Answered January 12th, 2020

Since 1930, Lefty Mills has the highest 2 * runs allowed * strikeouts in a game, with 220 against the Yankees on August 24, 1939.

most 2*r*so/(r so) in a game by a pitcher since 1930
Interpreted as:
most 2*r*so/(r so) in a regular-season game by a pitcher since 1930

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