Phil Niekro had the most games pitched when facing 5+ batters, with 812 games.

Interpreted as:

most regular-season games by a player with 5+ tbf

	NAME	G	TBF	W	L	W%	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Phil Niekro P. Niekro	812	22,531	313	273	.534	716	3.36	3,316	245	45	19	5368.1	5,023	2,005	2,328	482	1,789	123	53	85	223	5.56	3.00	1.85	0.81	14.7	7.9	1.27	.270	3.90	8.42
2	Nolan Ryan N. Ryan	794	22,542	323	292	.525	768	3.20	5,705	222	61	2	5378.0	3,920	1,910	2,176	321	2,789	158	10	78	274	9.55	4.67	2.05	0.54	25.3	12.4	1.25	.265	3.64	6.56
3	Don Sutton D. Sutton	767	21,615	324	254	.561	755	3.26	3,574	178	58	2	5278.2	4,687	1,910	2,100	470	1,342	82	7	102	111	6.09	2.29	2.66	0.80	16.5	6.2	1.14	.261	3.58	7.99
4	Charlie Hough C. Hough	765	15,876	213	207	.507	440	3.78	2,308	107	13	40	3726.0	3,242	1,563	1,781	377	1,632	173	176	43	175	5.57	3.94	1.41	0.91	14.5	10.3	1.31	.252	4.30	7.83
5	Jim Kaat J. Kaat	761	18,691	278	230	.547	624	3.45	2,439	180	31	8	4451.2	4,529	1,705	1,997	390	1,063	120	60	109	125	4.93	2.15	2.29	0.79	13.0	5.7	1.26	.282	4.04	9.16
6	Gaylord Perry G. Perry	753	21,887	311	263	.542	690	3.10	3,518	303	53	8	5336.0	4,920	1,839	2,119	399	1,373	108	26	161	158	5.93	2.32	2.56	0.67	16.1	6.3	1.18	.274	3.57	8.30
7	Hoyt Wilhelm H. Wilhelm	753	8,212	122	111	.524	52	2.57	1,427	20	5	147	2005.2	1,588	573	701	129	708	55	428	57	75	6.40	3.18	2.02	0.58	17.4	8.6	1.14	.248	3.15	7.13
8	Greg Maddux G. Maddux	741	20,412	355	226	.611	738	3.15	3,370	109	35	0	5006.1	4,722	1,754	1,979	352	999	137	2	177	70	6.06	1.80	3.37	0.63	16.5	4.9	1.14	.281	3.56	8.49
9	Tommy John T. John	733	19,628	288	230	.556	698	3.34	2,238	162	46	0	4696.2	4,767	1,744	2,010	301	1,248	98	11	102	187	4.29	2.39	1.79	0.58	11.4	6.4	1.28	.284	3.85	9.13
10	Steve Carlton S. Carlton	728	21,651	329	243	.575	709	3.22	4,130	254	55	2	5210.1	4,667	1,862	2,127	414	1,830	53	9	150	180	7.13	3.16	2.26	0.72	19.1	8.5	1.25	.279	3.67	8.06
11	Warren Spahn W. Spahn	711	21,441	363	241	.601	664	3.09	2,563	382	63	8	5214.1	4,816	1,790	2,005	433	1,424	40	38	59	76	4.42	2.46	1.80	0.75	12.0	6.6	1.20	.258	3.46	8.31
12	Roger Clemens R. Clemens	707	20,234	354	183	.659	705	3.12	4,672	118	46	0	4916.1	4,183	1,702	1,880	363	1,578	158	0	63	143	8.55	2.89	2.96	0.66	23.1	7.8	1.17	.284	3.44	7.66
13	Lindy McDaniel L. McDaniel	691	8,111	118	105	.529	74	3.48	1,205	18	2	94	1924.2	1,898	745	848	157	574	15	380	128	93	5.63	2.68	2.10	0.73	14.9	7.1	1.28	.283	3.97	8.88
14	Bert Blyleven B. Blyleven	689	20,482	287	249	.535	685	3.31	3,701	242	60	0	4968.2	4,627	1,829	2,028	430	1,321	155	1	70	114	6.70	2.39	2.80	0.78	18.1	6.4	1.20	.282	3.67	8.38
15	Jamie Moyer J. Moyer	681	17,313	269	208	.564	638	4.25	2,437	33	10	0	4064.2	4,218	1,920	2,069	521	1,153	146	10	69	56	5.40	2.55	2.11	1.15	14.1	6.7	1.32	.283	4.58	9.34
16	Tom Glavine T. Glavine	680	18,596	305	201	.603	680	3.53	2,607	56	25	0	4413.1	4,291	1,729	1,894	356	1,499	66	0	145	65	5.32	3.06	1.74	0.73	14.0	8.1	1.31	.280	3.86	8.75
17	Early Wynn E. Wynn	667	19,334	299	242	.553	609	3.53	2,333	289	49	9	4546.1	4,274	1,781	2,025	334	1,770	64	48	36	53	4.62	3.50	1.32	0.66	12.1	9.2	1.33	.266	4.01	8.46
18	Dennis Martinez D. Martinez	656	16,648	243	192	.559	560	3.71	2,135	122	30	4	3972.1	3,878	1,637	1,829	370	1,157	121	39	70	82	4.84	2.62	1.85	0.84	12.8	6.9	1.27	.273	4.14	8.79
19	Rich Gossage R. Gossage	649	6,473	91	90	.503	37	3.16	1,251	16	0	188	1539.1	1,337	540	601	99	642	39	426	80	54	7.31	3.75	1.95	0.58	19.3	9.9	1.29	.279	3.51	7.82
20	Robin Roberts R. Roberts	649	19,145	284	244	.538	608	3.41	2,350	305	45	10	4668.1	4,568	1,768	1,957	504	895	54	29	71	33	4.53	1.73	2.63	0.97	12.3	4.7	1.17	.265	3.77	8.81
21	Tom Seaver T. Seaver	648	19,350	310	204	.603	645	2.86	3,636	231	61	0	4778.1	3,968	1,519	1,672	380	1,387	76	2	116	124	6.85	2.61	2.62	0.72	18.8	7.2	1.12	.259	3.15	7.47
22	Fergie Jenkins F. Jenkins	645	18,359	284	226	.557	594	3.34	3,180	267	49	3	4489.1	4,133	1,668	1,852	483	994	84	25	115	62	6.38	1.99	3.20	0.97	17.3	5.4	1.14	.268	3.71	8.29
23	Joe Niekro J. Niekro	632	14,961	218	200	.522	497	3.59	1,716	107	29	8	3535.1	3,416	1,412	1,601	274	1,244	63	53	68	168	4.37	3.17	1.38	0.70	11.5	8.3	1.32	.269	4.08	8.70
24	Frank Tanana F. Tanana	631	17,630	240	236	.504	615	3.66	2,771	143	34	0	4186.1	4,061	1,702	1,910	448	1,252	129	6	114	118	5.96	2.69	2.21	0.96	15.7	7.1	1.27	.277	4.11	8.73
25	Dennis Eckersley D. Eckersley	630	12,181	180	159	.531	360	3.79	2,047	100	20	130	2902.1	2,883	1,221	1,324	322	706	71	205	83	26	6.35	2.19	2.90	1.00	16.8	5.8	1.24	.283	4.11	8.94