Between May 25, 1966 and September 4, 2023, Nolan Ryan struck out the most batters, with 5,714 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | N. Ryan | 5,714 | 807 | 324 | 292 | .526 | 773 | 3.19 | 222 | 61 | 3 | 5386.0 | 3,923 | 1,911 | 2,178 | 321 | 2,795 | 158 | 13 | 78 | 22,575 | 277 | 9.55 | 4.67 | 2.04 | 0.54 | 25.3 | 12.4 | 1.25 | .265 | 3.64 | 6.56 |
| 2 |  | R. Johnson | 4,875 | 618 | 303 | 166 | .646 | 603 | 3.29 | 100 | 37 | 2 | 4135.1 | 3,346 | 1,513 | 1,703 | 411 | 1,497 | 190 | 7 | 37 | 17,067 | 109 | 10.61 | 3.26 | 3.26 | 0.89 | 28.6 | 8.8 | 1.17 | .291 | 3.71 | 7.28 |
| 3 |  | R. Clemens | 4,672 | 709 | 354 | 184 | .658 | 707 | 3.12 | 118 | 46 | 0 | 4916.2 | 4,185 | 1,707 | 1,885 | 363 | 1,580 | 159 | 0 | 63 | 20,240 | 143 | 8.55 | 2.89 | 2.96 | 0.66 | 23.1 | 7.8 | 1.17 | .284 | 3.45 | 7.66 |
| 4 |  | S. Carlton | 4,115 | 726 | 329 | 244 | .574 | 707 | 3.22 | 254 | 55 | 2 | 5192.2 | 4,645 | 1,857 | 2,123 | 411 | 1,825 | 52 | 8 | 149 | 21,578 | 178 | 7.13 | 3.16 | 2.25 | 0.71 | 19.1 | 8.5 | 1.25 | .279 | 3.68 | 8.05 |
| 5 |  | B. Blyleven | 3,701 | 692 | 287 | 250 | .534 | 685 | 3.31 | 242 | 60 | 0 | 4970.0 | 4,632 | 1,830 | 2,029 | 430 | 1,322 | 155 | 3 | 71 | 20,492 | 114 | 6.70 | 2.39 | 2.80 | 0.78 | 18.1 | 6.5 | 1.20 | .282 | 3.67 | 8.39 |
| 6 |  | T. Seaver | 3,640 | 656 | 311 | 205 | .603 | 647 | 2.86 | 231 | 61 | 1 | 4783.0 | 3,971 | 1,521 | 1,674 | 380 | 1,390 | 76 | 6 | 117 | 19,369 | 125 | 6.85 | 2.62 | 2.62 | 0.72 | 18.8 | 7.2 | 1.12 | .259 | 3.15 | 7.47 |
| 7 | | D. Sutton | 3,515 | 764 | 318 | 252 | .558 | 746 | 3.27 | 176 | 57 | 5 | 5214.0 | 4,629 | 1,893 | 2,082 | 468 | 1,334 | 80 | 12 | 102 | 21,354 | 111 | 6.07 | 2.30 | 2.63 | 0.81 | 16.5 | 6.2 | 1.14 | .261 | 3.59 | 7.99 |
| 8 |  | G. Maddux | 3,371 | 744 | 355 | 227 | .610 | 740 | 3.16 | 109 | 35 | 0 | 5008.1 | 4,726 | 1,756 | 1,981 | 353 | 999 | 137 | 3 | 177 | 20,421 | 70 | 6.06 | 1.80 | 3.37 | 0.63 | 16.5 | 4.9 | 1.14 | .281 | 3.56 | 8.49 |
| 9 |  | M. Scherzer | 3,361 | 455 | 212 | 107 | .665 | 446 | 3.13 | 12 | 5 | 0 | 2826.1 | 2,297 | 984 | 1,056 | 325 | 743 | 111 | 2 | 20 | 11,415 | 75 | 10.70 | 2.37 | 4.52 | 1.03 | 29.4 | 6.5 | 1.08 | .287 | 3.36 | 7.31 |
| 10 |  | J. Verlander | 3,311 | 504 | 254 | 140 | .645 | 504 | 3.24 | 26 | 9 | 0 | 3292.1 | 2,768 | 1,187 | 1,287 | 337 | 919 | 109 | 0 | 27 | 13,419 | 94 | 9.05 | 2.51 | 3.60 | 0.92 | 24.7 | 6.8 | 1.12 | .278 | 3.52 | 7.57 |
| 11 | | P. Niekro | 3,278 | 801 | 314 | 268 | .540 | 715 | 3.35 | 245 | 45 | 23 | 5295.0 | 4,937 | 1,972 | 2,280 | 474 | 1,765 | 117 | 56 | 79 | 22,195 | 215 | 5.57 | 3.00 | 1.86 | 0.81 | 14.8 | 8.0 | 1.27 | .269 | 3.88 | 8.39 |
| 12 |  | P. Martinez | 3,154 | 476 | 219 | 100 | .687 | 409 | 2.93 | 46 | 17 | 3 | 2827.1 | 2,221 | 919 | 1,006 | 239 | 760 | 141 | 23 | 30 | 11,394 | 62 | 10.04 | 2.42 | 4.15 | 0.76 | 27.7 | 6.7 | 1.05 | .279 | 3.20 | 7.07 |
