Between May 17, 1967 and September 16, 2007, Nolan Ryan fanned the most batters, with 5,708 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | N. Ryan | 5,708 | 805 | 324 | 291 | .527 | 772 | 3.19 | 222 | 61 | 3 | 5383.0 | 3,918 | 1,906 | 2,173 | 320 | 2,792 | 158 | 13 | 77 | 22,558 | 276 | 9.54 | 4.67 | 2.04 | 0.54 | 25.3 | 12.4 | 1.25 | .265 | 3.63 | 6.55 |
| 2 |  | R. Clemens | 4,672 | 709 | 354 | 184 | .658 | 707 | 3.12 | 118 | 46 | 0 | 4916.2 | 4,185 | 1,707 | 1,885 | 363 | 1,580 | 159 | 0 | 63 | 20,240 | 143 | 8.55 | 2.89 | 2.96 | 0.66 | 23.1 | 7.8 | 1.17 | .284 | 3.45 | 7.66 |
| 3 |  | R. Johnson | 4,616 | 566 | 284 | 150 | .654 | 556 | 3.22 | 98 | 37 | 2 | 3855.1 | 3,065 | 1,381 | 1,556 | 368 | 1,422 | 182 | 5 | 29 | 15,877 | 102 | 10.78 | 3.32 | 3.25 | 0.86 | 29.1 | 9.0 | 1.16 | .290 | 3.63 | 7.16 |
| 4 |  | S. Carlton | 4,068 | 713 | 324 | 240 | .574 | 696 | 3.22 | 252 | 54 | 1 | 5121.2 | 4,575 | 1,832 | 2,094 | 408 | 1,800 | 52 | 7 | 148 | 21,280 | 174 | 7.15 | 3.16 | 2.26 | 0.72 | 19.1 | 8.5 | 1.24 | .279 | 3.68 | 8.04 |
| 5 |  | B. Blyleven | 3,701 | 692 | 287 | 250 | .534 | 685 | 3.31 | 242 | 60 | 0 | 4970.0 | 4,632 | 1,830 | 2,029 | 430 | 1,322 | 155 | 3 | 71 | 20,492 | 114 | 6.70 | 2.39 | 2.80 | 0.78 | 18.1 | 6.5 | 1.20 | .282 | 3.67 | 8.39 |
| 6 |  | T. Seaver | 3,615 | 650 | 308 | 204 | .602 | 641 | 2.87 | 229 | 61 | 1 | 4742.1 | 3,931 | 1,511 | 1,663 | 378 | 1,378 | 74 | 6 | 117 | 19,198 | 123 | 6.86 | 2.62 | 2.62 | 0.72 | 18.8 | 7.2 | 1.12 | .258 | 3.16 | 7.46 |
| 7 | | D. Sutton | 3,331 | 730 | 312 | 240 | .565 | 714 | 3.26 | 172 | 56 | 5 | 5011.2 | 4,452 | 1,813 | 1,994 | 449 | 1,274 | 77 | 12 | 97 | 20,521 | 107 | 5.98 | 2.29 | 2.61 | 0.81 | 16.2 | 6.2 | 1.14 | .260 | 3.58 | 7.99 |
| 8 |  | G. Maddux | 3,267 | 708 | 345 | 213 | .618 | 704 | 3.10 | 109 | 35 | 0 | 4800.2 | 4,501 | 1,654 | 1,865 | 330 | 965 | 130 | 3 | 172 | 19,551 | 67 | 6.12 | 1.81 | 3.39 | 0.62 | 16.7 | 4.9 | 1.14 | .281 | 3.50 | 8.44 |
| 9 | | P. Niekro | 3,248 | 770 | 312 | 266 | .540 | 715 | 3.36 | 245 | 45 | 15 | 5234.0 | 4,886 | 1,952 | 2,253 | 471 | 1,743 | 117 | 39 | 77 | 21,940 | 212 | 5.59 | 3.00 | 1.86 | 0.81 | 14.8 | 7.9 | 1.27 | .270 | 3.87 | 8.40 |
| 10 | | C. Schilling | 3,110 | 568 | 215 | 146 | .596 | 435 | 3.46 | 83 | 20 | 22 | 3255.0 | 2,992 | 1,252 | 1,317 | 346 | 711 | 52 | 81 | 43 | 13,261 | 72 | 8.60 | 1.97 | 4.37 | 0.96 | 23.5 | 5.4 | 1.14 | .293 | 3.64 | 8.27 |
| 11 |  | P. Martinez | 3,015 | 445 | 208 | 92 | .693 | 378 | 2.80 | 46 | 17 | 3 | 2661.2 | 2,031 | 828 | 911 | 213 | 705 | 131 | 23 | 27 | 10,655 | 60 | 10.19 | 2.38 | 4.28 | 0.72 | 28.3 | 6.6 | 1.03 | .276 | 3.08 | 6.87 |
| 12 | | F. Jenkins | 2,994 | 588 | 273 | 214 | .561 | 574 | 3.35 | 262 | 47 | 1 | 4253.1 | 3,944 | 1,581 | 1,756 | 453 | 923 | 81 | 9 | 103 | 17,401 | 60 | 6.34 | 1.95 | 3.24 | 0.96 | 17.2 | 5.3 | 1.14 | .270 | 3.72 | 8.35 |
