Since 1954, Barry Bonds has the most runs per at-bat with 500+ at-bats, with 0.23.

Interpreted as:

highest runs/ab by a player since 1954 min 500 ab

	NAME	R/AB	AB	R	G	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Barry Bonds B. Bonds	0.23	9,847	2,227	2,986	2,935	601	77	762	1,996	2,558	106	1,539	514	141	12,606	5,976	1,440	4	91	688	165	.298	.444	.607	1.051	2663	1,143.3	.435	172	1,142
2	Larry Lintz L. Lintz	0.22	616	137	350	140	13	1	0	27	97	4	101	128	38	756	155	14	39	0	1	5	.227	.336	.252	.588	65	-17.7	.288	72	-24.5
3	Aaron Judge A. Judge	0.21	4,105	873	1,145	1,205	203	7	368	830	817	40	1,369	65	21	4,995	2,526	578	0	33	104	116	.294	.413	.615	1.028	1050	453.4	.425	178	457.2
4	Mickey Mantle M. Mantle	0.21	6,751	1,416	2,036	2,017	272	57	479	1,265	1,536	13	1,435	133	26	8,357	3,840	808	10	47	126	103	.299	.427	.569	.996	1681	758.4	.433	175	740
5	Rickey Henderson R. Henderson	0.21	10,961	2,295	3,081	3,055	510	66	297	1,115	2,190	98	1,694	1,406	335	13,346	4,588	873	30	67	61	172	.279	.401	.419	.820	2074	509.6	.372	132	507.9
6	Ronald Acuña Jr. R. Acuña Jr.	0.21	3,156	655	817	913	157	13	186	459	439	53	821	205	50	3,663	1,654	356	0	15	21	47	.289	.384	.524	.908	654	213.7	.386	143	194.7
7	Juan Soto J. Soto	0.2	3,857	775	1,096	1,086	199	16	244	697	896	19	833	95	27	4,801	2,049	459	3	26	80	101	.282	.417	.531	.948	919	344.3	.402	158	338.1
8	Ted Williams T. Williams	0.2	2,519	506	828	850	153	9	184	541	673	18	255	4	2	3,230	1,573	346	0	20	86	75	.337	.477	.624	1.102	748	380.8	.474	187	336.3
9	Mike Trout M. Trout	0.2	5,966	1,196	1,648	1,754	325	55	404	1,018	1,067	106	1,662	214	38	7,200	3,401	784	0	61	130	75	.294	.407	.570	.977	1392	555.5	.410	166	556.8
10	Larry Walker L. Walker	0.2	6,907	1,355	1,988	2,160	471	62	383	1,311	913	138	1,231	230	76	8,030	3,904	916	7	65	117	153	.313	.400	.565	.965	1532	556.6	.412	140	406.2
11	Corbin Carroll C. Carroll	0.2	1,822	357	488	470	93	43	82	248	205	33	439	122	20	2,086	895	218	9	17	5	17	.258	.341	.491	.832	318	70.7	.355	126	64.8
12	Jeff Bagwell J. Bagwell	0.19	7,797	1,517	2,150	2,314	488	32	449	1,529	1,401	128	1,558	202	78	9,431	4,213	969	3	102	155	221	.297	.408	.540	.948	1755	596.6	.405	149	588.3
13	Willie Mays W. Mays	0.19	10,290	1,986	2,837	3,126	499	131	636	1,812	1,391	41	1,449	327	98	11,825	5,795	1,266	12	91	192	238	.304	.386	.563	.949	2170	876.4	.411	156	789.4
14	Mookie Betts M. Betts	0.19	6,083	1,166	1,531	1,767	394	41	291	913	736	52	924	196	41	6,936	3,116	726	4	61	35	86	.290	.369	.512	.881	1158	334.4	.374	136	307
15	Alex Rodriguez A. Rodriguez	0.19	10,566	2,021	2,784	3,115	548	31	696	2,086	1,338	176	2,287	329	76	12,207	5,813	1,275	16	111	97	261	.295	.380	.550	.930	2178	690.1	.395	141	629.5
16	Shohei Ohtani S. Ohtani	0.19	3,730	708	1,018	1,050	192	45	280	669	541	25	1,104	165	43	4,316	2,172	517	0	20	88	49	.282	.374	.582	.957	807	292.3	.397	156	288.6
17	Mark McGwire M. McGwire	0.19	6,187	1,167	1,874	1,626	252	6	583	1,414	1,317	75	1,596	12	8	7,660	3,639	841	3	78	150	147	.263	.394	.588	.982	1480	564.9	.415	157	558.2
18	Tim Locastro T. Locastro	0.19	531	100	290	121	25	3	9	38	36	43	125	45	5	616	179	37	4	2	0	3	.228	.327	.337	.664	67	-9.2	.299	85	-11.8
19	Kenny Lofton K. Lofton	0.19	8,120	1,528	2,103	2,428	383	116	130	781	945	32	1,016	622	160	9,234	3,433	629	72	65	43	111	.299	.372	.423	.794	1303	163.2	.352	109	111.9
20	Jim Thome J. Thome	0.19	8,422	1,583	2,543	2,328	451	26	612	1,699	1,747	69	2,548	19	20	10,313	4,667	1,089	1	74	173	165	.276	.402	.554	.956	1925	653.9	.406	145	589.5
21	Manny Ramirez M. Ramirez	0.19	8,244	1,544	2,302	2,574	547	20	555	1,831	1,329	109	1,813	38	33	9,774	4,826	1,122	2	90	216	243	.312	.411	.585	.996	1931	719.5	.418	153	658.7
22	Jon Nunnally J. Nunnally	0.18	885	162	364	218	47	12	42	125	146	5	239	19	12	1,048	415	101	6	6	10	11	.246	.354	.469	.823	152	20.6	.357	111	14.1
23	Fernando Tatis Jr. F. Tatis Jr.	0.18	2,603	476	671	721	136	12	152	393	293	28	690	124	27	2,939	1,337	300	1	14	15	46	.277	.355	.514	.868	484	128.3	.368	137	135.1
24	Frank Robinson F. Robinson	0.18	10,006	1,829	2,808	2,943	528	72	586	1,812	1,420	198	1,532	204	77	11,743	5,373	1,186	17	102	218	270	.294	.389	.537	.926	2083	807.2	.404	153	717.1
25	J.D. Drew	0.18	5,173	944	1,566	1,437	273	48	242	795	862	55	1,137	87	37	6,153	2,532	563	19	44	52	84	.278	.384	.489	.873	1004	250.1	.378	128	217.7