Lou Gehrig has the most games with 2+ runs in a season, with 52 games in 1931.

Interpreted as:

most games by a player with 2+ runs in one season

	NAME	G	R	SEASON	TM	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Lou Gehrig L. Gehrig	52	113	1931	NYY	215	109	15	9	30	98	56	0	15	12		271	232	54	0				.507	.609	1.079	1.688
2	Babe Ruth B. Ruth	51	114	1921	NYY	180	96	17	10	36	89	57	3	21	8		241	241	63	1				.533	.650	1.339	1.989
3	Babe Ruth B. Ruth	51	114	1920	NYY	165	88	18	5	38	84	67	1	21	11		237	230	61	4				.533	.670	1.394	2.063
4	Lou Gehrig L. Gehrig	45	104	1936	NYY	173	94	16	3	30	83	53	2	6	2		228	206	49	0				.543	.654	1.191	1.844
5	Babe Ruth B. Ruth	45	102	1930	NYY	162	81	7	3	38	82	63	0	9	6		228	208	48	3				.500	.640	1.284	1.924
6	Chuck Klein C. Klein	44	101	1930	PHN	202	105	21	2	27	86	22	2	10	0		229	211	50	3				.520	.571	1.045	1.615
7	Babe Ruth B. Ruth	44	100	1927	NYY	166	84	13	5	35	81	46	0	18	2		214	212	53	2				.506	.613	1.277	1.890
8	Chuck Klein C. Klein	43	94	1932	PHN	188	103	21	9	26	75	20	0	7	8		208	220	56	0				.548	.591	1.170	1.762
9	Larry Walker L. Walker	42	95	1997	COL	168	95	23	1	32	72	27	7	17	16	2	203	216	56	0	1	5	1	.565	.635	1.286	1.921
10	Augie Galan A. Galan	42	92	1935	CHC	187	87	14	5	10	36	40	1	16	10		230	141	29	2				.465	.561	.754	1.315
11	Charlie Gehringer C. Gehringer	42	92	1930	DET	177	92	24	10	10	47	25	4	3	9		206	166	44	0				.520	.587	.938	1.525
12	Jeff Bagwell J. Bagwell	41	90	2000	HOU	149	74	13	0	26	59	39	10	13	5	1	198	165	39	0	0	2	6	.497	.621	1.107	1.729
13	Ted Williams T. Williams	41	91	1949	BSA	160	75	12	1	25	79	53	0	15	1		213	164	38	0			7	.469	.601	1.025	1.626
14	Rogers Hornsby R. Hornsby	41	92	1929	CHC	162	84	16	4	18	57	38	0	20	0		205	162	38	5				.519	.610	1.000	1.610
15	Babe Ruth B. Ruth	41	96	1928	NYY	144	67	8	6	32	66	51	0	18	3		196	183	46	1				.465	.605	1.271	1.876
16	Ty Cobb T. Cobb	41	92	1915	DET	154	79	10	8	1		42	3	2	42		201	108	19	2				.513	.623	.701	1.324
17	Aaron Judge A. Judge	40	89	2025	NYY	144	75	9	0	33	55	42	4	21	6	1	191	183	42	0	1	12	4	.521	.634	1.271	1.904
18	Shohei Ohtani S. Ohtani	40	88	2025	LAD	150	66	8	5	27	44	44	0	40	8	1	195	165	40	0	1	11	1	.440	.564	1.100	1.664
19	Aaron Judge A. Judge	40	85	2022	NYY	157	81	11	0	41	78	33	3	32	3	1	195	215	52	0	2	3	3	.516	.600	1.369	1.969
20	Sammy Sosa S. Sosa	40	92	2001	CHC	144	82	11	3	41	95	42	2	21	0	0	191	222	55	0	3	12	2	.569	.660	1.542	2.201
21	Roberto Alomar R. Alomar	40	83	1999	CLE	149	69	12	3	11	46	39	3	16	21	1	196	120	26	3	2	0	2	.463	.575	.805	1.380
22	Craig Biggio C. Biggio	40	86	1997	HOU	156	74	14	6	11	35	27	14	16	23	4	197	133	31	0	0	2	0	.474	.584	.853	1.436
23	Billy Williams B. Williams	40	88	1970	CHC	162	83	12	2	26	62	31	0	14	2	0	193	177	40	0	0	1	2	.512	.591	1.093	1.683
24	Ted Williams T. Williams	40	88	1941	BSA	143	81	11	1	24	59	47	1	2	0		191	166	36	0			2	.566	.675	1.161	1.836
25	Joe DiMaggio J. DiMaggio	40	93	1937	NYY	174	84	17	4	24	74	20	3	6	1		198	181	45	1				.483	.543	1.040	1.583