The Colorado Rockies have the lowest run differential by a team this season, with a differential of -143 runs.

Interpreted as:

worst run differential by a team this regular season

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Rockies	-143	2025	45	.178	8	37	1,489	152	327	67	13	41	151	130	16	439	21	9	1,649	543	121	4	10	4	32	.220	.288	.365	.652
2	Orioles	-85	2025	45	.333	15	30	1,485	169	343	62	6	53	160	126	22	398	24	9	1,646	576	121	1	12	2	35	.231	.298	.388	.686
3	Marlins	-66	2025	45	.400	18	27	1,535	187	380	73	6	42	179	137	13	387	39	14	1,705	591	121	9	11	5	22	.248	.313	.385	.698
4	Pirates	-62	2025	47	.319	15	32	1,552	141	337	49	7	33	138	164	16	414	49	11	1,744	499	89	4	8	7	43	.217	.297	.322	.619
5	Athletics	-61	2025	47	.468	22	25	1,608	199	404	75	6	58	192	138	7	353	21	6	1,766	665	139	3	10	2	42	.251	.311	.414	.725
6	Angels	-61	2025	44	.432	19	25	1,451	175	318	60	5	62	170	109	18	432	19	7	1,591	574	127	3	10	5	27	.219	.280	.396	.676
7	White Sox	-53	2025	47	.298	14	33	1,522	157	330	61	1	37	152	146	11	397	37	7	1,694	504	99	5	10	1	27	.217	.288	.331	.619
8	Nationals	-49	2025	48	.438	21	27	1,594	207	384	73	7	50	196	142	22	387	49	15	1,778	621	130	9	11	1	27	.241	.310	.390	.699
9	Blue Jays	-28	2025	46	.478	22	24	1,546	179	385	80	1	40	173	147	16	343	29	9	1,733	587	121	9	15	8	34	.249	.318	.380	.698
10	Guardians	-20	2025	46	.543	25	21	1,488	182	346	60	3	51	171	149	18	360	36	12	1,680	565	114	7	18	6	26	.233	.307	.380	.686
11	Rays	-9	2025	46	.457	21	25	1,541	179	373	63	3	39	171	139	10	393	57	12	1,705	559	105	0	15	0	33	.242	.306	.363	.669
12	Brewers	-7	2025	47	.468	22	25	1,544	198	352	59	4	37	179	157	20	386	59	14	1,743	530	100	11	11	6	24	.228	.305	.343	.649
13	Royals	-1	2025	48	.542	26	22	1,600	159	385	80	11	30	157	121	15	332	40	15	1,760	577	121	9	15	8	22	.241	.298	.361	.658
14	Rangers	1	2025	48	.521	25	23	1,548	166	352	59	4	50	163	123	16	373	41	10	1,702	569	113	2	13	2	26	.227	.289	.368	.656
15	Diamondbacks	2	2025	46	.522	24	22	1,559	242	401	98	8	63	235	180	21	344	42	11	1,788	704	169	8	20	6	33	.257	.338	.452	.790
16	Braves	5	2025	46	.500	23	23	1,558	185	378	63	6	49	177	154	14	390	30	9	1,739	600	118	5	8	4	25	.243	.315	.385	.700
17	Red Sox	14	2025	47	.489	23	24	1,638	230	417	86	7	59	220	160	20	432	48	12	1,831	694	152	3	10	10	21	.255	.327	.424	.750
18	Mariners	18	2025	44	.568	25	19	1,488	210	355	56	2	61	202	174	24	392	45	13	1,704	598	119	8	10	3	26	.239	.326	.402	.728
19	Astros	20	2025	46	.522	24	22	1,520	185	372	66	5	39	176	150	17	355	22	9	1,706	565	110	8	11	5	34	.245	.317	.372	.689
20	Phillies	24	2025	46	.609	28	18	1,561	216	400	70	7	46	206	175	14	365	41	8	1,764	622	123	4	10	6	31	.256	.335	.398	.733
21	Reds	30	2025	48	.500	24	24	1,611	220	391	80	3	53	212	169	18	434	52	14	1,809	636	136	3	8	4	27	.243	.320	.395	.715
22	Twins	35	2025	47	.553	26	21	1,569	194	380	78	6	45	185	132	27	385	26	9	1,738	605	129	0	10	3	28	.242	.310	.386	.696
23	Cardinals	38	2025	47	.553	26	21	1,607	224	421	91	1	45	211	161	21	359	31	10	1,808	649	137	5	14	8	38	.262	.334	.404	.738
24	Padres	43	2025	44	.614	27	17	1,464	198	384	66	6	40	180	142	12	303	36	9	1,642	582	112	10	14	5	29	.262	.330	.398	.727
25	Giants	47	2025	47	.596	28	19	1,559	222	369	75	6	50	212	165	12	404	25	11	1,756	606	131	8	12	4	24	.237	.312	.389	.701