	45	29	5,044	2,012	2,337	482	1,809	123	83	86	22,677	226	5.57	3.01	1.85	0.80	14.7	8.0	1.27	.270	3.89	87	3.61	95	8.40	116.1
2	Nolan Ryan N. Ryan	5386.0	807	324	292	.526	773	3.19	5,714	222	61	3	3,923	1,911	2,178	321	2,795	158	13	78	22,575	277	9.55	4.67	2.04	0.54	25.3	12.4	1.25	.265	3.64	90	2.96	83	6.56	370.2
3	Gaylord Perry G. Perry	5350.0	777	314	265	.542	690	3.11	3,534	303	53	10	4,938	1,846	2,128	399	1,379	108	33	164	21,953	160	5.95	2.32	2.56	0.67	16.1	6.3	1.18	.275	3.58	85	3.06	85	8.31	312.9
4	Don Sutton D. Sutton	5282.1	774	324	256	.559	756	3.26	3,574	178	58	5	4,692	1,914	2,104	472	1,343	82	12	102	21,631	112	6.09	2.29	2.66	0.80	16.5	6.2	1.14	.261	3.58	92	3.23	90	7.99	181.2
5	Warren Spahn W. Spahn	5243.2	750	363	245	.597	665	3.09	2,583	382	63	28	4,830	1,798	2,016	434	1,434	42	67	60	21,547	81	4.43	2.46	1.80	0.74	12.0	6.7	1.19	.258	3.46	84	3.44	94	8.29	124.4
6	Steve Carlton S. Carlton	5217.2	741	329	244	.574	709	3.22	4,136	254	55	2	4,672	1,864	2,130	414	1,833	53	13	150	21,683	183	7.13	3.16	2.26	0.71	19.1	8.5	1.25	.279	3.67	87	3.14	86	8.06	271.5
7	Greg Maddux G. Maddux	5008.1	744	355	227	.610	740	3.16	3,371	109	35	0	4,726	1,756	1,981	353	999	137	3	177	20,421	70	6.06	1.80	3.37	0.63	16.5	4.9	1.14	.281	3.56	76	3.25	78	8.49	519.5
8	Bert Blyleven B. Blyleven	4970.0	692	287	250	.534	685	3.31	3,701	242	60	0	4,632	1,830	2,029	430	1,322	155	3	71	20,491	114	6.70	2.39	2.80	0.78	18.1	6.5	1.20	.282	3.67	85	3.18	82	8.39	368.6
9	Roger Clemens R. Clemens	4916.2	709	354	184	.658	707	3.12	4,672	118	46	0	4,185	1,707	1,885	363	1,580	159	0	63	20,240	143	8.55	2.89	2.96	0.66	23.1	7.8	1.17	.284	3.45	70	3.08	71	7.66	680.4
10	Tom Seaver T. Seaver	4783.0	656	311	205	.603	647	2.86	3,640	231	61	1	3,971	1,521	1,674	380	1,390	76	6	116	19,369	126	6.85	2.62	2.62	0.72	18.8	7.2	1.12	.259	3.15	79	3.03	85	7.47	286.1
11	Tommy John T. John	4710.1	760	288	231	.555	700	3.34	2,245	162	46	3	4,783	1,749	2,017	302	1,259	98	22	102	19,692	187	4.29	2.41	1.78	0.58	11.4	6.4	1.28	.284	3.85	90	3.37	89	9.14	208.3
12	Robin Roberts R. Roberts	4688.2	676	286	245	.539	609	3.41	2,357	305	45	25	4,582	1,774	1,962	505	902	54	49	69	19,174	33	4.52	1.73	2.61	0.97	12.3	4.7	1.17	.265	3.77	89	3.50	91	8.80	179.6
13	Early Wynn E. Wynn	4543.2	688	300	242	.554	608	3.53	2,333	288	49	16	4,265	1,783	2,022	338	1,765	64	67	36	19,311	49	4.62	3.50	1.32	0.67	12.1	9.1	1.33	.265	4.01	94	3.63	97	8.45	56.7
