Babe Ruth has the highest career on-base percentage with 8,000+ at-bats, with an on-base percentage of .474.

Interpreted as:

highest career obp by a player with 8000+ at bats

	NAME	OBP	AB	G	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	SLG	OPS	wRC	WRAA	wOBA	wRC+	BRAA
1	Babe Ruth B. Ruth	.474	8,399	2,503	2,174	2,873	506	136	714	2,214	2,062	43	1,330	123		10,617	5,793	1,356	113				.342	.690	1.164	2727	1,436.8	.513	197	1,369.6
2	Lou Gehrig L. Gehrig	.447	8,001	2,164	1,888	2,721	534	163	493	1,995	1,508	45	790	102		9,660	5,060	1,190	106			2	.340	.632	1.080	2265	1,046.8	.477	173	980
3	Barry Bonds B. Bonds	.444	9,847	2,986	2,227	2,935	601	77	762	1,996	2,558	106	1,539	514	141	12,606	5,976	1,440	4	91	688	165	.298	.607	1.051	2663	1,143.3	.435	172	1,142
4	Rogers Hornsby R. Hornsby	.434	8,173	2,259	1,579	2,930	541	169	301	1,584	1,038	48	679	135		9,475	4,712	1,011	216				.358	.577	1.010	2018	899	.459	173	863.2
5	Ty Cobb T. Cobb	.433	11,434	3,034	2,244	4,189	724	295	117	1,933	1,249	94	681	897		13,068	5,854	1,136	291				.366	.512	.945	2534	1,093.6	.445	165	975.1
6	Jimmie Foxx J. Foxx	.428	8,134	2,317	1,751	2,646	458	125	534	1,922	1,452	13	1,311	87		9,670	4,956	1,117	71			69	.325	.609	1.038	2135	934.1	.460	158	780.8
7	Tristram Speaker T. Speaker	.428	10,195	2,789	1,882	3,514	792	222	117	1,531	1,381	103	394	436		11,988	5,101	1,131	309				.345	.500	.928	2264	921	.436	157	812.3
8	Eddie Collins E. Collins	.424	9,949	2,826	1,821	3,315	438	187	47	1,300	1,499	77	468	741		12,037	4,268	672	512				.333	.429	.853	2032	693.4	.409	144	619.7
9	Mickey Mantle M. Mantle	.421	8,102	2,401	1,676	2,415	344	72	536	1,509	1,733	13	1,710	153	38	9,909	4,511	952	14	47	126	113	.298	.557	.977	1941	840	.428	170	821.8
10	Frank Thomas F. Thomas	.419	8,199	2,322	1,494	2,468	495	12	521	1,704	1,667	87	1,397	32	23	10,074	4,550	1,028	0	121	168	226	.301	.555	.974	1954	721.1	.416	154	692
11	Stan Musial S. Musial	.417	10,972	3,026	1,949	3,630	725	177	475	1,951	1,599	53	696	78	31	12,712	6,134	1,377	35	53	127	243	.331	.559	.976	2474	1,032.5	.435	158	896.7
12	Wade Boggs W. Boggs	.415	9,180	2,439	1,513	3,010	578	61	118	1,014	1,412	23	745	24	35	10,740	4,064	757	29	96	180	236	.328	.443	.858	1746	493.9	.381	132	411
13	Jesse Burkett J. Burkett	.415	8,426	2,067	1,720	2,850	320	182	75	952	1,029	75	561	389		9,620	3,759	577	90				.338	.446	.861	1921	592.9	.411	137	526.7
14	Mel Ott M. Ott	.414	9,456	2,730	1,859	2,876	488	72	511	1,860	1,708	64	896	89		11,337	5,041	1,071	109			38	.304	.533	.947	2204	826.4	.430	156	794.2
15	Manny Ramirez M. Ramirez	.411	8,244	2,302	1,544	2,574	547	20	555	1,831	1,329	109	1,813	38	33	9,774	4,826	1,122	2	90	216	243	.312	.585	.996	1931	719.5	.418	153	658.7
16	Paul Waner P. Waner	.404	9,459	2,549	1,627	3,152	605	191	113	1,309	1,091	38	376	104		10,762	4,478	909	174			45	.333	.473	.878	1868	537	.403	135	487.9
17	Charlie Gehringer C. Gehringer	.404	8,860	2,323	1,775	2,839	574	146	184	1,427	1,186	50	372	181		10,237	4,257	904	141			27	.320	.480	.884	1797	516.6	.405	124	350
18	Jim Thome J. Thome	.402	8,422	2,543	1,583	2,328	451	26	612	1,699	1,747	69	2,548	19	20	10,313	4,667	1,089	1	74	173	165	.276	.554	.956	1925	653.9	.406	145	589.5
19	Rickey Henderson R. Henderson	.401	10,961	3,081	2,295	3,055	510	66	297	1,115	2,190	98	1,694	1,406	335	13,346	4,588	873	30	67	61	172	.279	.419	.820	2074	509.6	.372	132	507.9
20	Chipper Jones C. Jones	.401	8,984	2,499	1,619	2,726	549	38	468	1,623	1,512	18	1,409	150	46	10,614	4,755	1,055	3	97	177	253	.303	.529	.930	1904	598.1	.397	141	563
21	Luke Appling L. Appling	.399	8,856	2,422	1,319	2,749	440	102	45	1,116	1,302	11	528	179		10,243	3,528	587	74			129	.310	.398	.798	1538	325.1	.378	115	198.1
22	Richie Ashburn R. Ashburn	.396	8,365	2,189	1,322	2,574	317	109	29	586	1,198	43	571	234	92	9,736	3,196	455	112	18	25	83	.308	.382	.778	1374	247.3	.362	115	179.4
23	Cap Anson C. Anson	.396	9,104	2,277	1,722	3,012	529	124	97	1,306	953	32	146	247		10,123	4,080	750	34				.331	.448	.844	2154	654.1	.397	134	525.3
24	Bobby Abreu B. Abreu	.395	8,480	2,425	1,453	2,470	574	59	288	1,363	1,476	33	1,840	400	128	10,081	4,026	921	7	85	115	165	.291	.475	.870	1648	417.8	.378	129	382
25	Gary Sheffield G. Sheffield	.393	9,217	2,576	1,636	2,689	467	27	509	1,676	1,475	135	1,171	253	104	10,947	4,737	1,003	9	111	130	235	.292	.514	.907	1907	574.5	.391	141	567.2