Between July 3, 1982 and April 20, 2008, Roger Clemens struck out the most hitters, with 4,672 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Clemens | 4,672 | 709 | 354 | 184 | .658 | 707 | 3.12 | 118 | 46 | 0 | 4916.2 | 4,185 | 1,707 | 1,885 | 363 | 1,580 | 159 | 0 | 63 | 20,240 | 143 | 8.55 | 2.89 | 2.96 | 0.66 | 23.1 | 7.8 | 1.17 | .284 | 3.45 | 7.66 |
| 2 |  | R. Johnson | 4,629 | 568 | 284 | 151 | .653 | 558 | 3.22 | 98 | 37 | 2 | 3866.0 | 3,074 | 1,385 | 1,565 | 369 | 1,429 | 183 | 5 | 29 | 15,927 | 102 | 10.78 | 3.33 | 3.24 | 0.86 | 29.1 | 9.0 | 1.16 | .290 | 3.64 | 7.16 |
| 3 |  | G. Maddux | 3,287 | 715 | 349 | 215 | .619 | 711 | 3.12 | 109 | 35 | 0 | 4839.1 | 4,546 | 1,678 | 1,890 | 336 | 975 | 131 | 3 | 173 | 19,722 | 68 | 6.11 | 1.81 | 3.37 | 0.62 | 16.7 | 4.9 | 1.14 | .281 | 3.51 | 8.45 |
| 4 |  | C. Schilling | 3,116 | 569 | 216 | 146 | .597 | 436 | 3.46 | 83 | 20 | 22 | 3261.0 | 2,998 | 1,253 | 1,318 | 347 | 711 | 52 | 81 | 43 | 13,284 | 72 | 8.60 | 1.96 | 4.38 | 0.96 | 23.5 | 5.4 | 1.14 | .293 | 3.64 | 8.27 |
| 5 |  | P. Martinez | 3,031 | 448 | 209 | 93 | .692 | 381 | 2.81 | 46 | 17 | 3 | 2677.0 | 2,050 | 837 | 922 | 215 | 709 | 132 | 23 | 27 | 10,726 | 60 | 10.19 | 2.38 | 4.28 | 0.72 | 28.3 | 6.6 | 1.03 | .276 | 3.10 | 6.89 |
| 6 |  | J. Smoltz | 2,996 | 705 | 210 | 145 | .592 | 464 | 3.25 | 53 | 16 | 154 | 3383.0 | 2,964 | 1,222 | 1,329 | 275 | 990 | 54 | 204 | 82 | 13,873 | 144 | 7.97 | 2.63 | 3.03 | 0.73 | 21.6 | 7.1 | 1.17 | .281 | 3.54 | 7.89 |
| 7 | | M. Mussina | 2,670 | 507 | 251 | 147 | .631 | 506 | 3.71 | 57 | 23 | 0 | 3382.2 | 3,271 | 1,396 | 1,488 | 364 | 757 | 55 | 0 | 26 | 13,860 | 67 | 7.10 | 2.01 | 3.53 | 0.97 | 19.3 | 5.5 | 1.19 | .290 | 3.96 | 8.70 |
| 8 | | D. Cone | 2,668 | 450 | 194 | 126 | .606 | 419 | 3.47 | 56 | 22 | 1 | 2898.2 | 2,504 | 1,116 | 1,222 | 258 | 1,137 | 106 | 9 | 42 | 12,184 | 149 | 8.28 | 3.53 | 2.35 | 0.80 | 21.9 | 9.3 | 1.26 | .280 | 3.79 | 7.77 |
| 9 | | C. Finley | 2,610 | 524 | 200 | 173 | .536 | 467 | 3.85 | 63 | 15 | 0 | 3197.1 | 3,069 | 1,366 | 1,517 | 304 | 1,332 | 76 | 24 | 36 | 13,638 | 130 | 7.35 | 3.75 | 1.96 | 0.86 | 19.1 | 9.8 | 1.38 | .297 | 4.27 | 8.64 |
| 10 | | T. Glavine | 2,576 | 672 | 303 | 200 | .602 | 672 | 3.50 | 56 | 25 | 0 | 4361.1 | 4,244 | 1,698 | 1,864 | 345 | 1,469 | 65 | 0 | 141 | 18,373 | 65 | 5.32 | 3.03 | 1.75 | 0.71 | 14.0 | 8.0 | 1.31 | .280 | 3.85 | 8.76 |
| 11 | | M. Langston | 2,464 | 457 | 179 | 158 | .531 | 428 | 3.97 | 81 | 18 | 0 | 2962.2 | 2,723 | 1,306 | 1,438 | 311 | 1,289 | 46 | 3 | 34 | 12,562 | 89 | 7.49 | 3.92 | 1.91 | 0.94 | 19.6 | 10.3 | 1.35 | .285 | 4.37 | 8.27 |
| 12 | | K. Brown | 2,397 | 486 | 211 | 144 | .594 | 476 | 3.28 | 72 | 17 | 0 | 3256.1 | 3,079 | 1,185 | 1,357 | 208 | 901 | 139 | 1 | 42 | 13,542 | 108 | 6.62 | 2.49 | 2.66 | 0.57 | 17.7 | 6.7 | 1.22 | .290 | 3.75 | 8.51 |
