Between May 31, 1901 and September 14, 2006, Nolan Ryan struck out the most hitters, with 5,714 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | N. Ryan | 5,714 | 807 | 324 | 292 | .526 | 773 | 3.19 | 222 | 61 | 3 | 5386.0 | 3,923 | 1,911 | 2,178 | 321 | 2,795 | 158 | 13 | 78 | 22,575 | 277 | 9.55 | 4.67 | 2.04 | 0.54 | 25.3 | 12.4 | 1.25 | .265 | 3.64 | 6.56 |
| 2 |  | R. Clemens | 4,581 | 687 | 347 | 176 | .663 | 686 | 3.11 | 118 | 46 | 0 | 4795.2 | 4,070 | 1,655 | 1,826 | 353 | 1,540 | 154 | 0 | 62 | 19,731 | 136 | 8.60 | 2.89 | 2.97 | 0.66 | 23.2 | 7.8 | 1.17 | .284 | 3.43 | 7.64 |
| 3 |  | R. Johnson | 4,531 | 554 | 280 | 146 | .657 | 544 | 3.20 | 98 | 37 | 2 | 3787.0 | 2,998 | 1,347 | 1,520 | 359 | 1,405 | 178 | 5 | 26 | 15,590 | 101 | 10.77 | 3.34 | 3.22 | 0.85 | 29.1 | 9.0 | 1.16 | .289 | 3.61 | 7.12 |
| 4 |  | S. Carlton | 4,136 | 741 | 329 | 244 | .574 | 709 | 3.22 | 254 | 55 | 2 | 5217.2 | 4,672 | 1,864 | 2,130 | 414 | 1,833 | 53 | 13 | 150 | 21,682 | 183 | 7.13 | 3.16 | 2.26 | 0.71 | 19.1 | 8.5 | 1.25 | .279 | 3.67 | 8.06 |
| 5 |  | B. Blyleven | 3,701 | 692 | 287 | 250 | .534 | 685 | 3.31 | 242 | 60 | 0 | 4970.0 | 4,632 | 1,830 | 2,029 | 430 | 1,322 | 155 | 3 | 71 | 20,492 | 114 | 6.70 | 2.39 | 2.80 | 0.78 | 18.1 | 6.5 | 1.20 | .282 | 3.67 | 8.39 |
| 6 |  | T. Seaver | 3,640 | 656 | 311 | 205 | .603 | 647 | 2.86 | 231 | 61 | 1 | 4783.0 | 3,971 | 1,521 | 1,674 | 380 | 1,390 | 76 | 6 | 117 | 19,369 | 125 | 6.85 | 2.62 | 2.62 | 0.72 | 18.8 | 7.2 | 1.12 | .259 | 3.15 | 7.47 |
| 7 | | D. Sutton | 3,574 | 774 | 324 | 256 | .559 | 756 | 3.26 | 178 | 58 | 5 | 5282.1 | 4,692 | 1,914 | 2,104 | 472 | 1,343 | 82 | 12 | 103 | 21,631 | 112 | 6.09 | 2.29 | 2.66 | 0.80 | 16.5 | 6.2 | 1.14 | .261 | 3.58 | 7.99 |
| 8 | | G. Perry | 3,534 | 777 | 314 | 265 | .542 | 690 | 3.11 | 303 | 53 | 10 | 5350.0 | 4,938 | 1,846 | 2,128 | 399 | 1,378 | 108 | 33 | 163 | 21,953 | 160 | 5.95 | 2.32 | 2.56 | 0.67 | 16.1 | 6.3 | 1.18 | .275 | 3.58 | 8.31 |
| 9 |  | W. Johnson | 3,527 | 802 | 417 | 279 | .599 | 666 | 1.70 | 531 | 110 | 34 | 5916.2 | 4,917 | 1,902 | 97 | 1,374 | 208 | 128 | 155 | 5.37 | 2.09 | 2.57 | 0.15 | 5.8 | 1.06 | .262 | 2.89 | 7.48 | ||||
| 10 | | P. Niekro | 3,342 | 864 | 318 | 274 | .537 | 716 | 3.35 | 245 | 45 | 29 | 5404.0 | 5,044 | 2,012 | 2,337 | 482 | 1,809 | 123 | 83 | 86 | 22,677 | 227 | 5.57 | 3.01 | 1.85 | 0.80 | 14.7 | 8.0 | 1.27 | .270 | 3.89 | 8.40 |
| 11 | | F. Jenkins | 3,191 | 664 | 284 | 226 | .557 | 594 | 3.34 | 267 | 49 | 7 | 4500.2 | 4,142 | 1,669 | 1,853 | 484 | 997 | 84 | 37 | 117 | 18,404 | 62 | 6.38 | 1.99 | 3.20 | 0.97 | 17.3 | 5.4 | 1.14 | .268 | 3.71 | 8.28 |
| 12 |  | G. Maddux | 3,156 | 673 | 330 | 202 | .620 | 669 | 3.07 | 108 | 35 | 0 | 4591.1 | 4,283 | 1,566 | 1,776 | 315 | 940 | 125 | 3 | 169 | 18,693 | 63 | 6.19 | 1.84 | 3.36 | 0.62 | 16.9 | 5.0 | 1.14 | .280 | 3.48 | 8.40 |
