The Boston Red Sox had the lowest run differential by a team in 1932, with a differential of -345 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	AVG	OBP	SLG	OPS
1	Red Sox	-345	1932	154	.279	43	111	5,294	566	1,330	253	57	53	529	470	12	537	46	46	5,856	1,856	363	80	.251	.314	.351	.664
2	White Sox	-230	1932	152	.325	49	102	5,330	667	1,425	273	56	36	608	459	19	384	89	60	5,897	1,918	365	89	.267	.328	.360	.688
3	Browns	-164	1932	154	.409	63	91	5,448	735	1,502	274	69	67	684	507	19	528	69	63	6,064	2,115	410	90	.276	.339	.388	.728
4	Reds	-140	1932	155	.390	60	94	5,443	575	1,429	265	68	47	546	436	20	436	35		5,999	1,971	380	100	.263	.320	.362	.682
5	Cardinals	-33	1932	156	.468	72	82	5,458	684	1,467	307	51	76	626	420	25	514	92		5,972	2,104	434	69	.269	.324	.385	.709
6	Pirates	-10	1932	154	.558	86	68	5,421	701	1,543	274	90	48	653	358	31	385	71		5,906	2,141	412	96	.285	.333	.395	.727
7	Braves	-6	1932	155	.500	77	77	5,506	649	1,460	262	53	63	594	347	19	496	36		5,977	2,017	378	105	.265	.311	.366	.677
8	Dodgers	6	1932	154	.526	81	73	5,433	752	1,538	296	59	110	703	388	24	574	61		5,944	2,282	465	99	.283	.334	.420	.754
9	Tigers	12	1932	153	.503	76	75	5,409	799	1,479	291	80	80	742	486	13	521	105	49	5,992	2,170	451	84	.273	.335	.401	.736
10	Phillies	48	1932	154	.506	78	76	5,510	844	1,608	330	67	122	780	446	27	547	71		6,108	2,438	519	125	.292	.348	.442	.790
11	Giants	49	1932	154	.468	72	82	5,530	755	1,527	263	54	116	718	348	23	391	31		5,950	2,246	433	49	.276	.322	.406	.728
12	Cubs	87	1932	154	.584	90	64	5,462	720	1,519	296	60	69	665	398	28	514	48		6,006	2,142	425	118	.278	.330	.392	.722
13	Indians	101	1932	153	.572	87	65	5,412	845	1,544	310	74	78	786	566	33	454	52	54	6,121	2,236	462	110	.285	.357	.413	.770
14	Senators	124	1932	154	.604	93	61	5,515	840	1,565	303	100	61	776	505	26	442	70	48	6,141	2,251	464	95	.284	.347	.408	.755
15	Athletics	230	1932	154	.610	94	60	5,535	981	1,606	303	52	172	923	650	21	629	37	24	6,300	2,529	527	94	.290	.367	.457	.824
16	Yankees	278	1932	156	.695	107	47	5,476	1,002	1,564	279	82	160	954	765	27	526	77	66	6,344	2,487	521	76	.286	.376	.454	.830