14	Jim Kaat J. Kaat	4530.1	898	283	237	.544	625	3.45	2,461	180	31	17	4,620	1,738	2,038	395	1,083	122	102	116	19,023	128	4.89	2.15	2.27	0.78	12.9	5.7	1.26	.282	4.05	93	3.41	91	9.18	165.8
15	Fergie Jenkins F. Jenkins	4500.2	664	284	226	.557	594	3.34	3,192	267	49	7	4,142	1,669	1,853	484	997	84	37	116	18,400	62	6.38	1.99	3.20	0.97	17.3	5.4	1.14	.268	3.71	87	3.27	88	8.28	222.9
16	Tom Glavine T. Glavine	4413.1	682	305	203	.600	682	3.54	2,607	56	25	0	4,298	1,734	1,900	356	1,500	66	0	145	18,604	65	5.32	3.06	1.74	0.73	14.0	8.1	1.31	.280	3.87	86	3.94	94	8.76	120.1
17	Frank Tanana F. Tanana	4188.1	638	240	236	.504	616	3.66	2,773	143	34	1	4,063	1,704	1,910	448	1,255	129	10	116	17,641	119	5.96	2.70	2.21	0.96	15.7	7.1	1.27	.277	4.10	94	3.78	96	8.73	66.4
18	Randy Johnson R. Johnson	4135.1	618	303	166	.646	603	3.29	4,875	100	37	2	3,346	1,513	1,703	411	1,497	190	7	37	17,067	109	10.61	3.26	3.26	0.89	28.6	8.8	1.17	.291	3.71	75	3.18	73	7.28	554.3
19	Jamie Moyer J. Moyer	4074.0	696	269	209	.563	638	4.25	2,441	33	10	0	4,231	1,926	2,076	522	1,155	146	15	69	17,356	57	5.39	2.55	2.11	1.15	14.1	6.7	1.32	.283	4.59	97	4.46	102	9.35	-33.5
20	Dennis Martinez D. Martinez	3999.2	692	245	193	.559	562	3.70	2,149	122	30	8	3,897	1,643	1,835	372	1,165	122	51	71	16,754	83	4.84	2.62	1.84	0.84	12.8	7.0	1.27	.272	4.13	94	3.91	99	8.77	17
21	Jim Palmer J. Palmer	3948.0	558	268	152	.638	521	2.86	2,212	211	53	4	3,349	1,253	1,395	303	1,311	38	15	37	16,114	85	5.04	2.99	1.69	0.69	13.7	8.1	1.18	.249	3.18	80	3.50	95	7.63	83.2
22	Bob Gibson B. Gibson	3884.1	528	251	174	.591	482	2.91	3,117	255	56	6	3,279	1,258	1,420	257	1,336	102	21	118	16,068	108	7.22	3.10	2.33	0.60	19.4	8.3	1.19	.268	3.29	78	2.89	81	7.60	290.5
23	Jerry Koosman J. Koosman	3839.1	612	222	209	.515	527	3.36	2,556	140	33	17	3,635	1,433	1,608	290	1,198	71	43	121	15,996	89	5.99	2.81	2.13	0.68	16.0	7.5	1.26	.282	3.77	92	3.25	90	8.52	152.5
24	Jack Morris J. Morris	3824.0	549	254	186	.577	527	3.90	2,478	175	28	0	3,567	1,657	1,815	389	1,390	58	10	99	16,120	206	5.83	3.27	1.78	0.92	15.4	8.6	1.30	.269	4.27	96	3.93	95	8.40	93
25	Charlie Hough C. Hough	3801.1	858	216	216	.500	440	3.75	2,362	107	13	61	3,283	1,582	1,807	383	1,665	174	240	44	16,170	179	5.59	3.94	1.42	0.91	14.6	10.3	1.30	.250	4.28	95	4.28	109	7.77	-142.3