Between September 21, 1968 and May 22, 2010, Nolan Ryan struck out the most batters, with 5,575 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | N. Ryan | 5,575 | 784 | 318 | 282 | .530 | 754 | 3.19 | 219 | 61 | 3 | 5249.0 | 3,825 | 1,860 | 2,123 | 308 | 2,717 | 154 | 12 | 73 | 21,999 | 269 | 9.56 | 4.66 | 2.05 | 0.53 | 25.3 | 12.4 | 1.25 | .266 | 3.64 | 6.56 |
| 2 |  | R. Johnson | 4,875 | 618 | 303 | 166 | .646 | 603 | 3.29 | 100 | 37 | 2 | 4135.1 | 3,346 | 1,513 | 1,703 | 411 | 1,497 | 190 | 7 | 37 | 17,067 | 109 | 10.61 | 3.26 | 3.26 | 0.89 | 28.6 | 8.8 | 1.17 | .291 | 3.71 | 7.28 |
| 3 |  | R. Clemens | 4,672 | 709 | 354 | 184 | .658 | 707 | 3.12 | 118 | 46 | 0 | 4916.2 | 4,185 | 1,707 | 1,885 | 363 | 1,580 | 159 | 0 | 63 | 20,240 | 143 | 8.55 | 2.89 | 2.96 | 0.66 | 23.1 | 7.8 | 1.17 | .284 | 3.45 | 7.66 |
| 4 |  | S. Carlton | 3,761 | 654 | 299 | 221 | .575 | 638 | 3.24 | 231 | 47 | 1 | 4720.2 | 4,208 | 1,698 | 1,943 | 388 | 1,684 | 47 | 6 | 143 | 19,618 | 164 | 7.17 | 3.21 | 2.23 | 0.74 | 19.2 | 8.6 | 1.25 | .278 | 3.70 | 8.02 |
| 5 |  | B. Blyleven | 3,701 | 692 | 287 | 250 | .534 | 685 | 3.31 | 242 | 60 | 0 | 4970.0 | 4,632 | 1,830 | 2,029 | 430 | 1,322 | 155 | 3 | 71 | 20,492 | 114 | 6.70 | 2.39 | 2.80 | 0.78 | 18.1 | 6.5 | 1.20 | .282 | 3.67 | 8.39 |
| 6 |  | G. Maddux | 3,371 | 744 | 355 | 227 | .610 | 740 | 3.16 | 109 | 35 | 0 | 5008.1 | 4,726 | 1,756 | 1,981 | 353 | 999 | 137 | 3 | 177 | 20,421 | 70 | 6.06 | 1.80 | 3.37 | 0.63 | 16.5 | 4.9 | 1.14 | .281 | 3.56 | 8.49 |
| 7 |  | T. Seaver | 3,279 | 587 | 280 | 181 | .607 | 580 | 2.91 | 200 | 55 | 0 | 4270.0 | 3,531 | 1,380 | 1,520 | 348 | 1,266 | 64 | 4 | 106 | 17,310 | 113 | 6.91 | 2.67 | 2.59 | 0.73 | 18.9 | 7.3 | 1.12 | .258 | 3.20 | 7.44 |
| 8 |  | P. Martinez | 3,154 | 476 | 219 | 100 | .687 | 409 | 2.93 | 46 | 17 | 3 | 2827.1 | 2,221 | 919 | 1,006 | 239 | 760 | 141 | 23 | 30 | 11,394 | 62 | 10.04 | 2.42 | 4.15 | 0.76 | 27.7 | 6.7 | 1.05 | .279 | 3.20 | 7.07 |
| 9 | | C. Schilling | 3,116 | 569 | 216 | 146 | .597 | 436 | 3.46 | 83 | 20 | 22 | 3261.0 | 2,998 | 1,253 | 1,318 | 347 | 711 | 52 | 81 | 43 | 13,284 | 72 | 8.60 | 1.96 | 4.38 | 0.96 | 23.5 | 5.4 | 1.14 | .293 | 3.64 | 8.27 |
| 10 |  | J. Smoltz | 3,084 | 723 | 213 | 155 | .579 | 481 | 3.33 | 53 | 16 | 154 | 3473.0 | 3,074 | 1,284 | 1,391 | 288 | 1,010 | 57 | 204 | 84 | 14,271 | 145 | 7.99 | 2.62 | 3.05 | 0.75 | 21.6 | 7.1 | 1.18 | .283 | 3.60 | 7.97 |
| 11 | | D. Sutton | 3,044 | 667 | 292 | 214 | .577 | 662 | 3.27 | 154 | 51 | 3 | 4632.1 | 4,110 | 1,681 | 1,856 | 429 | 1,179 | 71 | 4 | 74 | 18,969 | 100 | 5.91 | 2.29 | 2.58 | 0.83 | 16.0 | 6.2 | 1.14 | .258 | 3.61 | 7.99 |
| 12 | | P. Niekro | 3,010 | 704 | 289 | 247 | .539 | 663 | 3.45 | 222 | 39 | 10 | 4818.1 | 4,533 | 1,845 | 2,121 | 448 | 1,654 | 105 | 27 | 72 | 20,288 | 180 | 5.62 | 3.09 | 1.82 | 0.84 | 14.8 | 8.2 | 1.28 | .271 | 3.96 | 8.47 |