| 13 | | F. Jenkins | 3,152 | 645 | 281 | 225 | .555 | 593 | 3.34 | 267 | 49 | 4 | 4454.1 | 4,110 | 1,652 | 1,835 | 477 | 986 | 83 | 25 | 115 | 18,217 | 62 | 6.37 | 1.99 | 3.20 | 0.96 | 17.3 | 5.4 | 1.14 | .269 | 3.71 | 8.30 |
| 14 | | C. Schilling | 3,116 | 569 | 216 | 146 | .597 | 436 | 3.46 | 83 | 20 | 22 | 3261.0 | 2,998 | 1,253 | 1,318 | 347 | 711 | 52 | 81 | 43 | 13,284 | 72 | 8.60 | 1.96 | 4.38 | 0.96 | 23.5 | 5.4 | 1.14 | .293 | 3.64 | 8.27 |
| 15 |  | CC Sabathia | 3,093 | 561 | 251 | 161 | .609 | 560 | 3.74 | 38 | 12 | 0 | 3577.1 | 3,404 | 1,485 | 1,623 | 382 | 1,099 | 123 | 0 | 44 | 14,989 | 74 | 7.78 | 2.76 | 2.81 | 0.96 | 20.6 | 7.3 | 1.26 | .294 | 4.08 | 8.56 |
| 16 | | G. Perry | 3,089 | 633 | 284 | 234 | .548 | 626 | 3.04 | 288 | 50 | 3 | 4772.1 | 4,372 | 1,613 | 1,866 | 349 | 1,213 | 94 | 7 | 132 | 19,509 | 136 | 5.83 | 2.29 | 2.55 | 0.66 | 15.8 | 6.2 | 1.17 | .272 | 3.52 | 8.25 |
| 17 |  | J. Smoltz | 3,084 | 723 | 213 | 155 | .579 | 481 | 3.33 | 53 | 16 | 154 | 3473.0 | 3,074 | 1,284 | 1,391 | 288 | 1,010 | 57 | 204 | 84 | 14,271 | 145 | 7.99 | 2.62 | 3.05 | 0.75 | 21.6 | 7.1 | 1.18 | .283 | 3.60 | 7.97 |
| 18 |  | Z. Greinke | 2,962 | 581 | 224 | 155 | .591 | 537 | 3.49 | 17 | 5 | 1 | 3370.0 | 3,188 | 1,308 | 1,403 | 366 | 757 | 79 | 8 | 25 | 13,798 | 101 | 7.91 | 2.02 | 3.91 | 0.98 | 21.5 | 5.5 | 1.17 | .293 | 3.75 | 8.51 |
| 19 |  | C. Kershaw | 2,927 | 421 | 209 | 91 | .697 | 418 | 2.48 | 25 | 15 | 0 | 2693.1 | 2,041 | 742 | 811 | 222 | 658 | 42 | 1 | 27 | 10,604 | 100 | 9.78 | 2.20 | 4.45 | 0.74 | 27.6 | 6.2 | 1.00 | .269 | 2.71 | 6.82 |
| 20 | | M. Mussina | 2,813 | 537 | 270 | 153 | .638 | 536 | 3.68 | 57 | 23 | 0 | 3562.2 | 3,460 | 1,458 | 1,559 | 376 | 785 | 60 | 0 | 29 | 14,593 | 71 | 7.11 | 1.98 | 3.58 | 0.95 | 19.3 | 5.4 | 1.19 | .292 | 3.94 | 8.74 |
| 21 | | F. Tanana | 2,773 | 638 | 240 | 236 | .504 | 616 | 3.66 | 143 | 34 | 1 | 4188.1 | 4,063 | 1,702 | 1,910 | 448 | 1,255 | 129 | 10 | 116 | 17,641 | 119 | 5.96 | 2.70 | 2.21 | 0.96 | 15.7 | 7.1 | 1.27 | .277 | 4.10 | 8.73 |
| 22 | | D. Cone | 2,668 | 450 | 194 | 126 | .606 | 419 | 3.47 | 56 | 22 | 1 | 2898.2 | 2,504 | 1,116 | 1,222 | 258 | 1,137 | 106 | 9 | 42 | 12,184 | 149 | 8.28 | 3.53 | 2.35 | 0.80 | 21.9 | 9.3 | 1.26 | .280 | 3.79 | 7.77 |
| 23 | | C. Finley | 2,610 | 524 | 200 | 173 | .536 | 467 | 3.85 | 63 | 15 | 0 | 3197.1 | 3,069 | 1,366 | 1,517 | 304 | 1,332 | 76 | 24 | 36 | 13,638 | 130 | 7.35 | 3.75 | 1.96 | 0.86 | 19.1 | 9.8 | 1.38 | .297 | 4.27 | 8.64 |
| 24 | | T. Glavine | 2,607 | 682 | 305 | 203 | .600 | 682 | 3.54 | 56 | 25 | 0 | 4413.1 | 4,298 | 1,734 | 1,900 | 356 | 1,500 | 66 | 0 | 145 | 18,604 | 65 | 5.32 | 3.06 | 1.74 | 0.73 | 14.0 | 8.1 | 1.31 | .280 | 3.87 | 8.76 |
| 25 | | C. Hamels | 2,560 | 423 | 163 | 122 | .572 | 422 | 3.43 | 17 | 7 | 0 | 2698.0 | 2,424 | 1,027 | 1,103 | 310 | 767 | 100 | 0 | 43 | 11,115 | 57 | 8.54 | 2.56 | 3.34 | 1.03 | 23.0 | 6.9 | 1.18 | .287 | 3.68 | 8.09 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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