Ted Williams has the most career home runs per strikeout when making 1,000+ plate appearances, with 521.

	NAME	HR/SO	PA	HR	SO	G	AB	R	H	2B	3B	RBI	BB	HBP	SB	CS	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Ted Williams T. Williams	521	9,791	521	1	2,292	7,706	1,798	2,654	525	71	1,839	2,021	39	24	4	4,884	1,117	5	20	86	197	.344	.482	.634	1.116	2349	1,219.7	.493	188	1,067
2	Gary Gaetti G. Gaetti	360	9,817	360	1	2,507	8,951	1,130	2,280	443	39	1,341	634	96	96	65	3,881	842	32	104	57	236	.255	.308	.434	.741	1161	12.7	.325	95	-58
3	Anthony Rizzo A. Rizzo	303	7,336	303	1	1,727	6,288	922	1,644	338	22	965	781	222	72	44	2,935	663	0	45	75	149	.261	.361	.467	.828	1103	246.1	.356	125	223.8
4	Adam LaRoche A. LaRoche	255	6,329	255	1	1,605	5,593	752	1,452	340	13	882	649	24	13	11	2,583	608	5	58	67	128	.260	.336	.462	.798	848	107.4	.343	110	77.4
5	Todd Zeile T. Zeile	253	8,649	253	1	2,158	7,573	986	2,004	397	23	1,110	945	42	53	51	3,206	673	8	81	47	223	.265	.346	.423	.769	1128	72.5	.339	104	46.1
6	Nick Swisher N. Swisher	245	6,308	245	1	1,527	5,369	805	1,338	307	11	803	817	56	13	15	2,402	563	13	53	42	131	.249	.351	.447	.799	874	135.5	.348	114	108.7
7	Todd Frazier T. Frazier	218	4,949	218	1	1,244	4,392	604	1,059	212	15	640	438	77	73	38	1,955	445	4	38	12	95	.241	.318	.445	.763	627	54.4	.330	107	41.4
8	Rocky Colavito R. Colavito	187	7,559	374	2	1,841	6,503	971	1,730	283	21	1,159	951	29	19	27	3,177	678	16	60	58	182	.266	.359	.489	.848	1180	349.3	.373	132	288.5
9	Yadier Molina Y. Molina	176	8,553	176	1	2,224	7,817	777	2,168	408	7	1,022	542	76	71	37	3,118	591	43	75	50	287	.277	.327	.399	.726	979	-27.6	.316	97	-39.1
10	Jonathan Schoop J. Schoop	174	4,615	174	1	1,188	4,319	557	1,095	218	7	544	195	61	15	4	1,849	399	7	33	4	127	.254	.293	.428	.721	521	-24.1	.309	93	-33.4
11	Ben Zobrist B. Zobrist	167	6,836	167	1	1,651	5,880	884	1,566	349	44	768	832	31	116	49	2,504	560	26	67	35	124	.266	.357	.426	.783	920	131.5	.342	116	125.7
12	Jonny Gomes J. Gomes	162	4,009	162	1	1,203	3,456	495	835	157	14	526	417	83	50	24	1,506	333	2	51	19	52	.242	.333	.436	.769	512	43.9	.335	106	30
13	Jeff Francoeur J. Francoeur	160	5,660	160	1	1,480	5,260	626	1,373	281	27	698	284	60	54	39	2,188	468	2	54	48	126	.261	.303	.416	.719	605	-63.1	.310	88	-84.7
14	Paul O'Neill P. O'Neill	140.5	8,329	281	2	2,053	7,318	1,041	2,105	451	21	1,269	892	22	141	73	3,441	753	7	90	107	221	.288	.363	.470	.833	1243	238.4	.362	120	212.6
15	Enrique Hernández E. Hernández	130	4,152	130	1	1,275	3,719	515	877	200	15	470	358	27	17	6	1,497	345	8	40	12	80	.236	.305	.403	.707	460	-34.7	.305	91	-44.6
16	David Peralta D. Peralta	125	4,590	125	1	1,232	4,188	526	1,166	238	48	569	336	34	39	16	1,875	411	1	31	20	81	.278	.335	.448	.782	618	75.3	.336	109	47.6
17	Rowdy Tellez R. Tellez	122	2,617	122	1	776	2,362	278	552	108	3	368	210	22	5	3	1,032	233	0	23	19	68	.234	.300	.437	.736	311	-1.7	.314	98	-7.2
18	Jedd Gyorko J. Gyorko	121	2,983	121	1	846	2,693	317	659	111	5	370	248	18	14	6	1,143	237	0	24	6	77	.245	.310	.424	.735	350	6.5	.318	101	6
19	Jeff Cirillo J. Cirillo	112	6,136	112	1	1,617	5,396	800	1,598	343	21	727	563	67	63	37	2,319	476	51	59	18	153	.296	.366	.430	.796	866	95.5	.351	103	29.5
20	Jim Morrison J. Morrison	112	3,695	112	1	1,089	3,375	371	876	170	16	435	213	25	50	37	1,414	298	43	39	15	77	.260	.305	.419	.724	421	1.4	.320	97	-11.5
21	Dave Kingman D. Kingman	110.5	7,429	442	4	1,941	6,677	901	1,575	240	25	1,210	608	53	85	49	3,191	707	16	75	72	139	.236	.302	.478	.780	960	139.8	.343	113	108.5
22	Jackie Bradley Jr. J. Bradley Jr.	109	4,192	109	1	1,181	3,735	514	839	204	27	449	361	66	69	18	1,424	340	8	22	17	64	.225	.303	.381	.684	434	-62.1	.297	82	-91.9
23	Franmil Reyes F. Reyes	108	2,078	108	1	548	1,881	237	468	73	4	285	172	5	6	2	873	185	0	20	4	54	.249	.310	.464	.775	273	22.4	.328	108	22.9
24	Alex Avila A. Avila	105	3,638	105	1	1,052	3,060	352	714	155	9	397	528	19	8	8	1,202	269	11	20	24	83	.233	.348	.393	.740	453	34.8	.328	104	16.9
25	David Murphy D. Murphy	104	3,836	104	1	1,110	3,467	440	950	203	16	472	316	9	54	28	1,497	323	7	37	23	61	.274	.333	.432	.765	481	43	.333	102	10.5