Between April 24, 1948 and October 2, 1968, Jim Bunning struck out the most hitters, with 2,493 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | J. Bunning | 2,493 | 494 | 196 | 147 | .571 | 436 | 3.11 | 141 | 40 | 15 | 3218.2 | 2,862 | 1,111 | 1,247 | 327 | 848 | 139 | 31 | 78 | 13,302 | 41 | 6.97 | 2.37 | 2.94 | 0.91 | 18.7 | 6.4 | 1.15 | .267 | 3.49 | 8.00 |
| 2 | | D. Drysdale | 2,462 | 506 | 204 | 162 | .557 | 453 | 2.92 | 166 | 48 | 6 | 3369.1 | 3,013 | 1,093 | 1,258 | 271 | 842 | 152 | 34 | 123 | 13,830 | 81 | 6.58 | 2.25 | 2.92 | 0.72 | 17.8 | 6.1 | 1.14 | .271 | 3.36 | 8.05 |
| 3 |  | S. Koufax | 2,396 | 397 | 165 | 87 | .655 | 314 | 2.76 | 137 | 40 | 9 | 2324.1 | 1,754 | 713 | 806 | 204 | 817 | 18 | 44 | 48 | 9,497 | 87 | 9.28 | 3.16 | 2.93 | 0.79 | 25.2 | 8.6 | 1.11 | .256 | 3.12 | 6.79 |
| 4 | | W. Spahn | 2,384 | 681 | 334 | 229 | .593 | 611 | 3.13 | 351 | 56 | 24 | 4805.2 | 4,449 | 1,672 | 1,866 | 412 | 1,301 | 39 | 56 | 19,759 | 69 | 4.46 | 2.44 | 1.83 | 0.77 | 12.1 | 6.6 | 1.20 | .258 | 3.49 | 8.33 | |
| 5 | | R. Roberts | 2,362 | 676 | 286 | 245 | .539 | 609 | 3.40 | 305 | 45 | 25 | 4688.2 | 4,582 | 1,773 | 1,962 | 505 | 901 | 54 | 49 | 19,222 | 34 | 4.53 | 1.73 | 2.62 | 0.97 | 12.3 | 4.7 | 1.17 | .265 | 3.77 | 8.80 | |
| 6 | | C. Pascual | 2,103 | 491 | 170 | 163 | .511 | 389 | 3.56 | 132 | 36 | 10 | 2830.2 | 2,612 | 1,121 | 1,271 | 240 | 1,011 | 54 | 61 | 11,977 | 82 | 6.69 | 3.21 | 2.08 | 0.76 | 17.6 | 8.4 | 1.28 | .277 | 4.04 | 8.30 | |
| 7 | | E. Wynn | 1,999 | 532 | 236 | 175 | .574 | 473 | 3.50 | 212 | 41 | 13 | 3487.0 | 3,153 | 1,357 | 1,514 | 291 | 1,407 | 50 | 47 | 14,756 | 37 | 5.16 | 3.63 | 1.42 | 0.75 | 13.5 | 9.5 | 1.31 | .260 | 3.91 | 8.14 | |
| 8 | | B. Pierce | 1,988 | 580 | 211 | 169 | .555 | 433 | 3.27 | 193 | 38 | 33 | 3296.2 | 2,983 | 1,196 | 1,322 | 283 | 1,169 | 29 | 81 | 13,806 | 48 | 5.43 | 3.19 | 1.70 | 0.77 | 14.4 | 8.5 | 1.26 | .261 | 3.61 | 8.14 | |
| 9 | | W. Ford | 1,959 | 498 | 236 | 106 | .690 | 438 | 2.75 | 156 | 45 | 11 | 3170.1 | 2,766 | 968 | 1,107 | 228 | 1,086 | 28 | 35 | 13,031 | 75 | 5.56 | 3.08 | 1.80 | 0.65 | 15.0 | 8.3 | 1.22 | .261 | 3.14 | 7.85 | |
| 10 |  | B. Gibson | 1,850 | 314 | 147 | 97 | .602 | 276 | 2.84 | 138 | 38 | 4 | 2208.2 | 1,810 | 698 | 798 | 158 | 766 | 66 | 17 | 54 | 9,109 | 66 | 7.54 | 3.12 | 2.42 | 0.64 | 20.3 | 8.4 | 1.17 | .264 | 3.25 | 7.38 |
| 11 | | B. Friend | 1,734 | 602 | 197 | 230 | .461 | 497 | 3.58 | 163 | 36 | 10 | 3610.2 | 3,771 | 1,436 | 1,652 | 286 | 894 | 46 | 56 | 114 | 15,216 | 50 | 4.32 | 2.23 | 1.94 | 0.71 | 11.4 | 5.9 | 1.29 | .284 | 4.12 | 9.40 |
| 12 | | L. Jackson | 1,710 | 558 | 194 | 183 | .515 | 429 | 3.40 | 149 | 37 | 21 | 3262.2 | 3,206 | 1,234 | 1,406 | 259 | 823 | 68 | 73 | 106 | 13,594 | 58 | 4.72 | 2.27 | 2.08 | 0.71 | 12.6 | 6.1 | 1.23 | .275 | 3.88 | 8.84 |
