Between the 1882 and 1931 seasons, Ty Cobb had the most runs, with 2,244 runs.

	NAME	R	G	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	PA	TB	XBH	SH	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Ty Cobb T. Cobb	2,244	3,034	11,434	4,189	724	295	117	1,933	1,249	94	681	897	13,068	5,854	1,136	291	.366	.433	.512	.945	2534	1,093.6	.445	165	975.1
2	Tristram Speaker T. Speaker	1,882	2,789	10,195	3,514	792	222	117	1,531	1,381	103	394	436	11,988	5,101	1,131	309	.345	.428	.500	.928	2264	921	.436	157	812.3
3	Babe Ruth B. Ruth	1,866	2,080	7,046	2,461	455	124	611	1,877	1,694	37	1,091	116	8,890	4,997	1,190	113	.349	.478	.709	1.187	2336	1,257.3	.522	202	1,201.9
4	Eddie Collins E. Collins	1,821	2,826	9,949	3,315	438	187	47	1,300	1,499	77	468	741	12,037	4,268	672	512	.333	.424	.429	.853	2032	693.4	.409	144	619.7
5	Honus Wagner H. Wagner	1,739	2,794	10,439	3,420	643	252	101	1,732	963	125	735	723	11,748	4,870	996	221	.328	.391	.467	.858	2044	725.8	.408	147	650
6	Jesse Burkett J. Burkett	1,720	2,067	8,426	2,850	320	182	75	952	1,029	75	561	389	9,620	3,759	577	90	.338	.415	.446	.861	1921	592.9	.411	137	526.7
7	Willie Keeler W. Keeler	1,719	2,123	8,591	2,932	241	145	33	810	524	129	136	495	9,610	3,562	419	366	.341	.388	.415	.802	1640	406.6	.383	124	330.8
8	Billy Hamilton B. Hamilton	1,697	1,594	6,283	2,164	242	95	40	742	1,189	89	271	914	7,608	2,716	377	47	.344	.455	.432	.888	1716	578.6	.433	142	505.5
9	Bid McPhee B. McPhee	1,684	2,138	8,304	2,258	303	189	53	935	982	69	260	568	9,429	3,098	545	56	.272	.355	.373	.728	1594	183	.350	108	117.7
10	Jimmy Ryan J. Ryan	1,643	2,014	8,172	2,513	451	157	118	1,093	804	83	295	419	9,124	3,632	726	65	.308	.375	.444	.820	1709	379	.387	119	266.7
11	George Van Haltren G. Van Haltren	1,642	1,990	8,043	2,544	286	161	69	1,015	871	38	385	583	9,017	3,359	516	65	.316	.386	.418	.803	1647	328.4	.384	119	259.3
12	Fred Clarke F. Clarke	1,622	2,246	8,584	2,678	361	220	67	1,015	875	154	511	509	9,838	3,680	648	225	.312	.386	.429	.814	1663	445.8	.390	131	386.2
13	Jake Beckley J. Beckley	1,602	2,389	9,538	2,934	473	244	87	1,578	616	183	442	315	10,504	4,156	804	167	.308	.361	.436	.797	1803	356.2	.376	119	288.8
14	Ed Delahanty E. Delahanty	1,600	1,837	7,511	2,597	522	186	101	1,466	741	94	366	455	8,400	3,794	809	54	.346	.411	.505	.916	1836	616.8	.428	144	559.3
15	Bill Dahlen B. Dahlen	1,590	2,444	9,036	2,461	413	163	84	1,234	1,064	140	759	548	10,405	3,452	660	165	.272	.358	.382	.740	1589	236.5	.357	108	139.6
16	Hugh Duffy H. Duffy	1,554	1,737	7,044	2,293	325	119	106	1,302	664	29	186	574	7,841	3,174	550	104	.326	.386	.451	.837	1526	360.4	.395	118	242.5
17	Rogers Hornsby R. Hornsby	1,547	2,127	7,915	2,855	524	169	295	1,527	996	43	653	134	9,170	4,602	988	216	.361	.435	.581	1.016	1969	887.1	.462	175	854.9
18	Max Carey M. Carey	1,545	2,476	9,363	2,665	419	159	70	802	1,040	77	695	738	10,770	3,612	648	290	.285	.361	.386	.747	1411	179.3	.357	110	128.3
19	George Davis G. Davis	1,545	2,372	9,045	2,665	453	163	73	1,440	874	75	579	619	10,178	3,663	689	184	.295	.362	.405	.767	1643	293.1	.366	117	266.9
20	Tom Brown T. Brown	1,521	1,788	7,372	1,951	238	138	64	649	748	33	508	657	8,205	2,657	440	39	.265	.336	.360	.697	1268	26.6	.334	100	-9.8
21	Roger Connor R. Connor	1,512	1,830	7,090	2,247	406	219	133	1,071	974	39	151	244	8,112	3,490	758	9	.317	.402	.492	.895	1819	594.5	.414	143	540.9
22	Nap Lajoie N. Lajoie	1,504	2,480	9,589	3,243	657	163	82	1,599	516	134	347	380	10,460	4,472	902	221	.338	.380	.466	.847	1787	600.2	.401	144	547
23	Arlie Latham A. Latham	1,472	1,607	6,753	1,826	242	84	27	560	588	68	163	742	7,444	2,317	353	18	.270	.337	.343	.680	1155	26.5	.328	96	-46.4
24	Herman Long H. Long	1,456	1,875	7,678	2,129	342	97	91	1,055	612	57	365	537	8,505	2,938	530	158	.277	.335	.383	.718	1254	19.3	.342	92	-80.3
25	Dan Brouthers D. Brouthers	1,446	1,566	6,261	2,162	430	195	94	994	820	105	83	256	7,206	3,264	719	20	.345	.430	.521	.951	1781	698.8	.440	156	628.7