Between September 24, 1978 and April 20, 2006, Roger Clemens struck out the most hitters, with 4,502 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | R. Clemens | 4,502 | 672 | 341 | 172 | .665 | 671 | 3.12 | 118 | 46 | 0 | 4704.1 | 3,997 | 1,632 | 1,799 | 347 | 1,520 | 150 | 0 | 62 | 19,369 | 133 | 8.61 | 2.91 | 2.96 | 0.66 | 23.2 | 7.8 | 1.17 | .284 | 3.44 | 7.65 |
| 2 |  | R. Johnson | 4,390 | 527 | 265 | 138 | .658 | 517 | 3.12 | 97 | 37 | 2 | 3617.0 | 2,844 | 1,255 | 1,417 | 336 | 1,351 | 168 | 5 | 25 | 14,878 | 98 | 10.92 | 3.36 | 3.25 | 0.84 | 29.5 | 9.1 | 1.16 | .291 | 3.53 | 7.08 |
| 3 |  | G. Maddux | 3,066 | 646 | 321 | 189 | .629 | 642 | 3.01 | 108 | 35 | 0 | 4426.2 | 4,092 | 1,479 | 1,678 | 299 | 911 | 125 | 3 | 162 | 17,997 | 63 | 6.23 | 1.85 | 3.37 | 0.61 | 17.0 | 5.1 | 1.13 | .279 | 3.41 | 8.32 |
| 4 |  | N. Ryan | 3,047 | 448 | 175 | 147 | .543 | 448 | 3.26 | 71 | 24 | 0 | 2934.0 | 2,217 | 1,063 | 1,216 | 188 | 1,274 | 86 | 0 | 40 | 12,184 | 161 | 9.35 | 3.91 | 2.39 | 0.58 | 25.0 | 10.5 | 1.19 | .267 | 3.73 | 6.80 |
| 5 |  | P. Martinez | 2,878 | 422 | 200 | 84 | .704 | 355 | 2.73 | 46 | 17 | 3 | 2532.2 | 1,918 | 767 | 844 | 197 | 670 | 122 | 23 | 26 | 10,113 | 57 | 10.23 | 2.38 | 4.30 | 0.70 | 28.5 | 6.6 | 1.02 | .276 | 3.00 | 6.82 |
| 6 |  | C. Schilling | 2,855 | 518 | 196 | 131 | .599 | 385 | 3.38 | 82 | 19 | 22 | 2934.0 | 2,630 | 1,103 | 1,165 | 300 | 664 | 48 | 81 | 41 | 11,921 | 72 | 8.76 | 2.04 | 4.30 | 0.92 | 23.9 | 5.6 | 1.12 | .289 | 3.57 | 8.07 |
| 7 | | D. Cone | 2,668 | 450 | 194 | 126 | .606 | 419 | 3.47 | 56 | 22 | 1 | 2898.2 | 2,504 | 1,116 | 1,222 | 258 | 1,137 | 106 | 9 | 42 | 12,184 | 149 | 8.28 | 3.53 | 2.35 | 0.80 | 21.9 | 9.3 | 1.26 | .280 | 3.79 | 7.77 |
| 8 | | C. Finley | 2,610 | 524 | 200 | 173 | .536 | 467 | 3.85 | 63 | 15 | 0 | 3197.1 | 3,069 | 1,366 | 1,517 | 304 | 1,332 | 76 | 24 | 36 | 13,638 | 130 | 7.35 | 3.75 | 1.96 | 0.86 | 19.1 | 9.8 | 1.38 | .297 | 4.27 | 8.64 |
| 9 |  | J. Smoltz | 2,578 | 638 | 178 | 129 | .580 | 397 | 3.26 | 51 | 16 | 154 | 2950.1 | 2,556 | 1,069 | 1,166 | 235 | 888 | 41 | 204 | 68 | 12,081 | 131 | 7.86 | 2.71 | 2.90 | 0.72 | 21.3 | 7.4 | 1.17 | .278 | 3.56 | 7.80 |
| 10 | | M. Langston | 2,464 | 457 | 179 | 158 | .531 | 428 | 3.97 | 81 | 18 | 0 | 2962.2 | 2,723 | 1,306 | 1,438 | 311 | 1,289 | 46 | 3 | 34 | 12,562 | 89 | 7.49 | 3.92 | 1.91 | 0.94 | 19.6 | 10.3 | 1.35 | .285 | 4.37 | 8.27 |
| 11 | | M. Mussina | 2,423 | 447 | 226 | 128 | .638 | 447 | 3.63 | 56 | 23 | 0 | 3040.0 | 2,897 | 1,227 | 1,304 | 325 | 690 | 44 | 0 | 23 | 12,423 | 64 | 7.17 | 2.04 | 3.51 | 0.96 | 19.5 | 5.6 | 1.18 | .288 | 3.86 | 8.58 |
| 12 |  | J. Morris | 2,405 | 515 | 250 | 180 | .581 | 515 | 3.89 | 174 | 28 | 0 | 3677.1 | 3,428 | 1,588 | 1,740 | 378 | 1,320 | 55 | 0 | 94 | 15,486 | 199 | 5.89 | 3.23 | 1.82 | 0.93 | 15.5 | 8.5 | 1.29 | .269 | 4.26 | 8.39 |
