The Colorado Rockies have the lowest run differential by a team this season, with a differential of -223 runs.

Interpreted as:

worst run differential by a team this regular season

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Rockies	-223	2025	87	.230	20	67	2,918	310	673	140	25	83	303	229	30	856	49	22	3,204	1,112	248	9	18	5	64	.231	.292	.381	.673
2	Athletics	-140	2025	89	.404	36	53	3,028	369	752	138	10	110	357	287	21	750	49	12	3,360	1,240	258	7	17	5	82	.248	.316	.410	.726
3	Orioles	-87	2025	86	.430	37	49	2,879	357	692	133	10	101	336	242	39	756	59	18	3,187	1,148	244	3	24	7	62	.240	.306	.399	.704
4	White Sox	-86	2025	86	.326	28	58	2,806	292	620	129	8	66	277	278	19	743	58	18	3,138	963	203	13	22	4	50	.221	.293	.343	.637
5	Marlins	-70	2025	85	.459	39	46	2,915	360	741	143	14	75	347	258	19	688	69	27	3,230	1,137	232	16	22	7	49	.254	.317	.390	.707
6	Nationals	-68	2025	87	.425	37	50	2,928	388	723	143	12	87	372	255	38	660	77	30	3,257	1,151	242	16	20	10	53	.247	.313	.393	.707
7	Guardians	-52	2025	85	.471	40	45	2,765	309	622	115	8	84	294	264	29	700	65	21	3,097	1,005	207	11	28	12	51	.225	.297	.363	.660
8	Angels	-46	2025	86	.500	43	43	2,876	371	659	116	10	127	357	241	46	842	38	18	3,188	1,176	253	7	18	11	51	.229	.297	.409	.706
9	Royals	-35	2025	87	.460	40	47	2,912	287	708	147	15	58	283	210	29	601	66	29	3,193	1,059	220	19	23	13	44	.243	.298	.364	.662
10	Pirates	-29	2025	88	.432	38	50	2,910	310	682	117	14	61	300	284	30	761	75	22	3,253	1,010	192	8	21	12	76	.234	.307	.347	.654
11	Twins	-18	2025	87	.471	41	46	2,910	359	693	135	8	97	346	251	51	722	43	15	3,232	1,135	240	2	18	5	57	.238	.308	.390	.698
12	Braves	9	2025	86	.453	39	47	2,908	348	708	117	9	88	335	301	24	742	43	13	3,260	1,107	214	7	20	10	53	.243	.318	.381	.698
13	Blue Jays	9	2025	87	.563	49	38	2,942	401	761	146	4	92	384	294	34	585	46	15	3,314	1,191	242	18	26	16	64	.259	.330	.405	.735
14	Diamondbacks	9	2025	86	.500	43	43	2,927	449	747	151	18	128	439	305	39	676	62	19	3,322	1,318	297	15	36	9	59	.255	.330	.450	.780
15	Padres	11	2025	86	.535	46	40	2,859	352	700	127	11	73	328	276	23	605	58	16	3,202	1,068	211	19	25	9	56	.245	.314	.374	.687
16	Red Sox	15	2025	88	.489	43	45	3,030	421	760	172	13	107	402	292	40	811	73	19	3,390	1,279	292	7	21	16	48	.251	.323	.422	.745
17	Mariners	15	2025	86	.523	45	41	2,962	392	735	118	4	112	379	297	47	753	79	22	3,343	1,197	234	15	22	14	57	.248	.324	.404	.728
18	Giants	25	2025	87	.529	46	41	2,847	359	655	130	15	81	340	310	34	730	45	17	3,234	1,058	226	18	25	6	60	.230	.311	.372	.682
19	Rangers	26	2025	87	.494	43	44	2,887	330	661	121	8	88	316	252	35	713	78	20	3,204	1,062	217	5	25	10	45	.229	.296	.368	.664
20	Cardinals	32	2025	88	.534	47	41	2,985	403	754	151	4	87	383	276	46	682	47	15	3,341	1,174	242	9	25	12	61	.253	.323	.393	.716
21	Reds	35	2025	87	.517	45	42	2,920	404	722	143	11	94	384	290	29	755	66	23	3,268	1,169	248	7	22	7	56	.247	.319	.400	.720
22	Mets	39	2025	88	.568	50	38	2,931	380	714	137	13	112	371	302	53	689	66	10	3,319	1,213	262	4	29	15	71	.244	.322	.414	.736
23	Astros	48	2025	87	.598	52	35	2,918	367	752	122	9	93	350	250	40	665	47	19	3,239	1,171	224	9	22	7	71	.258	.323	.401	.724
24	Phillies	52	2025	87	.586	51	36	2,952	399	755	135	13	92	380	301	33	686	76	16	3,314	1,192	240	9	19	10	54	.256	.330	.404	.733
25	Brewers	56	2025	87	.552	48	39	2,912	409	718	125	8	85	380	305	34	697	99	30	3,295	1,114	218	18	26	10	46	.247	.323	.383	.705