Between the 2000 and 2009 seasons, Randy Johnson played the most seasons with 300+ strikeouts, with 3 seasons.
| NAME | SEAS | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | ERA- | FIP | FIP- | H/9 | PRAA | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Johnson | 3 | 1,053 | 105 | 64 | 18 | .780 | 104 | 2.48 | 19 | 9 | 0 | 758.1 | 580 | 209 | 241 | 68 | 218 | 37 | 1 | 4 | 3,030 | 16 | 12.50 | 2.59 | 4.83 | 0.81 | 34.8 | 7.2 | 1.05 | .310 | 2.86 | 55 | 2.44 | 54 | 6.88 | 171.9 |
| 2 |  | C. Schilling | 1 | 316 | 36 | 23 | 7 | .767 | 35 | 3.23 | 5 | 1 | 0 | 259.1 | 218 | 93 | 95 | 29 | 33 | 3 | 0 | 1 | 1,017 | 6 | 10.97 | 1.15 | 9.58 | 1.01 | 31.1 | 3.2 | 0.97 | .297 | 3.30 | 75 | 2.39 | 55 | 7.57 | 54.3 |
Dodgers 
Padres 
Giants 
Diamondbacks 
Rockies 
Phillies 
Mets 
Brewers 
Cubs 
Blue Jays 
Yankees 
Guardians 
Tigers 
Mariners 
Astros 
ATL 
WSH 
TBR 
BAL 
CWS 
MIN 
CIN 
STL 