| 13 |  | J. Smoltz | 2,955 | 699 | 206 | 144 | .589 | 458 | 3.26 | 53 | 16 | 154 | 3349.0 | 2,941 | 1,213 | 1,319 | 271 | 980 | 54 | 204 | 81 | 13,740 | 142 | 7.94 | 2.63 | 3.02 | 0.73 | 21.5 | 7.1 | 1.17 | .282 | 3.54 | 7.90 |
| 14 | | G. Perry | 2,899 | 598 | 268 | 224 | .545 | 591 | 3.04 | 276 | 47 | 3 | 4515.0 | 4,131 | 1,525 | 1,772 | 327 | 1,174 | 89 | 7 | 128 | 18,469 | 127 | 5.78 | 2.34 | 2.47 | 0.65 | 15.7 | 6.4 | 1.17 | .272 | 3.53 | 8.23 |
| 15 | | F. Tanana | 2,773 | 638 | 240 | 236 | .504 | 616 | 3.66 | 143 | 34 | 1 | 4188.1 | 4,063 | 1,702 | 1,910 | 448 | 1,255 | 129 | 10 | 116 | 17,641 | 119 | 5.96 | 2.70 | 2.21 | 0.96 | 15.7 | 7.1 | 1.27 | .277 | 4.10 | 8.73 |
| 16 | | D. Cone | 2,668 | 450 | 194 | 126 | .606 | 419 | 3.47 | 56 | 22 | 1 | 2898.2 | 2,504 | 1,116 | 1,222 | 258 | 1,137 | 106 | 9 | 42 | 12,184 | 149 | 8.28 | 3.53 | 2.35 | 0.80 | 21.9 | 9.3 | 1.26 | .280 | 3.79 | 7.77 |
| 17 | | M. Mussina | 2,650 | 500 | 248 | 144 | .633 | 499 | 3.70 | 57 | 23 | 0 | 3343.1 | 3,225 | 1,374 | 1,465 | 359 | 751 | 52 | 0 | 26 | 13,698 | 67 | 7.13 | 2.02 | 3.53 | 0.97 | 19.3 | 5.5 | 1.19 | .290 | 3.94 | 8.68 |
| 18 | | C. Finley | 2,610 | 524 | 200 | 173 | .536 | 467 | 3.85 | 63 | 15 | 0 | 3197.1 | 3,069 | 1,366 | 1,517 | 304 | 1,332 | 76 | 24 | 36 | 13,638 | 130 | 7.35 | 3.75 | 1.96 | 0.86 | 19.1 | 9.8 | 1.38 | .297 | 4.27 | 8.64 |
| 19 | | T. Glavine | 2,563 | 666 | 303 | 197 | .606 | 666 | 3.48 | 56 | 25 | 0 | 4339.2 | 4,206 | 1,678 | 1,843 | 341 | 1,459 | 64 | 0 | 141 | 18,265 | 65 | 5.32 | 3.03 | 1.76 | 0.71 | 14.0 | 8.0 | 1.31 | .279 | 3.82 | 8.72 |
| 20 | | J. Koosman | 2,553 | 607 | 222 | 209 | .515 | 527 | 3.36 | 140 | 33 | 17 | 3830.0 | 3,626 | 1,428 | 1,601 | 289 | 1,190 | 71 | 42 | 118 | 15,950 | 89 | 6.00 | 2.80 | 2.15 | 0.68 | 16.0 | 7.5 | 1.26 | .282 | 3.76 | 8.52 |
| 21 |  | J. Morris | 2,478 | 549 | 254 | 186 | .577 | 527 | 3.90 | 175 | 28 | 0 | 3824.0 | 3,567 | 1,657 | 1,815 | 389 | 1,390 | 58 | 10 | 99 | 16,120 | 205 | 5.83 | 3.27 | 1.78 | 0.92 | 15.4 | 8.6 | 1.30 | .269 | 4.27 | 8.40 |
| 22 | | M. Langston | 2,464 | 457 | 179 | 158 | .531 | 428 | 3.97 | 81 | 18 | 0 | 2962.2 | 2,723 | 1,306 | 1,438 | 311 | 1,289 | 46 | 3 | 34 | 12,562 | 89 | 7.49 | 3.92 | 1.91 | 0.94 | 19.6 | 10.3 | 1.35 | .285 | 4.37 | 8.27 |
| 23 | | D. Eckersley | 2,401 | 1,071 | 197 | 171 | .535 | 361 | 3.50 | 100 | 20 | 390 | 3285.2 | 3,076 | 1,279 | 1,382 | 347 | 738 | 75 | 577 | 90 | 13,534 | 28 | 6.58 | 2.02 | 3.25 | 0.95 | 17.7 | 5.5 | 1.16 | .274 | 3.79 | 8.43 |
| 24 | | K. Brown | 2,397 | 486 | 211 | 144 | .594 | 476 | 3.28 | 72 | 17 | 0 | 3256.1 | 3,079 | 1,185 | 1,357 | 208 | 901 | 139 | 1 | 42 | 13,542 | 108 | 6.62 | 2.49 | 2.66 | 0.57 | 17.7 | 6.7 | 1.22 | .290 | 3.75 | 8.51 |
| 25 | | C. Hough | 2,362 | 858 | 216 | 216 | .500 | 440 | 3.75 | 107 | 13 | 61 | 3801.1 | 3,283 | 1,582 | 1,807 | 383 | 1,664 | 174 | 240 | 44 | 16,168 | 180 | 5.59 | 3.94 | 1.42 | 0.91 | 14.6 | 10.3 | 1.30 | .250 | 4.28 | 7.77 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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