Between September 15, 1971 and July 26, 1994, Nolan Ryan struck out the most batters, with 5,226 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | N. Ryan | 5,226 | 704 | 296 | 255 | .537 | 701 | 3.16 | 209 | 59 | 1 | 4884.0 | 3,562 | 1,713 | 1,955 | 287 | 2,461 | 135 | 3 | 65 | 20,393 | 255 | 9.63 | 4.54 | 2.12 | 0.53 | 25.6 | 12.1 | 1.23 | .267 | 3.60 | 6.56 |
| 2 |  | B. Blyleven | 3,367 | 631 | 265 | 226 | .540 | 626 | 3.33 | 224 | 56 | 0 | 4563.2 | 4,256 | 1,690 | 1,873 | 393 | 1,221 | 148 | 2 | 64 | 18,831 | 107 | 6.64 | 2.41 | 2.76 | 0.78 | 17.9 | 6.5 | 1.20 | .282 | 3.69 | 8.39 |
| 3 |  | S. Carlton | 3,201 | 555 | 254 | 183 | .581 | 541 | 3.25 | 190 | 40 | 1 | 3982.1 | 3,531 | 1,440 | 1,646 | 326 | 1,395 | 36 | 6 | 110 | 16,502 | 132 | 7.23 | 3.15 | 2.29 | 0.74 | 19.4 | 8.5 | 1.24 | .278 | 3.72 | 7.98 |
| 4 | | F. Tanana | 2,773 | 638 | 240 | 236 | .504 | 616 | 3.66 | 143 | 34 | 1 | 4188.1 | 4,063 | 1,702 | 1,910 | 448 | 1,255 | 129 | 10 | 116 | 17,641 | 119 | 5.96 | 2.70 | 2.21 | 0.96 | 15.7 | 7.1 | 1.27 | .277 | 4.10 | 8.73 |
| 5 |  | T. Seaver | 2,522 | 480 | 218 | 153 | .588 | 476 | 3.06 | 144 | 43 | 0 | 3437.2 | 2,899 | 1,168 | 1,283 | 285 | 1,045 | 49 | 1 | 87 | 14,009 | 94 | 6.60 | 2.74 | 2.41 | 0.75 | 18.0 | 7.5 | 1.15 | .259 | 3.36 | 7.59 |
| 6 | | P. Niekro | 2,475 | 590 | 239 | 204 | .540 | 562 | 3.49 | 173 | 29 | 7 | 4046.1 | 3,830 | 1,570 | 1,797 | 361 | 1,460 | 91 | 18 | 57 | 17,099 | 148 | 5.50 | 3.25 | 1.70 | 0.80 | 14.5 | 8.5 | 1.31 | .273 | 4.00 | 8.52 |
| 7 |  | J. Morris | 2,462 | 546 | 253 | 186 | .576 | 524 | 3.88 | 175 | 28 | 0 | 3809.0 | 3,546 | 1,642 | 1,799 | 388 | 1,376 | 57 | 10 | 99 | 16,041 | 204 | 5.82 | 3.25 | 1.79 | 0.92 | 15.3 | 8.6 | 1.29 | .269 | 4.25 | 8.38 |
| 8 | | D. Sutton | 2,450 | 552 | 244 | 172 | .587 | 548 | 3.24 | 124 | 40 | 2 | 3830.2 | 3,378 | 1,377 | 1,524 | 358 | 954 | 53 | 3 | 55 | 15,646 | 77 | 5.76 | 2.24 | 2.57 | 0.84 | 15.7 | 6.1 | 1.13 | .255 | 3.58 | 7.94 |
| 9 | | C. Hough | 2,350 | 846 | 216 | 216 | .500 | 440 | 3.74 | 107 | 13 | 59 | 3780.0 | 3,262 | 1,570 | 1,793 | 375 | 1,650 | 174 | 232 | 44 | 16,070 | 180 | 5.60 | 3.93 | 1.42 | 0.89 | 14.6 | 10.3 | 1.30 | .251 | 4.27 | 7.77 |
| 10 | | D. Eckersley | 2,240 | 843 | 187 | 153 | .550 | 361 | 3.47 | 100 | 20 | 291 | 3077.1 | 2,859 | 1,185 | 1,281 | 319 | 703 | 66 | 410 | 85 | 12,661 | 26 | 6.55 | 2.06 | 3.19 | 0.93 | 17.7 | 5.6 | 1.16 | .272 | 3.75 | 8.36 |
| 11 |  | R. Clemens | 2,185 | 323 | 172 | 91 | .654 | 322 | 2.93 | 94 | 36 | 0 | 2371.1 | 1,982 | 772 | 861 | 157 | 677 | 67 | 0 | 41 | 9,635 | 55 | 8.29 | 2.57 | 3.23 | 0.60 | 22.7 | 7.0 | 1.12 | .279 | 3.27 | 7.52 |
| 12 | | M. Langston | 2,089 | 349 | 150 | 132 | .532 | 346 | 3.72 | 76 | 17 | 0 | 2427.2 | 2,137 | 1,003 | 1,118 | 240 | 1,071 | 40 | 1 | 25 | 10,217 | 74 | 7.74 | 3.97 | 1.95 | 0.89 | 20.4 | 10.5 | 1.32 | .280 | 4.14 | 7.92 |
