5 players are tied for the most home runs in a game on September 16, with 3 home runs. The first three are Dominic Canzone on September 16, Yordan Alvarez on September 16, 2022 and Kyle Higashioka on September 16, 2020.
| NAME | HR | DATE | TM | OPP | AB | R | H | 2B | 3B | RBI | BB | HBP | SO | SB | CS | PA | TB | XBH | SH | SF | IBB | GIDP | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | D. Canzone | 3 | 9/16/2025 |  SEA | @ |  KCR | 5 | 4 | 5 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 5 | 14 | 3 | 0 | 0 | 0 | 0 |
| 2 |  | Y. Alvarez | 3 | 9/16/2022 |  HOU | vs |  OAK | 4 | 3 | 4 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 4 | 13 | 3 | 0 | 0 | 0 | 0 |
| 3 | | K. Higashioka | 3 | 9/16/2020 |  NYY | vs |  TOR | 4 | 3 | 3 | 0 | 0 | 5 | 0 | 0 | 0 | 0 | 0 | 4 | 12 | 3 | 0 | 0 | 0 | 0 |
| 4 | | A. Ramirez | 3 | 9/16/2004 |  CHC | @ |  CIN | 5 | 3 | 4 | 1 | 0 | 5 | 0 | 0 | 0 | 0 | 0 | 5 | 14 | 4 | 0 | 0 | 0 | 0 |
| 5 | | R. Hidalgo | 3 | 9/16/2003 |  HOU | @ |  COL | 4 | 4 | 3 | 0 | 0 | 5 | 1 | 0 | 1 | 0 | 0 | 5 | 12 | 3 | 0 | 0 | 0 | 0 |
| 6 |  | C. Raleigh | 2 | 9/16/2025 | SEA | @ | KCR | 5 | 3 | 3 | 1 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 5 | 10 | 3 | 0 | 0 | 0 | 0 |
| 7 | | C. Jensen | 2 | 9/16/2025 | KCR | vs | SEA | 4 | 3 | 3 | 1 | 0 | 3 | 0 | 0 | 1 | 0 | 0 | 4 | 10 | 3 | 0 | 0 | 0 | 0 |
| 8 |  | A. Benintendi | 2 | 9/16/2024 |  CWS | @ |  LAA | 3 | 2 | 2 | 0 | 0 | 4 | 2 | 0 | 0 | 0 | 0 | 5 | 8 | 2 | 0 | 0 | 0 | 0 |
| 9 |  | M. Chapman | 2 | 9/16/2022 | TOR | vs |  BAL | 4 | 3 | 3 | 0 | 0 | 3 | 0 | 0 | 1 | 0 | 0 | 4 | 9 | 2 | 0 | 0 | 0 | 0 |
| 10 | | B. Drury | 2 | 9/16/2022 |  SDP | @ |  ARI | 5 | 2 | 2 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 5 | 8 | 2 | 0 | 0 | 0 | 0 |
| 11 |  | C. Walker | 2 | 9/16/2022 | ARI | vs | SDP | 4 | 2 | 2 | 0 | 0 | 3 | 0 | 0 | 1 | 0 | 0 | 4 | 8 | 2 | 0 | 0 | 0 | 0 |
| 12 | | L. Rengifo | 2 | 9/16/2022 | LAA | vs | SEA | 5 | 3 | 3 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 5 | 9 | 2 | 0 | 0 | 0 | 0 |
| 13 |  | C. Santana | 2 | 9/16/2022 | SEA | @ | LAA | 4 | 2 | 2 | 0 | 0 | 3 | 1 | 0 | 1 | 0 | 0 | 5 | 8 | 2 | 0 | 0 | 0 | 0 |
| 14 | | J. Alfaro | 2 | 9/16/2020 |  MIA | vs |  BOS | 3 | 2 | 2 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 3 | 8 | 2 | 0 | 0 | 0 | 0 |
| 15 |  | DJ LeMahieu | 2 | 9/16/2020 | NYY | vs | TOR | 4 | 3 | 3 | 1 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 5 | 10 | 3 | 0 | 0 | 0 | 0 |
| 16 | | D. Palka | 2 | 9/16/2018 | CWS | @ | BAL | 4 | 2 | 2 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 0 | 4 | 8 | 2 | 0 | 0 | 0 | 0 |
| 17 |  | J. Donaldson | 2 | 9/16/2017 | TOR | @ |  MIN | 5 | 4 | 4 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 5 | 10 | 2 | 0 | 0 | 0 | 0 |
| 18 |  | J. Upton | 2 | 9/16/2017 | LAA | vs |  TEX | 3 | 2 | 2 | 0 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 4 | 8 | 2 | 0 | 0 | 0 | 1 |
| 19 |  | J. Upton | 2 | 9/16/2016 |  DET | @ |  CLE | 3 | 2 | 2 | 0 | 0 | 4 | 1 | 0 | 1 | 0 | 0 | 4 | 8 | 2 | 0 | 0 | 0 | 0 |
| 20 |  | D. Pedroia | 2 | 9/16/2015 | BOS | @ | BAL | 4 | 2 | 2 | 0 | 0 | 5 | 1 | 0 | 0 | 0 | 0 | 5 | 8 | 2 | 0 | 0 | 0 | 0 |
| 21 | | P. Fielder | 2 | 9/16/2015 | TEX | vs | HOU | 5 | 3 | 3 | 0 | 0 | 5 | 0 | 0 | 1 | 0 | 0 | 5 | 9 | 2 | 0 | 0 | 0 | 0 |
| 22 |  | T. Pham | 2 | 9/16/2015 |  STL | @ |  MIL | 4 | 2 | 3 | 0 | 1 | 4 | 0 | 0 | 0 | 0 | 0 | 4 | 11 | 3 | 0 | 0 | 0 | 0 |
| 23 | | J. Werth | 2 | 9/16/2015 |  WSH | @ |  PHI | 4 | 3 | 3 | 0 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 5 | 9 | 2 | 0 | 0 | 0 | 0 |
| 24 |  | W. Flores | 2 | 9/16/2014 |  NYM | vs |  MIA | 4 | 3 | 3 | 1 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 4 | 10 | 3 | 0 | 0 | 0 | 0 |
| 25 | | M. Wieters | 2 | 9/16/2012 | BAL | @ | OAK | 3 | 3 | 2 | 0 | 0 | 2 | 2 | 0 | 1 | 0 | 0 | 5 | 8 | 2 | 0 | 0 | 1 | 0 |
Results may be incomplete. StatMuse has complete game-level data for home runs going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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