Rickey Henderson had the most games when making 5+ plate appearances with exactly 0 hits, with 354 games.

Interpreted as:

most regular-season games by a player with 5+ PA and 0 hits

	NAME	G	PA	H	AB	R	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Rickey Henderson R. Henderson	354	1,799	0	1,319	174	0	0	0	29	440	21	274	144	25	0	0	5	14	14	28	.000	.257	.000	.257
2	Pete Rose P. Rose	308	1,584	0	1,271	111	0	0	0	31	273	16	168	12	7	0	0	10	14	33	26	.000	.184	.000	.184
3	Eddie Yost E. Yost	286	1,472	0	1,036	148	0	0	0	23	389	25	184	10	5	0	0	19	3	3	26	.000	.285	.000	.285
4	Joe Morgan J. Morgan	273	1,401	0	1,007	137	0	0	0	36	363	5	143	58	15	0	0	15	11	12	17	.000	.266	.000	.266
5	Donie Bush D. Bush	265	1,366	0	1,023	121	0	0	0	29	262	9		48		0	0	72				.000	.209	.000	.209
6	Barry Bonds B. Bonds	263	1,341	0	921	113	0	0	0	28	388	17	224	45	11	0	0	1	14	130	19	.000	.302	.000	.302
7	Craig Biggio C. Biggio	262	1,334	0	1,063	106	0	0	0	29	194	51	239	29	8	0	0	17	9	10	15	.000	.186	.000	.186
8	Jimmy Rollins J. Rollins	250	1,281	0	1,083	76	0	0	0	15	176	6	210	30	9	0	0	9	7	4	20	.000	.143	.000	.143
9	Johnny Damon J. Damon	249	1,278	0	1,060	88	0	0	0	29	195	5	192	37	7	0	0	8	10	11	15	.000	.157	.000	.157
10	Luis Aparicio L. Aparicio	242	1,254	0	1,084	80	0	0	0	22	123	3	96	39	9	0	0	30	14	4	29	.000	.103	.000	.103
11	Paul Molitor P. Molitor	238	1,215	0	999	86	0	0	0	29	179	6	174	30	6	0	0	13	18	10	31	.000	.154	.000	.154
12	Harry Hooper H. Hooper	238	1,224	0	943	94	0	0	0		217	17		28		0	0	47				.000	.199	.000	.199
13	Tony Phillips T. Phillips	235	1,204	0	921	109	0	0	0	30	249	10	253	14	12	0	0	9	15	7	17	.000	.217	.000	.217
14	Brady Anderson B. Anderson	228	1,157	0	914	85	0	0	0	22	181	41	219	29	7	0	0	13	8	13	12	.000	.194	.000	.194
15	Alex Rodriguez A. Rodriguez	224	1,139	0	893	73	0	0	0	30	205	25	256	11	7	0	0	3	13	14	34	.000	.202	.000	.202
16	Carl Yastrzemski C. Yastrzemski	224	1,149	0	898	61	0	0	0	31	235	0	149	13	7	0	0	1	15	29	39	.000	.205	.000	.205
17	Derek Jeter D. Jeter	223	1,141	0	943	82	0	0	0	28	150	23	215	10	6	0	0	16	9	6	30	.000	.154	.000	.154
18	Tim Raines T. Raines	223	1,135	0	887	82	0	0	0	24	226	10	132	48	8	0	0	6	6	28	21	.000	.209	.000	.209
19	Kenny Lofton K. Lofton	216	1,102	0	906	68	0	0	0	25	167	5	151	32	13	0	0	10	14	6	23	.000	.158	.000	.158
20	Omar Vizquel O. Vizquel	214	1,085	0	912	60	0	0	0	24	121	9	143	21	7	0	0	28	15	5	20	.000	.123	.000	.123
21	Brett Butler B. Butler	214	1,091	0	876	79	0	0	0	19	177	6	128	37	10	0	0	28	4	6	11	.000	.172	.000	.172
22	Lou Whitaker L. Whitaker	213	1,096	0	857	78	0	0	0	32	198	2	153	9	2	0	0	25	14	13	17	.000	.187	.000	.187
23	Ozzie Smith O. Smith	211	1,089	0	857	70	0	0	0	27	176	3	85	39	6	0	0	44	9	9	17	.000	.171	.000	.171
24	Rabbit Maranville R. Maranville	211	1,081	0	923	68	0	0	0	17	102	9	82	13		0	0	47				.000	.107	.000	.107
25	Jim Gilliam J. Gilliam	209	1,077	0	859	93	0	0	0	17	191	6	66	18	8	0	0	18	3	1	13	.000	.186	.000	.186