| 13 |  | B. Gibson | 3,117 | 528 | 251 | 174 | .591 | 482 | 2.91 | 255 | 56 | 6 | 3884.1 | 3,279 | 1,258 | 1,420 | 257 | 1,336 | 102 | 21 | 118 | 16,066 | 109 | 7.22 | 3.10 | 2.33 | 0.60 | 19.4 | 8.3 | 1.19 | .269 | 3.29 | 7.60 |
| 14 | | C. Schilling | 3,003 | 543 | 206 | 138 | .599 | 410 | 3.45 | 82 | 19 | 22 | 3098.0 | 2,820 | 1,186 | 1,248 | 326 | 684 | 50 | 81 | 42 | 12,600 | 72 | 8.72 | 1.99 | 4.39 | 0.95 | 23.8 | 5.4 | 1.13 | .292 | 3.63 | 8.19 |
| 15 |  | P. Martinez | 2,986 | 439 | 206 | 89 | .698 | 372 | 2.77 | 46 | 17 | 3 | 2635.0 | 1,995 | 811 | 892 | 211 | 697 | 127 | 23 | 26 | 10,526 | 57 | 10.20 | 2.38 | 4.28 | 0.72 | 28.4 | 6.6 | 1.02 | .274 | 3.05 | 6.81 |
| 16 | | J. Bunning | 2,855 | 591 | 224 | 184 | .549 | 519 | 3.27 | 151 | 40 | 16 | 3760.0 | 3,433 | 1,365 | 1,527 | 372 | 1,000 | 160 | 39 | 98 | 15,615 | 47 | 6.83 | 2.39 | 2.86 | 0.89 | 18.3 | 6.4 | 1.18 | .273 | 3.66 | 8.22 |
| 17 | | M. Lolich | 2,832 | 586 | 217 | 191 | .532 | 496 | 3.44 | 195 | 41 | 10 | 3638.1 | 3,366 | 1,390 | 1,537 | 347 | 1,099 | 91 | 40 | 67 | 15,139 | 123 | 7.01 | 2.72 | 2.58 | 0.86 | 18.7 | 7.3 | 1.23 | .280 | 3.80 | 8.33 |
| 18 | | F. Tanana | 2,773 | 638 | 240 | 236 | .504 | 616 | 3.66 | 143 | 34 | 1 | 4188.1 | 4,063 | 1,702 | 1,910 | 448 | 1,255 | 129 | 10 | 116 | 17,641 | 119 | 5.96 | 2.70 | 2.21 | 0.96 | 15.7 | 7.1 | 1.27 | .277 | 4.10 | 8.73 |
| 19 |  | J. Smoltz | 2,752 | 666 | 189 | 137 | .580 | 425 | 3.30 | 53 | 16 | 154 | 3132.1 | 2,729 | 1,147 | 1,246 | 256 | 929 | 49 | 204 | 71 | 12,834 | 134 | 7.91 | 2.67 | 2.96 | 0.74 | 21.4 | 7.2 | 1.17 | .279 | 3.58 | 7.84 |
| 20 | | D. Cone | 2,668 | 450 | 194 | 126 | .606 | 419 | 3.47 | 56 | 22 | 1 | 2898.2 | 2,504 | 1,116 | 1,222 | 258 | 1,137 | 106 | 9 | 42 | 12,184 | 149 | 8.28 | 3.53 | 2.35 | 0.80 | 21.9 | 9.3 | 1.26 | .280 | 3.79 | 7.77 |
| 21 | | C. Finley | 2,610 | 524 | 200 | 173 | .536 | 467 | 3.85 | 63 | 15 | 0 | 3197.1 | 3,069 | 1,366 | 1,517 | 304 | 1,332 | 76 | 24 | 36 | 13,638 | 130 | 7.35 | 3.75 | 1.96 | 0.86 | 19.1 | 9.8 | 1.38 | .297 | 4.27 | 8.64 |
| 22 | | W. Spahn | 2,583 | 750 | 363 | 245 | .597 | 665 | 3.09 | 382 | 63 | 28 | 5243.2 | 4,833 | 1,801 | 2,018 | 434 | 1,432 | 41 | 67 | 21,555 | 78 | 4.43 | 2.46 | 1.80 | 0.74 | 12.0 | 6.6 | 1.19 | .258 | 3.46 | 8.30 | |
| 23 | | B. Feller | 2,581 | 570 | 266 | 162 | .621 | 484 | 3.26 | 279 | 44 | 22 | 3827.0 | 3,271 | 1,385 | 1,557 | 223 | 1,764 | 60 | 52 | 6 | 16,172 | 69 | 6.07 | 4.15 | 1.46 | 0.52 | 16.0 | 10.9 | 1.32 | .264 | 3.66 | 7.69 |
| 24 | | M. Mussina | 2,559 | 472 | 238 | 133 | .642 | 472 | 3.64 | 57 | 23 | 0 | 3193.2 | 3,042 | 1,291 | 1,375 | 343 | 717 | 48 | 0 | 24 | 13,052 | 65 | 7.21 | 2.02 | 3.57 | 0.97 | 19.6 | 5.5 | 1.18 | .288 | 3.87 | 8.57 |
| 25 | | J. Koosman | 2,556 | 612 | 222 | 209 | .515 | 527 | 3.36 | 140 | 33 | 17 | 3839.1 | 3,635 | 1,433 | 1,608 | 290 | 1,198 | 71 | 43 | 121 | 15,996 | 89 | 5.99 | 2.81 | 2.13 | 0.68 | 16.0 | 7.5 | 1.26 | .282 | 3.77 | 8.52 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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