Between September 26, 1971 and August 11, 1994, Nolan Ryan fanned the most batters, with 5,221 strikeouts.
- Regular season
| NAME | SO | G | W | L | W% | GS | ERA | CG | SHO | SV | IP | H | ER | R | HR | BB | HBP | GF | IBB | TBF | WP | K/9 | BB/9 | K/BB | HR/9 | K% | BB% | WHIP | BABIP | RA | H/9 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | N. Ryan | 5,221 | 703 | 295 | 255 | .536 | 700 | 3.16 | 209 | 59 | 1 | 4876.0 | 3,555 | 1,711 | 1,951 | 287 | 2,455 | 134 | 3 | 64 | 20,354 | 254 | 9.64 | 4.53 | 2.13 | 0.53 | 25.7 | 12.1 | 1.23 | .267 | 3.60 | 6.56 |
| 2 |  | B. Blyleven | 3,349 | 628 | 262 | 226 | .537 | 623 | 3.34 | 221 | 55 | 0 | 4536.2 | 4,232 | 1,685 | 1,868 | 392 | 1,218 | 148 | 2 | 64 | 18,727 | 107 | 6.64 | 2.42 | 2.75 | 0.78 | 17.9 | 6.5 | 1.20 | .282 | 3.71 | 8.40 |
| 3 |  | S. Carlton | 3,193 | 552 | 253 | 182 | .582 | 538 | 3.25 | 189 | 39 | 1 | 3961.1 | 3,510 | 1,430 | 1,636 | 325 | 1,387 | 36 | 6 | 110 | 16,411 | 131 | 7.25 | 3.15 | 2.30 | 0.74 | 19.5 | 8.5 | 1.24 | .278 | 3.72 | 7.97 |
| 4 | | F. Tanana | 2,773 | 638 | 240 | 236 | .504 | 616 | 3.66 | 143 | 34 | 1 | 4188.1 | 4,063 | 1,702 | 1,910 | 448 | 1,255 | 129 | 10 | 116 | 17,641 | 119 | 5.96 | 2.70 | 2.21 | 0.96 | 15.7 | 7.1 | 1.27 | .277 | 4.10 | 8.73 |
| 5 |  | T. Seaver | 2,508 | 478 | 218 | 151 | .591 | 474 | 3.06 | 143 | 43 | 0 | 3421.2 | 2,889 | 1,164 | 1,279 | 283 | 1,040 | 48 | 1 | 87 | 13,949 | 94 | 6.60 | 2.74 | 2.41 | 0.74 | 18.0 | 7.5 | 1.15 | .259 | 3.36 | 7.60 |
| 6 |  | J. Morris | 2,478 | 549 | 254 | 186 | .577 | 527 | 3.90 | 175 | 28 | 0 | 3824.0 | 3,567 | 1,657 | 1,815 | 389 | 1,390 | 58 | 10 | 99 | 16,120 | 205 | 5.83 | 3.27 | 1.78 | 0.92 | 15.4 | 8.6 | 1.30 | .269 | 4.27 | 8.40 |
| 7 | | P. Niekro | 2,468 | 587 | 238 | 202 | .541 | 559 | 3.49 | 172 | 29 | 7 | 4026.2 | 3,814 | 1,561 | 1,787 | 359 | 1,458 | 91 | 18 | 57 | 17,022 | 148 | 5.52 | 3.26 | 1.69 | 0.80 | 14.5 | 8.6 | 1.31 | .273 | 3.99 | 8.52 |
| 8 | | D. Sutton | 2,428 | 549 | 242 | 171 | .586 | 545 | 3.24 | 122 | 39 | 2 | 3806.1 | 3,353 | 1,372 | 1,518 | 356 | 953 | 53 | 3 | 55 | 15,546 | 77 | 5.74 | 2.25 | 2.55 | 0.84 | 15.6 | 6.1 | 1.13 | .255 | 3.59 | 7.93 |
