The Tampa Bay Devil Rays had the lowest run differential by a team in 2007, with a differential of -162 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Devil Rays	-162	2007	162	.407	66	96	5,593	782	1,500	291	36	187	750	545	53	1,324	131	48	6,277	2,424	514	34	52	31	119	.268	.336	.433	.769
2	White Sox	-146	2007	162	.444	72	90	5,441	693	1,341	249	20	190	667	532	52	1,149	78	45	6,101	2,200	459	41	35	33	138	.246	.318	.404	.722
3	Pirates	-122	2007	162	.420	68	94	5,569	724	1,463	322	31	148	694	463	71	1,135	68	30	6,214	2,291	501	60	51	31	130	.263	.325	.411	.736
4	Orioles	-112	2007	162	.426	69	93	5,631	756	1,529	306	30	142	718	500	47	939	144	42	6,263	2,321	478	38	47	31	139	.272	.333	.412	.746
5	Nationals	-110	2007	162	.451	73	89	5,520	673	1,415	309	31	123	646	524	53	1,128	69	23	6,201	2,155	463	63	41	38	143	.256	.325	.390	.715
6	Cardinals	-104	2007	162	.481	78	84	5,529	725	1,513	279	13	141	690	506	54	909	56	33	6,211	2,241	433	68	54	47	154	.274	.337	.405	.743
7	Marlins	-101	2007	162	.438	71	91	5,627	790	1,504	340	38	201	749	521	82	1,332	105	34	6,344	2,523	579	72	42	46	107	.267	.336	.448	.784
8	Astros	-90	2007	162	.451	73	89	5,605	723	1,457	293	30	167	700	547	55	1,043	65	33	6,324	2,311	490	77	40	40	142	.260	.330	.412	.742
9	Royals	-72	2007	162	.426	69	93	5,534	706	1,447	300	46	102	660	428	89	1,069	78	44	6,139	2,145	448	41	47	34	151	.261	.322	.388	.710
10	Reds	-70	2007	162	.444	72	90	5,607	783	1,496	293	23	204	747	536	66	1,113	97	31	6,328	2,447	520	73	46	51	140	.267	.335	.436	.772
11	Giants	-37	2007	162	.438	71	91	5,538	683	1,407	267	37	131	641	532	39	907	119	33	6,212	2,141	435	67	36	74	142	.254	.322	.387	.708
12	Rangers	-28	2007	162	.463	75	87	5,555	816	1,460	298	36	179	768	503	56	1,224	88	25	6,213	2,367	513	57	42	27	129	.263	.328	.426	.754
13	Diamondbacks	-20	2007	162	.556	90	72	5,398	712	1,350	286	40	171	687	532	57	1,111	109	24	6,100	2,229	497	55	58	38	121	.250	.321	.413	.734
14	Mariners	-19	2007	162	.543	88	74	5,684	794	1,629	284	22	153	754	389	62	861	81	30	6,208	2,416	459	33	40	32	154	.287	.337	.425	.762
15	Athletics	-17	2007	162	.469	76	86	5,577	741	1,430	295	16	171	711	664	49	1,119	52	20	6,364	2,270	482	18	56	29	142	.256	.338	.407	.745
16	Twins	-7	2007	162	.488	79	83	5,522	718	1,460	273	36	118	671	512	48	839	112	30	6,161	2,159	427	34	45	41	149	.264	.330	.391	.721
17	Dodgers	8	2007	162	.506	82	80	5,614	735	1,544	276	35	129	706	511	41	864	137	50	6,279	2,277	440	58	55	41	116	.275	.337	.406	.743
18	Brewers	25	2007	162	.512	83	79	5,554	801	1,455	310	37	231	774	501	76	1,137	96	32	6,238	2,532	578	60	47	60	112	.262	.329	.456	.785
19	Mets	54	2007	162	.543	88	74	5,605	804	1,543	294	27	177	761	549	54	981	200	46	6,343	2,422	498	77	58	64	114	.275	.342	.432	.775
20	Blue Jays	54	2007	162	.512	83	79	5,536	753	1,434	344	24	165	719	533	47	1,044	57	22	6,197	2,321	533	33	48	32	127	.259	.327	.419	.746
21	Cubs	62	2007	162	.525	85	77	5,643	752	1,530	340	28	151	711	500	40	1,054	86	33	6,268	2,379	519	48	37	48	127	.271	.333	.422	.754
22	Phillies	71	2007	162	.549	89	73	5,688	892	1,558	326	41	213	850	641	90	1,205	138	19	6,536	2,605	580	65	52	74	125	.274	.354	.458	.812
23	Padres	75	2007	163	.546	89	74	5,612	741	1,408	322	31	171	704	557	49	1,229	55	24	6,326	2,305	524	64	44	45	113	.251	.322	.411	.732
24	Braves	77	2007	162	.519	84	78	5,689	810	1,562	328	27	176	781	534	49	1,149	64	30	6,374	2,472	531	55	47	43	137	.275	.339	.435	.774
25	Tigers	90	2007	162	.543	88	74	5,757	887	1,652	352	50	177	857	474	56	1,054	103	30	6,363	2,635	579	31	45	45	128	.287	.345	.458	.802