| 13 | | K. Brown | 2,397 | 486 | 211 | 144 | .594 | 476 | 3.28 | 72 | 17 | 0 | 3256.1 | 3,079 | 1,185 | 1,357 | 208 | 901 | 139 | 1 | 42 | 13,542 | 108 | 6.62 | 2.49 | 2.66 | 0.57 | 17.7 | 6.7 | 1.22 | .290 | 3.75 | 8.51 |
| 14 | | T. Glavine | 2,376 | 607 | 277 | 185 | .600 | 607 | 3.43 | 55 | 24 | 0 | 3977.2 | 3,831 | 1,516 | 1,670 | 301 | 1,343 | 56 | 0 | 133 | 16,732 | 62 | 5.38 | 3.04 | 1.77 | 0.68 | 14.2 | 8.0 | 1.30 | .279 | 3.78 | 8.67 |
| 15 | | D. Gooden | 2,293 | 430 | 194 | 112 | .634 | 410 | 3.51 | 68 | 24 | 3 | 2800.2 | 2,564 | 1,091 | 1,198 | 210 | 954 | 78 | 4 | 42 | 11,705 | 76 | 7.37 | 3.07 | 2.40 | 0.67 | 19.6 | 8.2 | 1.26 | .288 | 3.85 | 8.24 |
| 16 | | D. Wells | 2,082 | 619 | 227 | 144 | .612 | 448 | 4.07 | 54 | 12 | 13 | 3210.1 | 3,347 | 1,453 | 1,571 | 377 | 666 | 80 | 65 | 60 | 13,417 | 100 | 5.84 | 1.87 | 3.13 | 1.06 | 15.5 | 5.0 | 1.25 | .291 | 4.40 | 9.38 |
| 17 | | F. Valenzuela | 2,074 | 453 | 173 | 153 | .531 | 424 | 3.54 | 113 | 31 | 2 | 2930.0 | 2,718 | 1,154 | 1,303 | 226 | 1,151 | 25 | 10 | 65 | 12,398 | 119 | 6.37 | 3.54 | 1.80 | 0.69 | 16.7 | 9.3 | 1.32 | .279 | 4.00 | 8.35 |
| 18 | | O. Hershiser | 2,014 | 510 | 204 | 150 | .576 | 466 | 3.48 | 68 | 25 | 5 | 3130.1 | 2,939 | 1,211 | 1,367 | 235 | 1,007 | 117 | 19 | 108 | 13,150 | 121 | 5.79 | 2.90 | 2.00 | 0.68 | 15.3 | 7.7 | 1.26 | .277 | 3.93 | 8.45 |
| 19 | | A. Benes | 2,000 | 403 | 155 | 139 | .527 | 387 | 3.97 | 21 | 9 | 1 | 2505.1 | 2,377 | 1,106 | 1,206 | 289 | 909 | 55 | 6 | 52 | 10,645 | 63 | 7.18 | 3.27 | 2.20 | 1.04 | 18.8 | 8.5 | 1.31 | .282 | 4.33 | 8.54 |
| 20 | | K. Appier | 1,994 | 414 | 169 | 137 | .552 | 402 | 3.74 | 34 | 12 | 0 | 2595.1 | 2,425 | 1,078 | 1,168 | 232 | 933 | 79 | 2 | 51 | 10,958 | 106 | 6.91 | 3.24 | 2.14 | 0.80 | 18.2 | 8.5 | 1.29 | .284 | 4.05 | 8.41 |
| 21 | | A. Leiter | 1,974 | 419 | 162 | 132 | .551 | 382 | 3.80 | 16 | 10 | 2 | 2391.0 | 2,152 | 1,010 | 1,101 | 198 | 1,163 | 117 | 9 | 53 | 10,334 | 63 | 7.43 | 4.38 | 1.70 | 0.75 | 19.1 | 11.3 | 1.39 | .284 | 4.14 | 8.10 |
| 22 | | B. Witt | 1,955 | 430 | 142 | 157 | .475 | 397 | 4.83 | 47 | 11 | 0 | 2465.0 | 2,493 | 1,324 | 1,449 | 252 | 1,375 | 39 | 13 | 37 | 11,003 | 128 | 7.14 | 5.02 | 1.42 | 0.92 | 17.8 | 12.5 | 1.57 | .304 | 5.29 | 9.10 |
| 23 | | D. Darwin | 1,941 | 714 | 171 | 182 | .484 | 371 | 3.84 | 53 | 9 | 32 | 3014.0 | 2,948 | 1,285 | 1,431 | 321 | 874 | 81 | 169 | 101 | 12,706 | 52 | 5.80 | 2.61 | 2.22 | 0.96 | 15.3 | 6.9 | 1.27 | .277 | 4.27 | 8.80 |
| 24 | | C. Hough | 1,928 | 519 | 177 | 179 | .497 | 439 | 3.88 | 107 | 13 | 2 | 3186.2 | 2,834 | 1,375 | 1,568 | 336 | 1,338 | 135 | 33 | 27 | 13,564 | 146 | 5.45 | 3.78 | 1.44 | 0.95 | 14.2 | 9.9 | 1.31 | .254 | 4.43 | 8.00 |
| 25 | | H. Nomo | 1,915 | 320 | 123 | 109 | .530 | 318 | 4.21 | 16 | 9 | 0 | 1972.0 | 1,758 | 923 | 984 | 248 | 904 | 38 | 0 | 31 | 8,435 | 109 | 8.74 | 4.13 | 2.12 | 1.13 | 22.7 | 10.7 | 1.35 | .283 | 4.49 | 8.02 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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