| 13 | | R. Reuschel | 2,015 | 557 | 214 | 191 | .528 | 529 | 3.37 | 102 | 26 | 5 | 3548.1 | 3,588 | 1,330 | 1,494 | 221 | 935 | 88 | 16 | 117 | 14,888 | 89 | 5.11 | 2.37 | 2.16 | 0.56 | 13.5 | 6.3 | 1.27 | .290 | 3.79 | 9.10 |
| 14 | | J. Koosman | 1,988 | 484 | 168 | 170 | .497 | 408 | 3.58 | 98 | 19 | 17 | 2953.0 | 2,880 | 1,175 | 1,309 | 226 | 925 | 56 | 42 | 81 | 12,379 | 62 | 6.06 | 2.82 | 2.15 | 0.69 | 16.1 | 7.5 | 1.29 | .289 | 3.99 | 8.78 |
| 15 | | B. Welch | 1,965 | 503 | 210 | 146 | .590 | 462 | 3.47 | 61 | 28 | 8 | 3087.1 | 2,888 | 1,189 | 1,308 | 267 | 1,031 | 79 | 19 | 60 | 12,934 | 55 | 5.73 | 3.01 | 1.91 | 0.78 | 15.2 | 8.0 | 1.27 | .273 | 3.81 | 8.42 |
| 16 | | G. Perry | 1,948 | 413 | 182 | 157 | .537 | 410 | 3.19 | 181 | 32 | 1 | 3082.2 | 2,892 | 1,093 | 1,240 | 235 | 803 | 58 | 3 | 76 | 12,635 | 81 | 5.69 | 2.34 | 2.43 | 0.69 | 15.4 | 6.4 | 1.20 | .277 | 3.62 | 8.44 |
| 17 | | D. Martinez | 1,915 | 580 | 218 | 170 | .562 | 498 | 3.64 | 116 | 25 | 6 | 3544.2 | 3,416 | 1,433 | 1,598 | 326 | 1,030 | 98 | 40 | 60 | 14,805 | 79 | 4.86 | 2.62 | 1.86 | 0.83 | 12.9 | 7.0 | 1.25 | .270 | 4.06 | 8.67 |
| 18 | | D. Gooden | 1,875 | 305 | 157 | 85 | .649 | 303 | 3.10 | 67 | 23 | 1 | 2169.2 | 1,898 | 747 | 823 | 123 | 651 | 41 | 1 | 31 | 8,898 | 47 | 7.78 | 2.70 | 2.88 | 0.51 | 21.1 | 7.3 | 1.17 | .286 | 3.41 | 7.87 |
| 19 | | F. Valenzuela | 1,849 | 370 | 150 | 130 | .536 | 358 | 3.45 | 112 | 31 | 2 | 2564.1 | 2,325 | 982 | 1,107 | 178 | 1,000 | 20 | 5 | 60 | 10,787 | 104 | 6.49 | 3.51 | 1.85 | 0.62 | 17.1 | 9.3 | 1.30 | .277 | 3.89 | 8.16 |
| 20 | | V. Blue | 1,825 | 448 | 183 | 152 | .546 | 427 | 3.38 | 117 | 27 | 1 | 2967.2 | 2,671 | 1,114 | 1,243 | 233 | 1,070 | 18 | 10 | 57 | 12,356 | 92 | 5.53 | 3.24 | 1.71 | 0.71 | 14.8 | 8.7 | 1.26 | .265 | 3.77 | 8.10 |
| 21 | | F. Viola | 1,822 | 412 | 175 | 146 | .545 | 411 | 3.67 | 74 | 16 | 0 | 2791.2 | 2,764 | 1,139 | 1,264 | 285 | 840 | 46 | 0 | 35 | 11,719 | 84 | 5.87 | 2.71 | 2.17 | 0.92 | 15.5 | 7.2 | 1.29 | .284 | 4.07 | 8.91 |
| 22 | | R. Guidry | 1,778 | 368 | 170 | 91 | .651 | 323 | 3.29 | 95 | 26 | 4 | 2392.0 | 2,198 | 874 | 953 | 226 | 633 | 13 | 23 | 24 | 9,794 | 56 | 6.69 | 2.38 | 2.81 | 0.85 | 18.2 | 6.5 | 1.18 | .276 | 3.59 | 8.27 |
| 23 | | F. Jenkins | 1,753 | 399 | 172 | 145 | .543 | 387 | 3.54 | 151 | 29 | 0 | 2784.1 | 2,669 | 1,095 | 1,220 | 317 | 630 | 55 | 7 | 62 | 11,484 | 34 | 5.67 | 2.04 | 2.78 | 1.02 | 15.3 | 5.5 | 1.18 | .269 | 3.94 | 8.63 |
| 24 | | F. Bannister | 1,723 | 431 | 134 | 143 | .484 | 363 | 4.06 | 62 | 16 | 0 | 2388.0 | 2,320 | 1,078 | 1,189 | 291 | 846 | 40 | 13 | 39 | 10,187 | 84 | 6.49 | 3.19 | 2.04 | 1.10 | 16.9 | 8.3 | 1.33 | .278 | 4.48 | 8.74 |
| 25 | | J. Reuss | 1,706 | 575 | 198 | 170 | .538 | 494 | 3.57 | 115 | 35 | 11 | 3334.1 | 3,388 | 1,324 | 1,525 | 222 | 973 | 51 | 41 | 105 | 14,108 | 94 | 4.60 | 2.63 | 1.75 | 0.60 | 12.1 | 6.9 | 1.31 | .284 | 4.12 | 9.14 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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