Since April 26, 2025, the Chicago White Sox have the best record against the run line by a team, with a run-line record of 81-55.

	TEAM	ATS	ATS COV %	ATS AVG	O/U REC	O/U AVG	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	White Sox	81-55	59.6	+0.9	62-66-8	+0.3	136	.397	54	82	4,538	564	1,078	212	9	145	546	413	44	1,139	69	15	5,045	1,743	366	20	30	7	95	.238	.305	.384	.690
2	Marlins	81-56	59.1	+0.4	63-70-4	+0.9	137	.489	67	70	4,674	595	1,162	224	27	133	570	405	45	1,018	116	35	5,173	1,839	384	12	37	9	84	.249	.312	.393	.706
3	Pirates	78-57	57.8	+0.4	53-77-5	-0.5	135	.444	60	75	4,475	487	1,044	213	16	97	466	433	44	1,185	82	29	4,990	1,580	326	12	26	14	98	.233	.306	.353	.659
4	Brewers	78-61	56.1	+0.9	70-65-4	+0.7	139	.619	86	53	4,734	691	1,234	238	14	145	651	488	63	1,082	128	46	5,347	1,935	397	19	43	12	87	.261	.335	.409	.744
5	Guardians	78-63	55.3	+0.2	58-76-7	-0.2	141	.532	75	66	4,621	557	1,032	217	16	143	539	425	51	1,180	112	30	5,158	1,710	376	26	35	28	65	.223	.294	.370	.664
6	Red Sox	75-63	54.3	+0.6	64-70-4	+0.4	138	.551	76	62	4,734	668	1,208	275	21	159	635	425	63	1,192	110	33	5,271	2,002	455	14	35	16	89	.255	.323	.423	.746
7	Blue Jays	76-64	54.3	+0.5	79-54-7	+1.4	140	.600	84	56	4,789	740	1,301	259	12	186	717	446	54	940	60	20	5,357	2,142	457	30	38	24	114	.272	.338	.447	.785
8	Angels	73-64	53.3	-0.2	73-59-5	+0.5	137	.438	60	77	4,545	574	1,029	180	14	188	551	429	75	1,390	78	25	5,089	1,801	382	12	28	18	83	.226	.302	.396	.698
9	Padres	74-65	53.2	+0.1	59-76-4	+0.1	139	.532	74	65	4,669	604	1,166	219	17	130	574	430	54	1,003	83	25	5,236	1,809	366	43	40	14	87	.250	.318	.387	.705
10	Athletics	71-65	52.2	+0.4	64-66-6	+0.3	136	.463	63	73	4,657	618	1,175	255	12	183	600	425	43	1,217	71	24	5,172	2,003	450	17	30	14	95	.252	.319	.430	.749
11	Rangers	71-65	52.2	+0.5	63-71-2	+0	136	.485	66	70	4,617	602	1,093	209	13	145	578	429	55	1,123	113	26	5,147	1,763	367	11	35	17	74	.237	.307	.382	.689
12	Royals	70-65	51.9	+0.5	62-73	-0.3	135	.511	69	66	4,549	565	1,144	247	19	147	552	360	58	896	92	31	5,023	1,870	413	24	32	14	86	.251	.312	.411	.724
13	Phillies	71-69	50.7	+0.1	61-69-10	+0.3	140	.600	84	56	4,779	682	1,238	235	22	194	663	433	53	1,157	101	26	5,320	2,099	451	15	40	16	77	.259	.325	.439	.764
14	Cardinals	68-68	50	-0.3	67-63-6	+0.4	136	.493	67	69	4,525	566	1,090	212	8	125	536	388	80	1,115	66	22	5,049	1,693	345	22	34	9	93	.241	.310	.374	.684
15	Orioles	69-69	50	-0.2	52-84-2	+0.2	138	.471	65	73	4,636	574	1,099	221	15	160	548	413	62	1,254	108	33	5,149	1,830	396	4	34	13	84	.237	.306	.395	.701
16	Twins	68-68	50	-0.6	63-68-5	+0.6	136	.441	60	76	4,591	582	1,111	204	16	170	552	415	68	1,159	98	30	5,111	1,857	390	9	28	9	89	.242	.312	.404	.717
17	Diamondbacks	68-68	50	+0.1	65-64-7	+0.7	136	.485	66	70	4,607	654	1,163	225	34	179	635	431	70	1,124	99	34	5,192	1,993	438	31	53	17	92	.252	.322	.433	.755
18	Reds	68-70	49.3	+0.1	48-82-8	-0.1	138	.507	70	68	4,639	589	1,131	211	22	138	555	440	40	1,212	80	21	5,170	1,800	371	10	41	13	91	.244	.312	.388	.700
19	Astros	67-70	48.9	-0.4	64-68-5	+0.3	137	.540	74	63	4,674	594	1,183	218	10	163	570	392	60	1,095	65	22	5,166	1,910	391	11	29	10	107	.253	.317	.409	.726
20	Nationals	65-71	47.8	-0.3	69-58-9	+1.2	136	.397	54	82	4,574	577	1,111	224	23	134	553	365	51	1,160	105	39	5,036	1,783	381	12	34	11	90	.243	.304	.390	.694
21	Yankees	67-75	46.9	-0.3	67-72-4	+0.7	143	.573	82	61	4,834	738	1,204	224	16	239	713	555	43	1,282	113	30	5,487	2,177	479	7	48	46	90	.249	.329	.450	.779
22	Braves	64-73	46.7	-0.6	60-71-6	+0.5	137	.474	65	72	4,677	624	1,151	210	18	158	605	486	45	1,147	69	22	5,254	1,871	386	13	33	14	81	.246	.321	.400	.721
23	Rays	63-73	46.3	+0.1	60-68-8	+0.3	136	.478	65	71	4,604	604	1,156	197	13	159	574	387	41	1,174	164	43	5,083	1,856	369	16	35	10	84	.251	.313	.403	.716
24	Giants	62-73	45.9	-0.4	59-67-9	+0.5	135	.474	64	71	4,476	576	1,057	192	23	145	550	452	61	1,140	50	18	5,054	1,730	360	19	46	12	92	.236	.312	.387	.698
25	Cubs	65-77	45.8	-0.1	62-71-9	+0.2	142	.556	79	63	4,761	648	1,168	218	21	196	628	462	38	1,123	120	32	5,316	2,016	435	8	47	15	68	.245	.314	.423	.738