Nolan Ryan had the most games pitched when striking out 7+ batters, with 447 games.

Interpreted as:

most 7+ strikeout regular-season games by a pitcher

	NAME	G	SO	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Nolan Ryan N. Ryan	447	4,381	237	133	.641	445	2.27	189	56	0	3517.0	2,215	887	1,022	171	1,620	87	1	46	14,229	164	11.21	4.15	2.70	0.44	30.8	11.4	1.09	.256	2.62	5.67
2	Randy Johnson R. Johnson	398	4,018	232	80	.744	396	2.46	94	37	1	2954.0	2,085	809	898	259	937	124	2	24	11,759	58	12.24	2.85	4.29	0.79	34.2	8.0	1.02	.284	2.74	6.35
3	Roger Clemens R. Clemens	350	3,163	205	67	.754	350	2.32	86	32	0	2637.2	1,954	679	745	166	746	70	0	28	10,490	64	10.79	2.55	4.24	0.57	30.2	7.1	1.02	.282	2.54	6.67
4	Max Scherzer M. Scherzer	287	2,631	159	54	.746	286	2.55	12	5	0	1923.1	1,374	544	578	211	439	65	0	16	7,528	41	12.31	2.05	5.99	0.99	34.9	5.8	0.94	.278	2.70	6.43
5	Steve Carlton S. Carlton	258	2,364	169	57	.748	258	2.36	143	28	0	2134.0	1,652	560	618	127	666	17	0	52	8,559	77	9.97	2.81	3.55	0.54	27.6	7.8	1.09	.283	2.61	6.97
6	Justin Verlander J. Verlander	255	2,242	156	45	.776	255	2.28	18	8	0	1764.0	1,224	446	485	160	382	51	0	9	6,853	49	11.44	1.95	5.87	0.82	32.7	5.6	0.91	.265	2.47	6.24
7	Clayton Kershaw C. Kershaw	232	2,069	145	40	.784	232	1.89	20	13	0	1615.2	1,073	339	371	111	319	25	0	8	6,162	54	11.53	1.78	6.49	0.62	33.6	5.2	0.86	.264	2.07	5.98
8	Pedro Martinez P. Martinez	231	2,241	133	47	.739	231	2.02	40	16	0	1699.1	1,145	382	427	105	398	73	0	14	6,610	37	11.87	2.11	5.63	0.56	33.9	6.0	0.91	.274	2.26	6.06
9	Tom Seaver T. Seaver	231	2,069	149	48	.756	231	2.03	124	33	0	1916.0	1,344	433	460	132	483	26	0	35	7,469	37	9.72	2.27	4.28	0.62	27.7	6.5	0.95	.255	2.16	6.31
10	Bert Blyleven B. Blyleven	225	1,921	128	55	.699	225	2.15	125	31	0	1857.2	1,422	443	502	116	455	47	0	17	7,344	35	9.31	2.20	4.22	0.56	26.2	6.2	1.01	.272	2.43	6.89
11	Curt Schilling C. Schilling	220	2,049	125	55	.694	220	2.69	52	14	0	1652.1	1,356	494	516	149	292	26	0	15	6,517	36	11.16	1.59	7.02	0.81	31.4	4.5	1.00	.302	2.81	7.39
12	Bob Gibson B. Gibson	215	1,945	143	56	.719	215	2.11	160	33	0	1889.0	1,430	443	511	94	545	46	0	42	7,568	42	9.27	2.60	3.57	0.45	25.7	7.2	1.05	.271	2.43	6.81
13	Chris Sale C. Sale	202	1,913	104	44	.703	202	2.43	13	3	0	1358.1	991	366	399	121	290	79	0	6	5,352	28	12.68	1.92	6.60	0.80	35.7	5.4	0.94	.295	2.64	6.57
14	John Smoltz J. Smoltz	188	1,589	105	41	.719	188	2.43	33	12	0	1383.1	1,045	374	411	106	358	22	0	29	5,480	55	10.34	2.33	4.44	0.69	29.0	6.5	1.01	.276	2.67	6.80
15	CC Sabathia	183	1,552	113	31	.785	183	2.37	26	11	0	1297.2	1,017	341	382	99	319	40	0	12	5,158	22	10.76	2.21	4.87	0.69	30.1	6.2	1.03	.292	2.65	7.05
16	Walter Johnson W. Johnson	181	1,555	127	48	.726	177	0.73	169	51	0	1662.2	1,113		349	14	339	59	4		6,391	62	8.42	1.84	4.59	0.08	24.3	5.3	0.87	.248	1.89	6.02
17	Gerrit Cole G. Cole	180	1,636	101	32	.759	180	2.58	5	4	0	1153.0	838	331	362	122	262	29	0	1	4,504	35	12.77	2.05	6.24	0.95	36.3	5.8	0.95	.292	2.83	6.54
18	Don Sutton D. Sutton	180	1,481	102	44	.699	180	2.10	83	26	0	1467.1	1,054	342	382	96	340	17	0	24	5,755	29	9.08	2.09	4.36	0.59	25.7	5.9	0.95	.251	2.34	6.46
19	David Cone D. Cone	179	1,605	105	41	.719	179	2.28	36	13	0	1346.0	974	341	388	101	435	37	0	16	5,411	66	10.73	2.91	3.69	0.68	29.7	8.0	1.05	.270	2.59	6.51
20	Sandy Koufax S. Koufax	179	1,782	124	34	.785	178	1.85	114	29	0	1509.1	973	311	352	101	434	7	1	29	5,904	52	10.63	2.59	4.11	0.60	30.2	7.4	0.93	.244	2.10	5.80
21	Cole Hamels C. Hamels	178	1,492	90	34	.726	178	2.40	7	2	0	1239.1	934	331	360	122	300	40	0	21	4,896	19	10.83	2.18	4.97	0.89	30.5	6.1	1.00	.276	2.61	6.78
22	Fergie Jenkins F. Jenkins	176	1,514	121	44	.733	173	2.21	128	25	0	1506.1	1,118	370	410	136	269	30	2	31	5,879	23	9.05	1.61	5.63	0.81	25.8	4.6	0.92	.250	2.45	6.68
23	Gaylord Perry G. Perry	176	1,527	106	45	.702	174	2.05	112	18	0	1548.2	1,172	353	410	99	359	31	0	38	6,105	37	8.87	2.09	4.25	0.58	25.0	5.9	0.99	.262	2.38	6.81
24	Sam McDowell S. McDowell	176	1,674	96	38	.716	176	2.07	82	20	0	1413.2	948	325	385	73	626	33	1	33	5,752	62	10.66	3.99	2.67	0.46	29.1	10.9	1.11	.262	2.45	6.04
25	Zack Greinke Z. Greinke	173	1,449	100	27	.787	173	2.28	7	3	0	1183.0	903	300	321	90	211	19	0	4	4,588	31	11.02	1.61	6.87	0.68	31.6	4.6	0.94	.288	2.44	6.87