Between June 1, 1966 and September 8, 1992, Nolan Ryan fanned the most hitters, with 5,659 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | N. Ryan | 5,659 | 792 | 319 | 287 | .526 | 758 | 3.18 | 222 | 61 | 3 | 5306.2 | 3,857 | 1,874 | 2,129 | 316 | 2,751 | 156 | 13 | 78 | 22,230 | 273 | 9.60 | 4.67 | 2.06 | 0.54 | 25.5 | 12.4 | 1.25 | .265 | 3.61 | 6.54 |
| 2 |  | S. Carlton | 4,115 | 726 | 329 | 244 | .574 | 707 | 3.22 | 254 | 55 | 2 | 5192.2 | 4,645 | 1,857 | 2,123 | 411 | 1,825 | 52 | 8 | 149 | 21,578 | 178 | 7.13 | 3.16 | 2.25 | 0.71 | 19.1 | 8.5 | 1.25 | .279 | 3.68 | 8.05 |
| 3 |  | B. Blyleven | 3,687 | 687 | 287 | 245 | .539 | 680 | 3.30 | 241 | 60 | 0 | 4939.0 | 4,590 | 1,812 | 2,009 | 427 | 1,320 | 152 | 3 | 71 | 20,356 | 113 | 6.72 | 2.41 | 2.79 | 0.78 | 18.1 | 6.5 | 1.20 | .282 | 3.66 | 8.36 |
| 4 |  | T. Seaver | 3,640 | 656 | 311 | 205 | .603 | 647 | 2.86 | 231 | 61 | 1 | 4783.0 | 3,971 | 1,521 | 1,674 | 380 | 1,390 | 76 | 6 | 117 | 19,369 | 125 | 6.85 | 2.62 | 2.62 | 0.72 | 18.8 | 7.2 | 1.12 | .259 | 3.15 | 7.47 |
| 5 | | D. Sutton | 3,512 | 763 | 318 | 252 | .558 | 745 | 3.27 | 176 | 57 | 5 | 5209.0 | 4,622 | 1,891 | 2,079 | 467 | 1,332 | 80 | 12 | 102 | 21,329 | 111 | 6.07 | 2.30 | 2.64 | 0.81 | 16.5 | 6.2 | 1.14 | .261 | 3.59 | 7.99 |
| 6 | | P. Niekro | 3,278 | 800 | 314 | 268 | .540 | 715 | 3.35 | 245 | 45 | 23 | 5294.0 | 4,933 | 1,968 | 2,276 | 474 | 1,764 | 117 | 56 | 79 | 22,187 | 214 | 5.57 | 3.00 | 1.86 | 0.81 | 14.8 | 8.0 | 1.27 | .269 | 3.87 | 8.39 |
| 7 | | F. Jenkins | 3,143 | 643 | 281 | 225 | .555 | 592 | 3.34 | 267 | 49 | 4 | 4446.0 | 4,101 | 1,650 | 1,833 | 476 | 984 | 83 | 24 | 114 | 18,180 | 62 | 6.36 | 1.99 | 3.19 | 0.96 | 17.3 | 5.4 | 1.14 | .269 | 3.71 | 8.30 |
| 8 | | G. Perry | 3,089 | 633 | 284 | 234 | .548 | 626 | 3.04 | 288 | 50 | 3 | 4772.1 | 4,372 | 1,613 | 1,866 | 349 | 1,213 | 94 | 7 | 132 | 19,509 | 136 | 5.83 | 2.29 | 2.55 | 0.66 | 15.8 | 6.2 | 1.17 | .272 | 3.52 | 8.25 |
| 9 | | F. Tanana | 2,643 | 602 | 231 | 217 | .516 | 580 | 3.61 | 142 | 34 | 1 | 3960.1 | 3,819 | 1,589 | 1,782 | 416 | 1,192 | 118 | 10 | 108 | 16,658 | 111 | 6.01 | 2.71 | 2.22 | 0.95 | 15.9 | 7.2 | 1.27 | .277 | 4.05 | 8.68 |
| 10 | | J. Koosman | 2,556 | 612 | 222 | 209 | .515 | 527 | 3.36 | 140 | 33 | 17 | 3839.1 | 3,635 | 1,433 | 1,608 | 290 | 1,198 | 71 | 43 | 121 | 15,996 | 89 | 5.99 | 2.81 | 2.13 | 0.68 | 16.0 | 7.5 | 1.26 | .282 | 3.77 | 8.52 |
| 11 | | M. Lolich | 2,257 | 455 | 174 | 161 | .519 | 398 | 3.45 | 170 | 31 | 4 | 2954.0 | 2,759 | 1,131 | 1,251 | 278 | 884 | 68 | 24 | 64 | 12,290 | 99 | 6.88 | 2.69 | 2.55 | 0.85 | 18.4 | 7.2 | 1.23 | .282 | 3.81 | 8.41 |
| 12 |  | J. Morris | 2,254 | 494 | 234 | 167 | .584 | 472 | 3.74 | 169 | 27 | 0 | 3494.0 | 3,184 | 1,451 | 1,586 | 356 | 1,248 | 50 | 10 | 94 | 14,633 | 177 | 5.81 | 3.21 | 1.81 | 0.92 | 15.4 | 8.5 | 1.27 | .264 | 4.09 | 8.20 |
