The San Diego Padres had the lowest run differential by a team in 2017, with a differential of -212 runs.

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Padres	-212	2017	162	.438	71	91	5,356	604	1,251	227	31	189	576	460	53	1,499	89	33	5,954	2,107	447	52	33	20	99	.234	.299	.393	.692
2	Tigers	-159	2017	162	.395	64	98	5,556	735	1,435	289	35	187	699	503	52	1,313	65	34	6,149	2,355	511	11	27	21	128	.258	.324	.424	.748
3	Giants	-137	2017	162	.395	64	98	5,551	639	1,382	290	28	128	612	467	36	1,204	76	34	6,137	2,112	446	31	52	37	136	.249	.309	.380	.689
4	Mets	-128	2017	162	.432	70	92	5,510	735	1,379	286	28	224	713	529	57	1,291	58	23	6,169	2,393	538	36	37	31	118	.250	.320	.434	.755
5	Reds	-116	2017	162	.420	68	94	5,484	753	1,390	249	38	219	715	565	72	1,329	120	39	6,213	2,372	506	50	42	41	116	.253	.329	.433	.761
6	White Sox	-114	2017	162	.414	67	95	5,513	706	1,412	256	37	186	670	401	76	1,397	71	31	6,058	2,300	479	35	33	17	124	.256	.314	.417	.731
7	Orioles	-98	2017	162	.463	75	87	5,650	743	1,469	269	12	232	713	392	50	1,412	32	13	6,139	2,458	513	10	37	12	138	.260	.312	.435	.747
8	Phillies	-92	2017	162	.407	66	96	5,535	690	1,382	287	36	174	654	494	47	1,417	59	25	6,133	2,263	497	21	36	25	128	.250	.315	.409	.723
9	Blue Jays	-91	2017	162	.469	76	86	5,499	693	1,320	269	5	222	661	542	51	1,327	53	24	6,152	2,265	496	25	35	12	153	.240	.312	.412	.724
10	Braves	-89	2017	162	.444	72	90	5,584	732	1,467	289	26	165	706	474	66	1,184	77	31	6,215	2,303	480	59	32	57	137	.263	.326	.412	.738
11	Royals	-89	2017	162	.494	80	82	5,536	702	1,436	260	24	193	660	390	45	1,166	91	31	6,025	2,323	477	17	37	19	160	.259	.311	.420	.731
12	Athletics	-87	2017	162	.463	75	87	5,464	739	1,344	305	15	234	708	565	43	1,491	57	22	6,125	2,381	554	13	40	15	129	.246	.319	.436	.755
13	Pirates	-63	2017	162	.463	75	87	5,458	668	1,331	249	36	151	635	519	88	1,213	67	36	6,135	2,105	436	42	28	39	120	.244	.318	.386	.704
14	Marlins	-44	2017	162	.475	77	85	5,602	778	1,497	271	31	194	743	486	67	1,282	91	30	6,246	2,412	496	50	41	48	119	.267	.331	.431	.761
15	Mariners	-22	2017	162	.481	78	84	5,551	750	1,436	281	17	200	714	487	78	1,267	89	35	6,165	2,351	498	14	35	31	131	.259	.325	.424	.749
16	Rangers	-17	2017	162	.481	78	84	5,430	799	1,326	255	21	237	756	544	81	1,493	113	44	6,121	2,334	513	27	39	18	110	.244	.320	.430	.750
17	Rays	-10	2017	162	.494	80	82	5,478	694	1,340	226	32	228	671	545	55	1,538	88	34	6,142	2,314	486	16	48	33	115	.245	.317	.422	.739
18	Angels	1	2017	162	.494	80	82	5,415	710	1,314	251	14	186	678	523	70	1,198	136	44	6,071	2,151	451	17	46	30	141	.243	.315	.397	.712
19	Twins	27	2017	162	.525	85	77	5,557	815	1,444	286	31	206	781	593	46	1,342	95	28	6,261	2,410	523	26	39	26	105	.260	.334	.434	.768
20	Brewers	35	2017	162	.531	86	76	5,467	732	1,363	267	22	224	695	547	53	1,571	128	41	6,135	2,346	513	42	26	34	116	.249	.322	.429	.751
21	Cardinals	56	2017	162	.512	83	79	5,470	761	1,402	284	28	196	728	593	65	1,348	81	31	6,219	2,330	508	47	44	36	139	.256	.334	.426	.760
22	Rockies	67	2017	162	.537	87	75	5,534	824	1,510	293	38	192	793	519	44	1,408	59	34	6,200	2,455	523	62	41	46	143	.273	.338	.444	.781
23	Red Sox	117	2017	162	.574	93	69	5,669	785	1,461	302	19	168	735	571	53	1,224	106	31	6,338	2,305	489	9	36	48	141	.258	.329	.407	.736
24	Cubs	127	2017	162	.568	92	70	5,496	822	1,402	274	29	223	785	622	82	1,401	62	31	6,280	2,403	526	48	32	54	134	.255	.338	.437	.775
25	Nationals	147	2017	162	.599	97	65	5,553	819	1,477	311	31	215	796	542	31	1,327	108	30	6,214	2,495	557	43	45	56	116	.266	.332	.449	.782