Between July 31, 1978 and April 28, 2003, Roger Clemens struck out the most batters, with 3,940 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Clemens | 3,940 | 579 | 297 | 151 | .663 | 578 | 3.14 | 116 | 45 | 0 | 4101.0 | 3,505 | 1,433 | 1,581 | 298 | 1,331 | 137 | 0 | 51 | 16,910 | 121 | 8.65 | 2.92 | 2.96 | 0.65 | 23.3 | 7.9 | 1.18 | .286 | 3.47 | 7.69 |
| 2 |  | R. Johnson | 3,777 | 440 | 225 | 108 | .676 | 430 | 3.09 | 87 | 34 | 2 | 3031.2 | 2,340 | 1,041 | 1,174 | 270 | 1,236 | 141 | 5 | 19 | 12,514 | 91 | 11.21 | 3.67 | 3.06 | 0.80 | 30.2 | 9.9 | 1.18 | .292 | 3.49 | 6.95 |
| 3 |  | N. Ryan | 3,132 | 457 | 178 | 151 | .541 | 457 | 3.24 | 77 | 24 | 0 | 3009.1 | 2,274 | 1,082 | 1,239 | 190 | 1,318 | 86 | 0 | 43 | 12,506 | 166 | 9.37 | 3.94 | 2.38 | 0.57 | 25.0 | 10.5 | 1.19 | .268 | 3.71 | 6.80 |
| 4 |  | D. Cone | 2,668 | 449 | 194 | 126 | .606 | 419 | 3.46 | 56 | 22 | 1 | 2896.2 | 2,503 | 1,115 | 1,221 | 257 | 1,135 | 106 | 9 | 42 | 12,176 | 149 | 8.29 | 3.53 | 2.35 | 0.80 | 21.9 | 9.3 | 1.26 | .280 | 3.79 | 7.78 |
| 5 |  | G. Maddux | 2,661 | 545 | 275 | 155 | .640 | 541 | 2.86 | 102 | 34 | 0 | 3783.2 | 3,442 | 1,201 | 1,377 | 217 | 812 | 102 | 3 | 151 | 15,370 | 50 | 6.33 | 1.93 | 3.28 | 0.52 | 17.3 | 5.3 | 1.12 | .279 | 3.28 | 8.19 |
| 6 | | C. Finley | 2,610 | 524 | 200 | 173 | .536 | 467 | 3.85 | 63 | 15 | 0 | 3197.1 | 3,069 | 1,366 | 1,517 | 304 | 1,332 | 76 | 24 | 36 | 13,638 | 130 | 7.35 | 3.75 | 1.96 | 0.86 | 19.1 | 9.8 | 1.38 | .297 | 4.27 | 8.64 |
| 7 | | M. Langston | 2,464 | 457 | 179 | 158 | .531 | 428 | 3.97 | 81 | 18 | 0 | 2962.2 | 2,723 | 1,306 | 1,438 | 311 | 1,289 | 46 | 3 | 34 | 12,562 | 89 | 7.49 | 3.92 | 1.91 | 0.94 | 19.6 | 10.3 | 1.35 | .285 | 4.37 | 8.27 |
| 8 |  | J. Morris | 2,420 | 524 | 251 | 181 | .581 | 516 | 3.89 | 174 | 28 | 0 | 3710.2 | 3,463 | 1,605 | 1,760 | 380 | 1,339 | 56 | 2 | 97 | 15,639 | 201 | 5.87 | 3.25 | 1.81 | 0.92 | 15.5 | 8.6 | 1.29 | .269 | 4.27 | 8.40 |
| 9 | | C. Schilling | 2,380 | 430 | 156 | 110 | .586 | 318 | 3.37 | 77 | 17 | 13 | 2445.1 | 2,161 | 915 | 973 | 249 | 580 | 37 | 60 | 39 | 9,926 | 65 | 8.76 | 2.13 | 4.10 | 0.92 | 24.0 | 5.8 | 1.12 | .286 | 3.58 | 7.95 |
| 10 | | D. Gooden | 2,293 | 430 | 194 | 112 | .634 | 410 | 3.51 | 68 | 24 | 3 | 2800.2 | 2,564 | 1,091 | 1,198 | 210 | 954 | 78 | 4 | 42 | 11,705 | 76 | 7.37 | 3.07 | 2.40 | 0.67 | 19.6 | 8.2 | 1.26 | .288 | 3.85 | 8.24 |
| 11 |  | P. Martinez | 2,258 | 332 | 154 | 64 | .706 | 265 | 2.63 | 38 | 15 | 3 | 1932.2 | 1,433 | 564 | 630 | 144 | 522 | 92 | 23 | 21 | 7,697 | 47 | 10.52 | 2.43 | 4.33 | 0.67 | 29.3 | 6.8 | 1.01 | .275 | 2.93 | 6.67 |
| 12 |  | J. Smoltz | 2,257 | 478 | 163 | 118 | .580 | 361 | 3.33 | 47 | 14 | 74 | 2566.1 | 2,213 | 949 | 1,040 | 206 | 809 | 40 | 99 | 58 | 10,546 | 121 | 7.92 | 2.84 | 2.79 | 0.72 | 21.4 | 7.7 | 1.18 | .277 | 3.65 | 7.76 |
