Adam Dunn has the most career strikeouts per plate appearance when making 8,000+ plate appearances, with 0.29.

	NAME	SO/PA	PA	SO	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SB	CS	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Adam Dunn A. Dunn	0.29	8,328	2,379	2,001	6,883	1,097	1,631	334	10	462	1,168	1,317	86	63	25	3,371	806	2	40	122	100	.237	.364	.490	.854	1285	297.9	.367	123	240
2	Jim Thome J. Thome	0.25	10,313	2,548	2,543	8,422	1,583	2,328	451	26	612	1,699	1,747	69	19	20	4,667	1,089	1	74	173	165	.276	.402	.554	.956	1925	653.9	.406	145	589.5
3	Jose Canseco J. Canseco	0.24	8,129	1,942	1,887	7,057	1,186	1,877	340	14	462	1,407	906	84	200	88	3,631	816	1	81	63	178	.266	.353	.515	.867	1293	321.2	.375	130	300.8
4	Sammy Sosa S. Sosa	0.23	9,896	2,306	2,354	8,813	1,475	2,408	379	45	609	1,667	929	59	234	107	4,704	1,033	17	78	154	202	.273	.344	.534	.878	1559	345.1	.370	124	307.3
5	Curtis Granderson C. Granderson	0.23	8,306	1,916	2,057	7,236	1,217	1,800	346	95	344	937	924	67	153	50	3,368	785	30	49	31	64	.249	.337	.465	.803	1149	173.1	.347	115	147.8
6	Nelson Cruz N. Cruz	0.23	8,387	1,916	2,055	7,501	1,090	2,053	372	15	464	1,325	738	86	84	32	3,847	851	2	60	78	179	.274	.343	.513	.856	1294	313.6	.363	129	286.2
7	Reggie Jackson R. Jackson	0.23	11,416	2,597	2,820	9,864	1,551	2,584	463	49	563	1,702	1,375	96	228	115	4,834	1,075	13	68	164	183	.262	.356	.490	.846	1749	503	.374	139	497.6
8	Paul Goldschmidt P. Goldschmidt	0.23	8,705	1,962	2,040	7,517	1,269	2,166	472	24	372	1,227	1,081	51	174	36	3,802	868	0	56	121	173	.288	.379	.506	.885	1452	432.7	.376	137	388.2
9	Andres Galarraga A. Galarraga	0.22	8,916	2,003	2,257	8,096	1,195	2,333	444	32	399	1,425	583	178	128	81	4,038	875	1	58	106	179	.288	.347	.499	.846	1355	286.5	.365	118	193.8
10	Bobby Bonds B. Bonds	0.22	8,090	1,757	1,849	7,043	1,258	1,886	302	66	332	1,024	914	53	461	169	3,316	700	16	64	75	107	.268	.353	.471	.824	1192	318.7	.368	130	274.9
11	Alfonso Soriano A. Soriano	0.21	8,395	1,803	1,975	7,750	1,152	2,095	481	31	412	1,159	496	86	289	84	3,874	924	9	54	68	123	.270	.319	.500	.819	1163	161.7	.348	111	112.7
12	Willie Stargell W. Stargell	0.21	9,026	1,936	2,360	7,927	1,194	2,232	423	55	475	1,540	937	78	17	16	4,190	953	9	75	227	143	.282	.360	.529	.889	1471	511.5	.387	145	459.3
13	Evan Longoria E. Longoria	0.21	8,206	1,696	1,986	7,306	1,017	1,930	431	26	342	1,159	730	72	58	19	3,439	799	1	97	87	206	.264	.333	.471	.804	1119	163.4	.343	118	170.3
14	Andruw Jones A. Jones	0.2	8,664	1,748	2,196	7,599	1,204	1,933	383	36	434	1,289	891	97	152	59	3,690	853	6	71	69	192	.254	.337	.486	.823	1229	161.4	.352	111	122.2
15	Carlos Delgado C. Delgado	0.2	8,657	1,745	2,035	7,283	1,241	2,038	483	18	473	1,512	1,109	172	14	8	3,976	974	0	93	186	152	.280	.383	.546	.929	1513	435.7	.391	135	394
16	Andrew McCutchen A. McCutchen	0.2	9,579	1,868	2,231	8,243	1,277	2,242	445	50	330	1,135	1,164	94	220	90	3,777	825	3	75	71	142	.272	.365	.458	.824	1427	314.6	.357	126	291.8
17	Dale Murphy D. Murphy	0.19	9,040	1,748	2,180	7,960	1,197	2,111	350	39	398	1,266	986	28	161	68	3,733	787	6	60	159	209	.265	.346	.469	.815	1291	273.7	.357	119	202.4
18	Lee May L. May	0.19	8,219	1,570	2,071	7,609	959	2,031	340	31	354	1,244	487	49	39	35	3,495	725	9	65	85	219	.267	.313	.459	.772	1053	174.1	.343	116	143.5
19	Freddie Freeman F. Freeman	0.19	9,196	1,738	2,140	7,964	1,356	2,389	537	32	357	1,298	1,055	111	101	32	4,061	926	0	66	140	169	.300	.387	.510	.897	1570	496.6	.381	142	464.5
20	Devon White D. White	0.19	8,080	1,526	1,941	7,344	1,125	1,934	378	71	208	846	541	87	346	98	3,078	657	61	47	32	98	.263	.319	.419	.739	964	1.2	.326	98	-22
21	Joey Votto J. Votto	0.19	8,746	1,640	2,056	7,252	1,171	2,135	459	22	356	1,144	1,365	81	80	29	3,706	837	0	48	147	168	.294	.409	.511	.920	1563	539.6	.394	145	472.9
22	Alex Rodriguez A. Rodriguez	0.19	12,207	2,287	2,784	10,566	2,021	3,115	548	31	696	2,086	1,338	176	329	76	5,813	1,275	16	111	97	261	.295	.380	.550	.930	2178	690.1	.395	141	629.5
23	Mike Schmidt M. Schmidt	0.19	10,062	1,883	2,404	8,352	1,506	2,234	408	59	548	1,595	1,507	79	174	92	4,404	1,015	16	108	201	156	.267	.380	.527	.908	1717	591	.395	147	539.8
24	Manny Ramirez M. Ramirez	0.19	9,774	1,813	2,302	8,244	1,544	2,574	547	20	555	1,831	1,329	109	38	33	4,826	1,122	2	90	216	243	.312	.411	.585	.996	1931	719.5	.418	153	658.7
25	Fred McGriff F. McGriff	0.18	10,174	1,882	2,460	8,757	1,349	2,490	441	24	493	1,550	1,305	39	72	38	4,458	958	2	71	171	226	.284	.377	.509	.886	1678	454.1	.383	134	415.9