| 13 | | M. Mussina | 2,813 | 537 | 270 | 153 | .638 | 536 | 3.68 | 57 | 23 | 0 | 3562.2 | 3,460 | 1,458 | 1,559 | 376 | 785 | 60 | 0 | 29 | 14,593 | 71 | 7.11 | 1.98 | 3.58 | 0.95 | 19.3 | 5.4 | 1.19 | .292 | 3.94 | 8.74 |
| 14 | | F. Tanana | 2,773 | 638 | 240 | 236 | .504 | 616 | 3.66 | 143 | 34 | 1 | 4188.1 | 4,063 | 1,702 | 1,910 | 448 | 1,255 | 129 | 10 | 116 | 17,641 | 119 | 5.96 | 2.70 | 2.21 | 0.96 | 15.7 | 7.1 | 1.27 | .277 | 4.10 | 8.73 |
| 15 | | D. Cone | 2,668 | 450 | 194 | 126 | .606 | 419 | 3.47 | 56 | 22 | 1 | 2898.2 | 2,504 | 1,116 | 1,222 | 258 | 1,137 | 106 | 9 | 42 | 12,184 | 149 | 8.28 | 3.53 | 2.35 | 0.80 | 21.9 | 9.3 | 1.26 | .280 | 3.79 | 7.77 |
| 16 | | C. Finley | 2,610 | 524 | 200 | 173 | .536 | 467 | 3.85 | 63 | 15 | 0 | 3197.1 | 3,069 | 1,366 | 1,517 | 304 | 1,332 | 76 | 24 | 36 | 13,638 | 130 | 7.35 | 3.75 | 1.96 | 0.86 | 19.1 | 9.8 | 1.38 | .297 | 4.27 | 8.64 |
| 17 | | T. Glavine | 2,607 | 682 | 305 | 203 | .600 | 682 | 3.54 | 56 | 25 | 0 | 4413.1 | 4,298 | 1,734 | 1,900 | 356 | 1,500 | 66 | 0 | 145 | 18,604 | 65 | 5.32 | 3.06 | 1.74 | 0.73 | 14.0 | 8.1 | 1.31 | .280 | 3.87 | 8.76 |
| 18 | | F. Jenkins | 2,547 | 520 | 238 | 189 | .557 | 506 | 3.44 | 227 | 42 | 1 | 3724.2 | 3,519 | 1,423 | 1,581 | 403 | 798 | 74 | 9 | 90 | 15,290 | 53 | 6.15 | 1.93 | 3.19 | 0.97 | 16.7 | 5.2 | 1.16 | .272 | 3.82 | 8.50 |
| 19 | | G. Perry | 2,545 | 531 | 239 | 196 | .549 | 526 | 3.12 | 243 | 42 | 2 | 4009.2 | 3,739 | 1,389 | 1,611 | 304 | 1,042 | 82 | 5 | 101 | 16,452 | 111 | 5.71 | 2.34 | 2.44 | 0.68 | 15.5 | 6.3 | 1.19 | .275 | 3.62 | 8.39 |
| 20 |  | J. Morris | 2,478 | 549 | 254 | 186 | .577 | 527 | 3.90 | 175 | 28 | 0 | 3824.0 | 3,567 | 1,657 | 1,815 | 389 | 1,390 | 58 | 10 | 99 | 16,120 | 205 | 5.83 | 3.27 | 1.78 | 0.92 | 15.4 | 8.6 | 1.30 | .269 | 4.27 | 8.40 |
| 21 | | M. Langston | 2,464 | 457 | 179 | 158 | .531 | 428 | 3.97 | 81 | 18 | 0 | 2962.2 | 2,723 | 1,306 | 1,438 | 311 | 1,289 | 46 | 3 | 34 | 12,562 | 89 | 7.49 | 3.92 | 1.91 | 0.94 | 19.6 | 10.3 | 1.35 | .285 | 4.37 | 8.27 |
| 22 | | D. Eckersley | 2,401 | 1,071 | 197 | 171 | .535 | 361 | 3.50 | 100 | 20 | 390 | 3285.2 | 3,076 | 1,279 | 1,382 | 347 | 738 | 75 | 577 | 90 | 13,534 | 28 | 6.58 | 2.02 | 3.25 | 0.95 | 17.7 | 5.5 | 1.16 | .274 | 3.79 | 8.43 |
| 23 | | K. Brown | 2,397 | 486 | 211 | 144 | .594 | 476 | 3.28 | 72 | 17 | 0 | 3256.1 | 3,079 | 1,185 | 1,357 | 208 | 901 | 139 | 1 | 42 | 13,542 | 108 | 6.62 | 2.49 | 2.66 | 0.57 | 17.7 | 6.7 | 1.22 | .290 | 3.75 | 8.51 |
| 24 | | J. Koosman | 2,376 | 570 | 204 | 196 | .510 | 492 | 3.44 | 124 | 26 | 17 | 3568.1 | 3,404 | 1,363 | 1,525 | 273 | 1,114 | 64 | 42 | 111 | 14,893 | 81 | 5.99 | 2.81 | 2.13 | 0.69 | 16.0 | 7.5 | 1.27 | .283 | 3.85 | 8.59 |
| 25 | | J. Moyer | 2,372 | 675 | 263 | 198 | .570 | 617 | 4.22 | 32 | 10 | 0 | 3961.0 | 4,099 | 1,857 | 2,000 | 501 | 1,126 | 141 | 15 | 67 | 16,854 | 57 | 5.39 | 2.56 | 2.11 | 1.14 | 14.1 | 6.7 | 1.32 | .283 | 4.54 | 9.31 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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