| 13 | | K. Brown | 2,105 | 424 | 184 | 123 | .599 | 414 | 3.22 | 72 | 17 | 0 | 2869.1 | 2,682 | 1,028 | 1,180 | 180 | 802 | 124 | 1 | 39 | 11,915 | 91 | 6.60 | 2.52 | 2.62 | 0.56 | 17.7 | 6.7 | 1.21 | .287 | 3.70 | 8.41 |
| 14 | | F. Valenzuela | 2,074 | 453 | 173 | 153 | .531 | 424 | 3.54 | 113 | 31 | 2 | 2930.0 | 2,718 | 1,154 | 1,303 | 226 | 1,151 | 25 | 10 | 65 | 12,398 | 119 | 6.37 | 3.54 | 1.80 | 0.69 | 16.7 | 9.3 | 1.32 | .279 | 4.00 | 8.35 |
| 15 | | T. Glavine | 2,073 | 511 | 245 | 145 | .628 | 511 | 3.37 | 52 | 22 | 0 | 3379.2 | 3,210 | 1,266 | 1,404 | 249 | 1,153 | 50 | 0 | 112 | 14,178 | 60 | 5.52 | 3.07 | 1.80 | 0.66 | 14.6 | 8.1 | 1.29 | .278 | 3.74 | 8.55 |
| 16 | | O. Hershiser | 2,014 | 510 | 204 | 150 | .576 | 466 | 3.48 | 68 | 25 | 5 | 3130.1 | 2,939 | 1,211 | 1,367 | 235 | 1,007 | 117 | 19 | 108 | 13,150 | 121 | 5.79 | 2.90 | 2.00 | 0.68 | 15.3 | 7.7 | 1.26 | .277 | 3.93 | 8.45 |
| 17 | | A. Benes | 2,000 | 403 | 155 | 139 | .527 | 387 | 3.97 | 21 | 9 | 1 | 2505.1 | 2,377 | 1,106 | 1,206 | 289 | 909 | 55 | 6 | 52 | 10,645 | 63 | 7.18 | 3.27 | 2.20 | 1.04 | 18.8 | 8.5 | 1.31 | .282 | 4.33 | 8.54 |
| 18 | | M. Mussina | 1,973 | 360 | 187 | 102 | .647 | 360 | 3.52 | 51 | 20 | 0 | 2491.0 | 2,331 | 973 | 1,034 | 258 | 565 | 31 | 0 | 18 | 10,135 | 55 | 7.13 | 2.04 | 3.49 | 0.93 | 19.5 | 5.6 | 1.16 | .284 | 3.74 | 8.42 |
| 19 | | B. Witt | 1,955 | 430 | 142 | 157 | .475 | 397 | 4.83 | 47 | 11 | 0 | 2465.0 | 2,493 | 1,324 | 1,449 | 252 | 1,375 | 39 | 13 | 37 | 11,003 | 128 | 7.14 | 5.02 | 1.42 | 0.92 | 17.8 | 12.5 | 1.57 | .304 | 5.29 | 9.10 |
| 20 | | C. Hough | 1,949 | 539 | 179 | 181 | .497 | 439 | 3.88 | 107 | 13 | 5 | 3216.0 | 2,855 | 1,387 | 1,580 | 337 | 1,349 | 138 | 46 | 29 | 13,684 | 147 | 5.45 | 3.78 | 1.44 | 0.94 | 14.2 | 9.9 | 1.31 | .254 | 4.42 | 7.99 |
| 21 | | K. Appier | 1,948 | 393 | 162 | 129 | .557 | 381 | 3.67 | 34 | 12 | 0 | 2498.0 | 2,320 | 1,020 | 1,106 | 217 | 897 | 74 | 2 | 48 | 10,527 | 99 | 7.02 | 3.23 | 2.17 | 0.78 | 18.5 | 8.5 | 1.29 | .285 | 3.98 | 8.36 |
| 22 | | D. Darwin | 1,942 | 716 | 171 | 182 | .484 | 371 | 3.84 | 53 | 9 | 32 | 3016.2 | 2,951 | 1,286 | 1,432 | 321 | 874 | 81 | 171 | 101 | 12,716 | 52 | 5.79 | 2.61 | 2.22 | 0.96 | 15.3 | 6.9 | 1.27 | .277 | 4.27 | 8.80 |
| 23 | | B. Welch | 1,941 | 494 | 209 | 146 | .589 | 459 | 3.48 | 61 | 28 | 5 | 3059.1 | 2,867 | 1,183 | 1,302 | 267 | 1,030 | 79 | 14 | 60 | 12,830 | 54 | 5.71 | 3.03 | 1.88 | 0.79 | 15.1 | 8.0 | 1.27 | .273 | 3.83 | 8.43 |
| 24 | | D. Martinez | 1,939 | 620 | 223 | 176 | .559 | 523 | 3.63 | 112 | 29 | 4 | 3650.2 | 3,541 | 1,474 | 1,646 | 348 | 1,035 | 113 | 31 | 62 | 15,264 | 72 | 4.78 | 2.55 | 1.87 | 0.86 | 12.7 | 6.8 | 1.25 | .270 | 4.06 | 8.73 |
| 25 | | B. Blyleven | 1,866 | 389 | 156 | 132 | .542 | 385 | 3.73 | 106 | 22 | 0 | 2683.1 | 2,619 | 1,111 | 1,212 | 268 | 733 | 93 | 1 | 40 | 11,199 | 63 | 6.26 | 2.46 | 2.55 | 0.90 | 16.7 | 6.5 | 1.25 | .285 | 4.07 | 8.78 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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