Before September 26, 1991, Ty Cobb had the most runs, with 2,246 runs.

Interpreted as:

most runs by a player through september 25, 1991

	NAME	R	G	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Ty Cobb T. Cobb	2,246	3,032	11,443	4,189	723	298	117		1,261	95		900		13,090	5,859	1,138	296				.366		.512
2	Hank Aaron H. Aaron	2,175	3,298	12,364	3,771	624	98	755	2,297	1,403	32	1,381	240	73	13,941	6,856	1,477	21	121	293	330	.305	.374	.555	.929
3	Babe Ruth B. Ruth	2,173	2,504	8,400	2,873	506	136	714	2,213	2,062	44	1,331	123		10,622	5,793	1,356	116				.342	.474	.690	1.164
4	Pete Rose P. Rose	2,165	3,562	14,053	4,256	746	135	160	1,314	1,566	107	1,143	198	148	15,861	5,752	1,041	56	79	167	250	.303	.375	.409	.784
5	Willie Mays W. Mays	2,060	2,992	10,881	3,283	523	140	660	1,903	1,467	44	1,527	338	102	12,496	6,066	1,323	13	91	193	253	.302	.384	.557	.942
6	Stan Musial S. Musial	1,949	3,026	10,971	3,630	726	177	475	1,950	1,605	53	698	78	31	12,718	6,135	1,378	36	53	127	249	.331	.417	.559	.976
7	Lou Gehrig L. Gehrig	1,888	2,164	8,001	2,721	534	163	493	1,998	1,511	46	789	102		9,664	5,060	1,190	106			2	.340	.448	.632	1.080
8	Tristram Speaker T. Speaker	1,881	2,792	10,199	3,515	794	221	117		1,393	105		437		12,011	5,102	1,132	314				.345	.429	.500	.929
9	Mel Ott M. Ott	1,859	2,730	9,455	2,876	488	72	511	1,865	1,720	64	895	89		11,348	5,041	1,071	109			38	.304	.415	.533	.948
10	Frank Robinson F. Robinson	1,830	2,808	10,006	2,943	528	72	586	1,812	1,418	198	1,532	203	79	11,741	5,373	1,186	17	102	218	279	.294	.389	.537	.926
11	Eddie Collins E. Collins	1,822	2,825	9,955	3,311	438	187	47		1,533	77		741		12,081	4,264	672	516				.333	.426	.428	.854
12	Carl Yastrzemski C. Yastrzemski	1,816	3,308	11,988	3,419	646	59	452	1,844	1,845	40	1,395	168	115	13,991	5,539	1,157	13	105	190	325	.285	.379	.462	.841
13	Ted Williams T. Williams	1,799	2,292	7,706	2,654	525	71	521	1,839	2,018	39	709	24	5	9,788	4,884	1,117	5	20	89	201	.344	.482	.634	1.115
14	Charlie Gehringer C. Gehringer	1,775	2,323	8,860	2,839	574	146	184	1,434	1,193	51	372	182		10,244	4,257	904	140			27	.320	.404	.480	.885
15	Jimmie Foxx J. Foxx	1,751	2,317	8,134	2,645	458	125	534	1,924	1,457	13	1,311	87		9,676	4,955	1,117	72			70	.325	.428	.609	1.038
16	Mickey Mantle M. Mantle	1,675	2,401	8,101	2,415	344	72	536	1,509	1,733	12	1,718	152	42	9,907	4,511	952	14	47	126	113	.298	.420	.557	.977
17	Joe Morgan J. Morgan	1,650	2,649	9,277	2,517	449	96	268	1,133	1,865	40	1,015	689	162	11,329	3,962	813	51	96	76	105	.271	.392	.427	.819
18	Paul Waner P. Waner	1,627	2,550	9,460	3,152	605	191	113	1,316	1,093	38	376	104		10,766	4,478	909	175			45	.333	.404	.473	.878
19	Al Kaline A. Kaline	1,622	2,834	10,116	3,007	498	75	399	1,582	1,276	55	1,020	137	68	11,596	4,852	972	45	104	133	276	.297	.376	.480	.855
20	Lou Brock L. Brock	1,610	2,616	10,332	3,023	486	141	149	900	761	49	1,730	938	306	11,235	4,238	776	47	46	124	115	.293	.343	.410	.753
21	Rogers Hornsby R. Hornsby	1,579	2,259	8,172	2,930	541	169	301		1,041	48	677	135		9,477	4,712	1,011	216				.359	.434	.577	1.011
22	Reggie Jackson R. Jackson	1,551	2,820	9,864	2,584	463	49	563	1,702	1,376	96	2,596	228	115	11,417	4,834	1,075	13	68	164	183	.262	.356	.490	.846
23	Max Carey M. Carey	1,545	2,466	9,365	2,665	419	159	70		1,038	77	694	740		10,765	3,612	648	285				.285	.361	.386	.746
24	Frankie Frisch F. Frisch	1,532	2,311	9,113	2,879	466	139	105	1,243	729	31	272	419		10,099	3,938	710	226				.316	.369	.432	.801
25	Sam Rice S. Rice	1,514	2,405	9,275	2,986	498	184	34		709	57	274	352		10,252	3,954	716	211				.322	.374	.426	.800