Lou Gehrig has the most RBIs + runs in a season, with 348 in 1931.

Interpreted as:

highest single season rbi + runs by a player

	NAME	RBI+R	RBI	R	SEASON	TM	G	AB	H	2B	3B	HR	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Lou Gehrig L. Gehrig	348	185	163	1931	NYY	155	619	211	31	15	46	117	0	56	17	12	738	410	92	2				.341	.446	.662	1.108	179	87.7	.488	184	83.8
2	Babe Ruth B. Ruth	345	168	177	1921	NYY	152	540	204	44	16	59	145	4	81	17	13	693	457	119	4				.378	.512	.846	1.359	214	127.8	.575	224	118.7
3	Hack Wilson H. Wilson	337	191	146	1930	CHC	155	585	208	35	6	56	105	1	84	3		709	423	97	18				.356	.454	.723	1.177	189	89	.497	171	78.9
4	Chuck Klein C. Klein	328	170	158	1930	PHN	156	648	250	59	8	40	54	4	50	4		719	445	107	13				.386	.436	.687	1.123	181	80	.481	152	58.7
5	Babe Ruth B. Ruth	323	165	158	1927	NYY	151	540	192	29	8	60	137	0	89	7	6	691	417	97	14				.356	.486	.772	1.258	195	109.9	.545	212	104.8
6	Lou Gehrig L. Gehrig	322	173	149	1927	NYY	155	584	218	52	18	47	109	3	84	10	8	717	447	117	21				.373	.474	.765	1.240	199	110.9	.540	209	105.6
7	Hank Greenberg H. Greenberg	321	184	137	1937	DET	154	594	200	49	14	40	102	3	101	8	3	701	397	103	2				.337	.436	.668	1.105	167	79.5	.483	164	65.3
8	Jimmie Foxx J. Foxx	320	169	151	1932	PHA	154	585	213	33	9	58	116	0	96	3	7	701	438	100	0				.364	.469	.749	1.218	193	105.6	.522	198	95.8
9	Lou Gehrig L. Gehrig	319	152	167	1936	NYY	155	579	205	37	7	49	130	7	46	3	4	719	403	93	3				.354	.478	.696	1.174	192	97.6	.512	178	85.8
10	Joe DiMaggio J. DiMaggio	318	167	151	1937	NYY	151	621	215	35	15	46	64	5	37	3	0	692	418	96	2				.346	.412	.673	1.085	160	73.6	.474	165	64.8
11	Al Simmons A. Simmons	317	165	152	1930	PHA	138	554	211	41	16	36	39	1	34	9	2	611	392	93	17				.381	.423	.708	1.130	153	67.4	.480	173	63.8
12	Lou Gehrig L. Gehrig	316	173	143	1930	NYY	154	581	220	42	17	41	101	3	63	12	14	703	419	100	18				.379	.473	.721	1.194	193	94.5	.507	198	98.3
13	Jimmie Foxx J. Foxx	314	175	139	1938	BSA	149	565	197	33	9	50	119	0	76	5	4	685	398	92	1				.349	.462	.704	1.166	178	91.7	.508	173	74.2
14	Babe Ruth B. Ruth	311	162	149	1931	NYY	145	534	199	31	3	46	128	1	51	5	4	663	374	80	0				.373	.495	.700	1.195	181	98.6	.525	206	95.1
15	Ted Williams T. Williams	309	159	150	1949	BSA	155	566	194	39	3	43	162	2	48	1	1	730	368	85	0			22	.343	.490	.650	1.141	182	95.5	.511	187	82.2
16	Babe Ruth B. Ruth	309	146	163	1928	NYY	154	536	173	29	8	54	137	3	87	4	5	684	380	91	8				.323	.463	.709	1.172	174	90.6	.510	201	89.3
17	Sammy Sosa S. Sosa	306	160	146	2001	CHC	160	577	189	34	5	64	116	6	153	0	2	711	425	103	0	12	37	6	.328	.437	.737	1.174	171	82.7	.465	186	79.8
18	Rogers Hornsby R. Hornsby	305	149	156	1929	CHC	156	602	229	47	8	39	87	1	65	2		712	409	94	22				.380	.459	.679	1.139	181	86.8	.497	174	77.3
19	Hugh Duffy H. Duffy	305	145	160	1894	BSN	125	539	237	51	16	18	66	1	15	48		616	374	85	10				.440	.502	.694	1.196	203	91.3	.526	169	80.7
20	Babe Ruth B. Ruth	303	153	150	1930	NYY	145	518	186	28	9	49	136	1	61	10	10	676	379	86	21				.359	.493	.732	1.225	192	97	.517	204	100.6
21	Alex Rodriguez A. Rodriguez	299	156	143	2007	NYY	158	583	183	31	0	54	95	21	120	24	4	708	376	85	0	9	11	15	.314	.422	.645	1.067	155	67.5	.445	175	66.2
22	Manny Ramirez M. Ramirez	296	165	131	1999	CLE	147	522	174	34	3	44	96	13	131	2	4	640	346	81	0	9	9	12	.333	.442	.663	1.105	149	65.7	.459	172	61.8
23	Lou Gehrig L. Gehrig	296	158	138	1937	NYY	157	569	200	37	9	37	127	4	49	4	3	700	366	83	0				.351	.473	.643	1.116	173	85.5	.494	176	76.5
24	Sam Thompson S. Thompson	296	165	131	1895	PHI	119	538	211	45	21	18	31	5	11	27		576	352	84	2				.392	.430	.654	1.085	158	62.8	.480	162	60.9
25	Al Simmons A. Simmons	295	151	144	1932	PHA	154	670	216	28	9	35	47	1	76	4	2	718	367	72	0				.322	.368	.548	.915	130	39.9	.405	130	29.9