| 13 | | C. Simmons | 1,689 | 567 | 192 | 182 | .513 | 460 | 3.54 | 162 | 36 | 5 | 3337.2 | 3,309 | 1,313 | 1,546 | 255 | 1,052 | 52 | 54 | 14,152 | 41 | 4.55 | 2.84 | 1.61 | 0.69 | 11.9 | 7.4 | 1.31 | .275 | 4.17 | 8.92 | |
| 14 | | J. Marichal | 1,634 | 291 | 170 | 77 | .688 | 284 | 2.63 | 170 | 37 | 2 | 2250.0 | 1,917 | 658 | 771 | 208 | 449 | 24 | 7 | 50 | 9,037 | 32 | 6.54 | 1.80 | 3.64 | 0.83 | 18.1 | 5.0 | 1.05 | .254 | 3.08 | 7.67 |
| 15 | | H. Haddix | 1,576 | 453 | 136 | 113 | .546 | 286 | 3.63 | 99 | 20 | 20 | 2235.0 | 2,154 | 901 | 1,012 | 240 | 600 | 43 | 84 | 9,330 | 57 | 6.35 | 2.42 | 2.63 | 0.97 | 16.9 | 6.4 | 1.23 | .279 | 4.08 | 8.67 | |
| 16 | | J. Maloney | 1,483 | 252 | 122 | 75 | .619 | 228 | 3.12 | 68 | 27 | 3 | 1623.1 | 1,322 | 562 | 625 | 121 | 685 | 32 | 10 | 31 | 6,760 | 105 | 8.22 | 3.80 | 2.16 | 0.67 | 21.9 | 10.1 | 1.24 | .271 | 3.47 | 7.33 |
| 17 | | H. Wilhelm | 1,453 | 937 | 130 | 108 | .546 | 52 | 2.47 | 20 | 5 | 197 | 2050.1 | 1,601 | 563 | 694 | 135 | 692 | 57 | 554 | 52 | 8,329 | 78 | 6.38 | 3.04 | 2.10 | 0.59 | 17.4 | 8.3 | 1.12 | .245 | 3.05 | 7.03 |
| 18 | | J. Podres | 1,418 | 423 | 143 | 110 | .565 | 331 | 3.66 | 76 | 24 | 10 | 2200.1 | 2,173 | 894 | 992 | 235 | 715 | 27 | 44 | 9,284 | 64 | 5.80 | 2.92 | 1.98 | 0.96 | 15.3 | 7.7 | 1.31 | .281 | 4.06 | 8.89 | |
| 19 | | S. McDowell | 1,384 | 223 | 71 | 66 | .518 | 187 | 2.96 | 52 | 15 | 9 | 1305.0 | 985 | 429 | 497 | 78 | 686 | 36 | 18 | 28 | 5,524 | 70 | 9.54 | 4.73 | 2.02 | 0.54 | 25.1 | 12.4 | 1.28 | .272 | 3.43 | 6.79 |
| 20 | | S. Jones | 1,378 | 322 | 102 | 101 | .502 | 222 | 3.59 | 76 | 17 | 10 | 1643.1 | 1,401 | 655 | 752 | 151 | 822 | 60 | 45 | 37 | 7,073 | 45 | 7.55 | 4.50 | 1.68 | 0.83 | 19.5 | 11.6 | 1.35 | .268 | 4.12 | 7.67 |
| 21 | | J. Nuxhall | 1,376 | 525 | 135 | 117 | .536 | 287 | 3.88 | 83 | 20 | 19 | 2301.2 | 2,308 | 992 | 1,088 | 209 | 771 | 70 | 100 | 9,802 | 42 | 5.38 | 3.01 | 1.78 | 0.82 | 14.0 | 7.9 | 1.34 | .285 | 4.25 | 9.02 | |
| 22 | | J. Pizarro | 1,345 | 363 | 113 | 85 | .571 | 217 | 3.37 | 71 | 14 | 19 | 1707.1 | 1,509 | 639 | 734 | 169 | 726 | 33 | 76 | 47 | 7,269 | 57 | 7.09 | 3.83 | 1.85 | 0.89 | 18.5 | 10.0 | 1.31 | .268 | 3.87 | 7.95 |
| 23 | | C. Short | 1,332 | 371 | 115 | 96 | .545 | 239 | 3.20 | 76 | 20 | 13 | 1848.0 | 1,701 | 658 | 744 | 138 | 621 | 49 | 57 | 59 | 7,713 | 61 | 6.49 | 3.02 | 2.14 | 0.67 | 17.3 | 8.1 | 1.26 | .280 | 3.62 | 8.28 |
| 24 | | M. Pappas | 1,326 | 368 | 150 | 111 | .575 | 326 | 3.37 | 96 | 32 | 4 | 2243.1 | 2,060 | 839 | 924 | 201 | 640 | 49 | 28 | 51 | 9,243 | 79 | 5.32 | 2.57 | 2.07 | 0.81 | 14.3 | 6.9 | 1.20 | .265 | 3.71 | 8.26 |
| 25 | | G. Bell | 1,322 | 483 | 119 | 111 | .517 | 220 | 3.59 | 70 | 8 | 48 | 1915.0 | 1,670 | 764 | 865 | 191 | 785 | 50 | 151 | 53 | 8,085 | 62 | 6.21 | 3.69 | 1.68 | 0.90 | 16.4 | 9.7 | 1.28 | .258 | 4.07 | 7.85 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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