The New York Yankees have the highest run differential by a team, with a differential of 13,129 runs.

	TEAM	DIFF	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	13,129	19,133	.569	10,841	8,204	652,078	92,969	173,060	28,743	5,504	17,428	86,394	68,846	4,947	95,458	11,702	2,814	738,775	265,095	51,675	9,600	3,304	2,858	10,730	.265	.339	.407	.745
2	Giants	7,442	21,842	.535	11,600	10,079	745,372	100,940	195,982	31,453	7,052	15,651	90,402	68,541	5,711	100,180	16,543	3,151	834,341	288,492	54,156	11,680	3,037	4,023	10,234	.263	.328	.387	.716
3	Dodgers	6,264	21,758	.532	11,500	10,119	741,364	98,259	193,670	31,171	7,012	14,232	88,469	69,161	5,175	100,963	17,380	3,561	831,636	281,561	52,415	12,778	3,082	3,751	9,988	.261	.327	.380	.707
4	Red Sox	3,660	19,421	.518	10,020	9,318	664,680	90,731	177,330	33,277	5,612	14,689	84,151	67,030	4,840	96,198	9,685	2,568	750,509	265,898	53,578	10,601	3,358	3,007	11,592	.267	.337	.400	.737
5	Cubs	3,638	22,372	.513	11,394	10,817	765,595	103,019	200,479	33,862	7,369	15,351	88,596	68,781	5,304	105,581	15,856	3,083	855,637	295,132	56,582	13,029	2,928	3,525	9,991	.262	.326	.385	.711
6	Guardians	2,244	19,429	.513	9,913	9,425	662,139	87,799	175,197	31,261	5,506	13,990	81,157	62,849	4,861	95,185	11,963	3,404	744,702	259,440	50,757	11,476	3,377	2,561	10,562	.265	.331	.392	.723
7	Browns	2,020	1,233	.644	781	432	43,777	7,933	11,555	1,658	602	304	4,657	3,473	353	436	2,307		47,743	15,329	2,564					.264	.325	.350	.675
8	Cardinals	1,910	20,726	.513	10,566	10,029	708,888	92,705	188,327	31,944	7,052	12,928	84,755	64,396	5,235	98,722	15,053	3,622	793,661	273,159	51,924	11,984	3,158	3,780	10,182	.266	.330	.385	.715
9	Orioles	1,512	1,294	.579	730	530	45,361	8,530	13,521	1,814	865	218	6,940	4,345	992	2,952	2,993		51,317	17,719	2,897	619				.298	.372	.391	.763
10	Braves	1,507	22,335	.503	11,165	11,016	764,688	99,816	198,556	32,215	6,309	15,138	86,854	67,763	5,089	100,771	14,124	3,072	853,126	288,803	53,662	12,691	2,895	3,663	10,426	.260	.323	.378	.701
11	Grays	909	725	.612	438	278	26,572	4,037	6,764	1,084	341	98	292	1,192					27,764	8,824	1,523					.255		.332
12	Reds	774	21,959	.504	10,996	10,824	748,173	98,530	194,901	32,495	7,568	14,392	87,651	66,933	5,532	102,883	18,201	3,416	836,532	285,708	54,455	12,667	3,059	3,654	9,768	.261	.325	.382	.707
13	Astros	761	10,098	.503	5,076	5,017	342,724	43,086	87,391	16,028	2,178	8,514	40,556	32,551	2,935	63,485	7,184	3,146	384,980	133,317	26,720	4,035	2,735	3,148	7,467	.255	.323	.389	.712
14	Reds	578	269	.659	174	90	9,515	2,020	2,647	386	176	106	1,548	1,303	109	499	859		10,927	3,703	668					.278	.371	.389	.761
15	Blue Jays	430	7,671	.499	3,830	3,838	262,854	35,522	68,413	13,668	1,499	8,353	33,697	24,388	2,455	49,423	4,600	1,972	293,357	110,138	23,520	1,519	2,141	1,414	5,985	.260	.326	.419	.745
16	Athletics	356	1,219	.529	633	564	43,556	7,481	11,208	1,782	741	284	4,168	3,158	351	548	1,900		47,191	15,324	2,807					.257	.315	.352	.666
17	Tigers	334	19,456	.503	9,745	9,618	663,430	89,347	175,239	29,701	6,313	14,675	82,292	65,749	4,475	97,360	11,323	2,946	747,794	261,591	50,689	11,010	3,130	2,451	10,754	.264	.333	.394	.727
18	Outlaw Reds	237	105	.657	69	36	3,786	703	1,027	118	63	26		147		482			3,933	1,349	207					.271		.356
19	Whales	207	312	.565	173	133	10,231	1,262	2,634	412	127	102	1,102	964	71	1,200	332		11,614	3,606	641	348				.257	.326	.352	.678
20	Dark Blues	198	129	.619	78	48	5,022	770	1,348	159	53	6		69					5,091	1,631	218					.268		.325
21	Peppers	163	312	.551	168	137	10,273	1,347	2,757	440	170	50	1,116	908	72	1,160	457		11,678	3,687	660	425				.268	.332	.359	.691
22	Giants	143	132	.565	74	57	4,913	1,018	1,393	204	97	66	793	486	31	364	231		5,430	1,989	367					.284	.352	.405	.757
23	Brown Stockings	123	124	.589	73	51	4,656	670	1,173	124	63	3		116					4,772	1,432	190					.252		.308
24	Pirates	116	138	.547	75	62	4,968	886	1,311	200	95	31	705	492	43	410	276		5,503	1,794	326					.264	.335	.361	.697
25	Maroons	90	351	.504	173	170	12,293	1,824	3,081	563	108	70	684	630			156		12,923	4,070	741					.251		.331