| 13 | | V. Blue | 2,175 | 502 | 209 | 161 | .565 | 473 | 3.27 | 143 | 37 | 2 | 3343.1 | 2,939 | 1,213 | 1,357 | 263 | 1,185 | 23 | 11 | 61 | 13,838 | 103 | 5.85 | 3.19 | 1.84 | 0.71 | 15.7 | 8.6 | 1.23 | .263 | 3.65 | 7.91 |
| 14 | | C. Hough | 2,161 | 800 | 201 | 190 | .514 | 382 | 3.68 | 106 | 12 | 61 | 3463.1 | 2,945 | 1,415 | 1,617 | 344 | 1,538 | 156 | 240 | 40 | 14,700 | 159 | 5.62 | 4.00 | 1.41 | 0.89 | 14.7 | 10.5 | 1.29 | .248 | 4.20 | 7.65 |
| 15 | | L. Tiant | 2,115 | 503 | 204 | 154 | .570 | 431 | 3.34 | 164 | 40 | 12 | 3110.1 | 2,782 | 1,153 | 1,260 | 309 | 973 | 44 | 43 | 48 | 12,841 | 19 | 6.12 | 2.82 | 2.17 | 0.89 | 16.5 | 7.6 | 1.21 | .263 | 3.65 | 8.05 |
| 16 | | D. Eckersley | 2,101 | 728 | 181 | 145 | .555 | 361 | 3.44 | 100 | 20 | 230 | 2957.1 | 2,737 | 1,131 | 1,221 | 305 | 677 | 62 | 314 | 77 | 12,160 | 26 | 6.39 | 2.06 | 3.10 | 0.93 | 17.3 | 5.6 | 1.15 | .270 | 3.72 | 8.33 |
| 17 | | J. Palmer | 2,092 | 522 | 259 | 145 | .641 | 506 | 2.82 | 208 | 53 | 3 | 3792.2 | 3,226 | 1,189 | 1,318 | 289 | 1,224 | 36 | 8 | 36 | 15,459 | 79 | 4.96 | 2.90 | 1.71 | 0.69 | 13.5 | 7.9 | 1.17 | .249 | 3.13 | 7.66 |
| 18 | | R. Reuschel | 2,015 | 557 | 214 | 191 | .528 | 529 | 3.37 | 102 | 26 | 5 | 3548.1 | 3,588 | 1,330 | 1,494 | 221 | 935 | 88 | 16 | 117 | 14,888 | 89 | 5.11 | 2.37 | 2.16 | 0.56 | 13.5 | 6.3 | 1.27 | .290 | 3.79 | 9.10 |
| 19 | | T. John | 1,994 | 680 | 268 | 211 | .559 | 646 | 3.37 | 152 | 42 | 1 | 4342.1 | 4,448 | 1,627 | 1,871 | 275 | 1,135 | 92 | 17 | 89 | 18,159 | 172 | 4.13 | 2.35 | 1.76 | 0.57 | 11.0 | 6.3 | 1.29 | .285 | 3.88 | 9.22 |
| 20 | | J. Reuss | 1,907 | 628 | 220 | 191 | .535 | 547 | 3.64 | 127 | 39 | 11 | 3669.2 | 3,734 | 1,483 | 1,701 | 245 | 1,127 | 59 | 41 | 118 | 15,581 | 109 | 4.68 | 2.76 | 1.69 | 0.60 | 12.2 | 7.2 | 1.32 | .285 | 4.17 | 9.16 |
| 21 | | C. Hunter | 1,884 | 458 | 212 | 155 | .578 | 446 | 3.22 | 175 | 40 | 1 | 3243.1 | 2,788 | 1,159 | 1,283 | 349 | 874 | 46 | 4 | 50 | 13,174 | 45 | 5.23 | 2.43 | 2.16 | 0.97 | 14.3 | 6.6 | 1.13 | .243 | 3.56 | 7.74 |
| 22 |  | R. Clemens | 1,857 | 270 | 152 | 69 | .688 | 269 | 2.77 | 88 | 34 | 0 | 2011.2 | 1,677 | 620 | 691 | 128 | 545 | 51 | 0 | 34 | 8,133 | 48 | 8.31 | 2.44 | 3.41 | 0.57 | 22.8 | 6.7 | 1.10 | .279 | 3.09 | 7.50 |
| 23 | | B. Welch | 1,856 | 447 | 198 | 127 | .609 | 422 | 3.26 | 61 | 28 | 8 | 2837.1 | 2,592 | 1,029 | 1,140 | 231 | 926 | 70 | 16 | 53 | 11,803 | 51 | 5.89 | 2.94 | 2.00 | 0.73 | 15.7 | 7.8 | 1.24 | .271 | 3.62 | 8.22 |
| 24 |  | B. Gibson | 1,813 | 296 | 154 | 100 | .606 | 288 | 2.73 | 166 | 37 | 2 | 2342.2 | 1,967 | 711 | 794 | 134 | 732 | 48 | 4 | 76 | 9,573 | 58 | 6.97 | 2.81 | 2.48 | 0.51 | 18.9 | 7.6 | 1.15 | .268 | 3.05 | 7.56 |
| 25 | | R. Guidry | 1,778 | 368 | 170 | 91 | .651 | 323 | 3.29 | 95 | 26 | 4 | 2392.0 | 2,198 | 874 | 953 | 226 | 633 | 13 | 23 | 24 | 9,794 | 56 | 6.69 | 2.38 | 2.81 | 0.85 | 18.2 | 6.5 | 1.18 | .276 | 3.59 | 8.27 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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