| 13 |  | N. Ryan | 2,361 | 338 | 128 | 110 | .538 | 338 | 3.24 | 42 | 14 | 0 | 2203.1 | 1,624 | 794 | 905 | 151 | 937 | 73 | 0 | 33 | 9,110 | 120 | 9.64 | 3.83 | 2.52 | 0.62 | 25.9 | 10.3 | 1.16 | .264 | 3.70 | 6.63 |
| 14 | | D. Gooden | 2,293 | 430 | 194 | 112 | .634 | 410 | 3.51 | 68 | 24 | 3 | 2800.2 | 2,564 | 1,091 | 1,198 | 210 | 954 | 78 | 4 | 42 | 11,705 | 76 | 7.37 | 3.07 | 2.40 | 0.67 | 19.6 | 8.2 | 1.26 | .288 | 3.85 | 8.24 |
| 15 | | D. Wells | 2,201 | 660 | 239 | 157 | .604 | 489 | 4.13 | 54 | 12 | 13 | 3439.0 | 3,635 | 1,578 | 1,702 | 407 | 719 | 83 | 65 | 65 | 14,413 | 101 | 5.76 | 1.88 | 3.06 | 1.07 | 15.3 | 5.0 | 1.27 | .293 | 4.45 | 9.51 |
| 16 | | J. Moyer | 2,132 | 608 | 231 | 179 | .563 | 555 | 4.22 | 31 | 9 | 0 | 3571.0 | 3,706 | 1,673 | 1,810 | 446 | 1,018 | 118 | 14 | 64 | 15,198 | 53 | 5.37 | 2.57 | 2.09 | 1.12 | 14.0 | 6.7 | 1.32 | .284 | 4.56 | 9.34 |
| 17 |  | J. Morris | 2,017 | 407 | 195 | 142 | .579 | 407 | 3.94 | 131 | 24 | 0 | 2903.2 | 2,719 | 1,271 | 1,398 | 305 | 1,046 | 45 | 0 | 71 | 12,263 | 178 | 6.25 | 3.24 | 1.93 | 0.95 | 16.4 | 8.5 | 1.30 | .273 | 4.33 | 8.43 |
| 18 | | O. Hershiser | 2,014 | 510 | 204 | 150 | .576 | 466 | 3.48 | 68 | 25 | 5 | 3130.1 | 2,939 | 1,211 | 1,367 | 235 | 1,007 | 117 | 19 | 108 | 13,150 | 121 | 5.79 | 2.90 | 2.00 | 0.68 | 15.3 | 7.7 | 1.26 | .277 | 3.93 | 8.45 |
| 19 | | A. Benes | 2,000 | 403 | 155 | 139 | .527 | 387 | 3.97 | 21 | 9 | 1 | 2505.1 | 2,377 | 1,106 | 1,206 | 289 | 909 | 55 | 6 | 52 | 10,645 | 63 | 7.18 | 3.27 | 2.20 | 1.04 | 18.8 | 8.5 | 1.31 | .282 | 4.33 | 8.54 |
| 20 | | K. Appier | 1,994 | 414 | 169 | 137 | .552 | 402 | 3.74 | 34 | 12 | 0 | 2595.1 | 2,425 | 1,078 | 1,168 | 232 | 933 | 79 | 2 | 51 | 10,958 | 106 | 6.91 | 3.24 | 2.14 | 0.80 | 18.2 | 8.5 | 1.29 | .284 | 4.05 | 8.41 |
| 21 | | A. Leiter | 1,974 | 419 | 162 | 132 | .551 | 382 | 3.80 | 16 | 10 | 2 | 2391.0 | 2,152 | 1,010 | 1,101 | 198 | 1,163 | 117 | 9 | 53 | 10,334 | 63 | 7.43 | 4.38 | 1.70 | 0.75 | 19.1 | 11.3 | 1.39 | .284 | 4.14 | 8.10 |
| 22 | | B. Witt | 1,955 | 430 | 142 | 157 | .475 | 397 | 4.83 | 47 | 11 | 0 | 2465.0 | 2,493 | 1,324 | 1,449 | 252 | 1,375 | 39 | 13 | 37 | 11,003 | 128 | 7.14 | 5.02 | 1.42 | 0.92 | 17.8 | 12.5 | 1.57 | .304 | 5.29 | 9.10 |
| 23 | | H. Nomo | 1,918 | 323 | 123 | 109 | .530 | 318 | 4.24 | 16 | 9 | 0 | 1976.1 | 1,768 | 932 | 993 | 251 | 908 | 38 | 2 | 31 | 8,462 | 110 | 8.73 | 4.13 | 2.11 | 1.14 | 22.7 | 10.7 | 1.35 | .284 | 4.52 | 8.05 |
| 24 | | T. Gordon | 1,910 | 861 | 133 | 123 | .520 | 203 | 3.94 | 18 | 4 | 157 | 2083.1 | 1,864 | 913 | 1,000 | 173 | 961 | 38 | 341 | 56 | 8,942 | 106 | 8.25 | 4.15 | 1.99 | 0.75 | 21.4 | 10.7 | 1.36 | .289 | 4.32 | 8.05 |
| 25 | | K. Rogers | 1,895 | 736 | 211 | 146 | .591 | 448 | 4.21 | 36 | 9 | 28 | 3150.1 | 3,268 | 1,473 | 1,637 | 319 | 1,116 | 119 | 133 | 50 | 13,595 | 77 | 5.41 | 3.19 | 1.70 | 0.91 | 13.9 | 8.2 | 1.39 | .291 | 4.68 | 9.34 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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