Between September 24, 1923 and September 29, 1952, Bob Feller fanned the most batters, with 2,419 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | B. Feller | 2,419 | 482 | 239 | 144 | .624 | 425 | 3.21 | 256 | 41 | 20 | 3370.1 | 2,847 | 1,203 | 1,349 | 180 | 1,611 | 53 | 43 | 14,277 | 68 | 6.46 | 4.30 | 1.50 | 0.48 | 16.9 | 11.3 | 1.32 | .266 | 3.60 | 7.60 | |
| 2 | | L. Grove | 2,269 | 616 | 300 | 141 | .680 | 457 | 3.06 | 298 | 35 | 54 | 3938.1 | 3,848 | 1,341 | 1,596 | 162 | 1,184 | 41 | 123 | 16,622 | 51 | 5.19 | 2.71 | 1.92 | 0.37 | 13.7 | 7.1 | 1.28 | .284 | 3.65 | 8.79 | |
| 3 | | B. Newsom | 2,065 | 583 | 209 | 221 | .486 | 481 | 3.97 | 245 | 31 | 21 | 3720.2 | 3,724 | 1,643 | 1,884 | 204 | 1,710 | 56 | 62 | 16,295 | 60 | 5.00 | 4.14 | 1.21 | 0.49 | 12.7 | 10.5 | 1.46 | .287 | 4.56 | 9.01 | |
| 4 | | R. Ruffing | 1,990 | 624 | 273 | 225 | .548 | 538 | 3.80 | 335 | 45 | 18 | 4341.1 | 4,288 | 1,835 | 2,117 | 254 | 1,542 | 57 | 69 | 18,525 | 46 | 4.13 | 3.20 | 1.29 | 0.53 | 10.7 | 8.3 | 1.34 | .275 | 4.39 | 8.89 | |
| 5 | | H. Newhouser | 1,763 | 453 | 200 | 147 | .576 | 369 | 3.04 | 212 | 33 | 18 | 2922.1 | 2,609 | 986 | 1,159 | 130 | 1,218 | 17 | 63 | 12,342 | 63 | 5.43 | 3.75 | 1.45 | 0.40 | 14.3 | 9.9 | 1.31 | .269 | 3.57 | 8.04 | |
| 6 | | D. Vance | 1,715 | 361 | 161 | 111 | .592 | 282 | 3.16 | 179 | 21 | 12 | 2427.2 | 2,272 | 853 | 991 | 115 | 628 | 56 | 42 | 10,048 | 27 | 6.36 | 2.33 | 2.73 | 0.43 | 17.1 | 6.3 | 1.19 | .286 | 3.67 | 8.42 | |
| 7 | | T. Bridges | 1,681 | 424 | 194 | 138 | .584 | 362 | 3.57 | 200 | 33 | 10 | 2825.2 | 2,674 | 1,122 | 1,322 | 179 | 1,193 | 35 | 47 | 12,163 | 59 | 5.35 | 3.80 | 1.41 | 0.57 | 13.8 | 9.8 | 1.37 | .275 | 4.21 | 8.52 | |
| 8 | | C. Hubbell | 1,678 | 535 | 253 | 154 | .622 | 433 | 2.98 | 260 | 36 | 33 | 3588.2 | 3,462 | 1,188 | 1,384 | 227 | 728 | 53 | 82 | 14,810 | 53 | 4.21 | 1.83 | 2.30 | 0.57 | 11.3 | 4.9 | 1.17 | .267 | 3.47 | 8.68 | |
| 9 | | P. Derringer | 1,509 | 579 | 223 | 212 | .513 | 445 | 3.46 | 251 | 32 | 29 | 3643.0 | 3,911 | 1,401 | 1,653 | 159 | 765 | 32 | 98 | 15,404 | 50 | 3.73 | 1.89 | 1.97 | 0.39 | 9.8 | 5.0 | 1.28 | .290 | 4.08 | 9.66 | |
| 10 | | L. Gomez | 1,468 | 368 | 189 | 102 | .649 | 320 | 3.34 | 173 | 28 | 10 | 2502.0 | 2,289 | 929 | 1,090 | 139 | 1,095 | 21 | 31 | 10,712 | 39 | 5.28 | 3.94 | 1.34 | 0.50 | 13.7 | 10.2 | 1.35 | .269 | 3.92 | 8.23 | |
| 11 | | C. Root | 1,436 | 610 | 201 | 157 | .561 | 339 | 3.56 | 177 | 21 | 42 | 3146.0 | 3,194 | 1,244 | 1,430 | 187 | 873 | 74 | 175 | 13,299 | 21 | 4.11 | 2.50 | 1.64 | 0.53 | 10.8 | 6.6 | 1.29 | .280 | 4.09 | 9.14 | |
| 12 | | E. Whitehill | 1,347 | 537 | 218 | 185 | .541 | 473 | 4.36 | 226 | 16 | 11 | 3558.0 | 3,910 | 1,723 | 2,013 | 192 | 1,424 | 102 | 45 | 15,742 | 43 | 3.41 | 3.60 | 0.95 | 0.49 | 8.6 | 9.0 | 1.50 | .293 | 5.09 | 9.89 | |
| 13 | | B. Hadley | 1,316 | 528 | 161 | 165 | .494 | 355 | 4.24 | 134 | 14 | 25 | 2945.0 | 2,978 | 1,389 | 1,610 | 167 | 1,446 | 63 | 108 | 13,012 | 72 | 4.02 | 4.42 | 0.91 | 0.51 | 10.1 | 11.1 | 1.50 | .281 | 4.92 | 9.10 | |
| 14 | | J. Vander Meer | 1,303 | 346 | 119 | 121 | .496 | 286 | 3.44 | 131 | 29 | 2 | 2103.2 | 1,800 | 804 | 915 | 99 | 1,132 | 23 | 28 | 9,061 | 37 | 5.57 | 4.84 | 1.15 | 0.42 | 14.4 | 12.5 | 1.39 | .262 | 3.91 | 7.70 | |
| 15 | | D. Trout | 1,256 | 519 | 170 | 161 | .514 | 322 | 3.25 | 158 | 28 | 37 | 2725.1 | 2,637 | 983 | 1,166 | 112 | 1,047 | 34 | 133 | 11,607 | 50 | 4.15 | 3.46 | 1.20 | 0.37 | 10.8 | 9.0 | 1.35 | .276 | 3.85 | 8.71 | |
| 16 | | V. Mungo | 1,245 | 364 | 120 | 115 | .511 | 259 | 3.48 | 123 | 20 | 16 | 2110.2 | 1,954 | 815 | 958 | 89 | 874 | 33 | 61 | 9,031 | 52 | 5.31 | 3.73 | 1.42 | 0.38 | 13.8 | 9.7 | 1.34 | .275 | 4.08 | 8.33 | |
| 17 | | A. Reynolds | 1,237 | 357 | 156 | 96 | .619 | 276 | 3.29 | 127 | 31 | 28 | 2189.2 | 1,920 | 800 | 897 | 111 | 1,134 | 48 | 60 | 9,375 | 49 | 5.08 | 4.66 | 1.09 | 0.46 | 13.2 | 12.1 | 1.39 | .264 | 3.69 | 7.89 | |
| 18 | | L. French | 1,186 | 570 | 197 | 171 | .535 | 383 | 3.45 | 199 | 40 | 17 | 3150.1 | 3,372 | 1,207 | 1,441 | 163 | 822 | 42 | 108 | 13,458 | 34 | 3.39 | 2.35 | 1.44 | 0.47 | 8.8 | 6.1 | 1.33 | .285 | 4.12 | 9.63 | |
| 19 | | D. Dean | 1,163 | 317 | 150 | 83 | .644 | 230 | 3.02 | 154 | 26 | 31 | 1968.2 | 1,920 | 661 | 774 | 93 | 451 | 27 | 77 | 8,176 | 12 | 5.32 | 2.06 | 2.58 | 0.43 | 14.2 | 5.5 | 1.20 | .284 | 3.54 | 8.78 | |
| 20 | | M. Harder | 1,162 | 582 | 223 | 186 | .545 | 433 | 3.80 | 181 | 25 | 24 | 3425.1 | 3,706 | 1,447 | 1,714 | 159 | 1,118 | 59 | 94 | 14,862 | 33 | 3.05 | 2.94 | 1.04 | 0.42 | 7.8 | 7.5 | 1.41 | .287 | 4.50 | 9.74 | |
| 21 | | L. Warneke | 1,145 | 445 | 192 | 121 | .613 | 343 | 3.19 | 192 | 30 | 14 | 2780.2 | 2,729 | 987 | 1,167 | 174 | 740 | 27 | 66 | 11,610 | 50 | 3.71 | 2.40 | 1.55 | 0.56 | 9.9 | 6.4 | 1.25 | .268 | 3.78 | 8.83 | |
| 22 | | D. Leonard | 1,143 | 595 | 189 | 178 | .515 | 375 | 3.24 | 192 | 30 | 36 | 3156.0 | 3,236 | 1,136 | 1,398 | 149 | 712 | 55 | 144 | 13,258 | 96 | 3.26 | 2.03 | 1.61 | 0.42 | 8.6 | 5.4 | 1.25 | .276 | 3.99 | 9.23 | |
| 23 | | B. Walters | 1,111 | 428 | 198 | 160 | .553 | 398 | 3.30 | 242 | 42 | 4 | 3103.2 | 2,991 | 1,139 | 1,343 | 153 | 1,122 | 52 | 18 | 13,156 | 63 | 3.22 | 3.25 | 0.99 | 0.44 | 8.4 | 8.5 | 1.33 | .265 | 3.89 | 8.67 | |
| 24 | | C. Passeau | 1,104 | 444 | 162 | 150 | .519 | 331 | 3.32 | 188 | 26 | 21 | 2719.0 | 2,856 | 1,003 | 1,203 | 106 | 731 | 40 | 85 | 11,645 | 22 | 3.65 | 2.42 | 1.51 | 0.35 | 9.5 | 6.3 | 1.32 | .285 | 3.98 | 9.45 | |
| 25 | | J. Allen | 1,072 | 352 | 142 | 75 | .654 | 241 | 3.76 | 109 | 17 | 16 | 1950.1 | 1,850 | 814 | 927 | 103 | 738 | 38 | 68 | 8,296 | 68 | 4.95 | 3.41 | 1.45 | 0.48 | 12.9 | 8.9 | 1.33 | .275 | 4.28 | 8.54 | |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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