| 9 | | C. Hough | 2,350 | 846 | 216 | 216 | .500 | 440 | 3.74 | 107 | 13 | 59 | 3780.0 | 3,262 | 1,570 | 1,793 | 375 | 1,650 | 174 | 232 | 44 | 16,070 | 180 | 5.60 | 3.93 | 1.42 | 0.89 | 14.6 | 10.3 | 1.30 | .251 | 4.27 | 7.77 |
| 10 | | D. Eckersley | 2,245 | 849 | 188 | 153 | .551 | 361 | 3.46 | 100 | 20 | 294 | 3082.2 | 2,863 | 1,186 | 1,282 | 319 | 705 | 66 | 416 | 85 | 12,682 | 26 | 6.55 | 2.06 | 3.18 | 0.93 | 17.7 | 5.6 | 1.16 | .272 | 3.74 | 8.36 |
| 11 |  | R. Clemens | 2,201 | 326 | 172 | 93 | .649 | 325 | 2.93 | 94 | 36 | 0 | 2393.1 | 2,002 | 780 | 869 | 160 | 690 | 68 | 0 | 41 | 9,729 | 55 | 8.28 | 2.59 | 3.19 | 0.60 | 22.6 | 7.1 | 1.12 | .279 | 3.27 | 7.53 |
| 12 | | M. Langston | 2,110 | 352 | 151 | 134 | .530 | 349 | 3.74 | 77 | 17 | 0 | 2448.1 | 2,158 | 1,017 | 1,132 | 244 | 1,081 | 40 | 1 | 25 | 10,305 | 74 | 7.76 | 3.97 | 1.95 | 0.90 | 20.5 | 10.5 | 1.32 | .280 | 4.16 | 7.93 |
| 13 | | R. Reuschel | 2,015 | 557 | 214 | 191 | .528 | 529 | 3.37 | 102 | 26 | 5 | 3548.1 | 3,588 | 1,330 | 1,494 | 221 | 935 | 88 | 16 | 117 | 14,888 | 89 | 5.11 | 2.37 | 2.16 | 0.56 | 13.5 | 6.3 | 1.27 | .290 | 3.79 | 9.10 |
| 14 | | J. Koosman | 1,975 | 481 | 168 | 168 | .500 | 405 | 3.57 | 98 | 19 | 17 | 2938.2 | 2,859 | 1,166 | 1,300 | 223 | 920 | 56 | 42 | 81 | 12,312 | 60 | 6.05 | 2.82 | 2.15 | 0.68 | 16.0 | 7.5 | 1.29 | .288 | 3.98 | 8.76 |
| 15 | | B. Welch | 1,969 | 506 | 211 | 146 | .591 | 462 | 3.47 | 61 | 28 | 8 | 3092.0 | 2,894 | 1,191 | 1,310 | 267 | 1,034 | 79 | 20 | 60 | 12,956 | 55 | 5.73 | 3.01 | 1.90 | 0.78 | 15.2 | 8.0 | 1.27 | .273 | 3.81 | 8.42 |
| 16 | | G. Perry | 1,933 | 411 | 181 | 156 | .537 | 408 | 3.20 | 179 | 32 | 1 | 3064.2 | 2,884 | 1,091 | 1,237 | 234 | 799 | 58 | 3 | 75 | 12,571 | 81 | 5.68 | 2.35 | 2.42 | 0.69 | 15.4 | 6.4 | 1.20 | .278 | 3.63 | 8.47 |
| 17 | | D. Martinez | 1,923 | 582 | 219 | 171 | .562 | 500 | 3.63 | 117 | 26 | 6 | 3560.2 | 3,427 | 1,436 | 1,602 | 327 | 1,034 | 98 | 40 | 60 | 14,865 | 79 | 4.86 | 2.61 | 1.86 | 0.83 | 12.9 | 7.0 | 1.25 | .270 | 4.05 | 8.66 |
| 18 | | D. Gooden | 1,875 | 305 | 157 | 85 | .649 | 303 | 3.10 | 67 | 23 | 1 | 2169.2 | 1,898 | 747 | 823 | 123 | 651 | 41 | 1 | 31 | 8,898 | 47 | 7.78 | 2.70 | 2.88 | 0.51 | 21.1 | 7.3 | 1.17 | .286 | 3.41 | 7.87 |
| 19 | | F. Valenzuela | 1,861 | 373 | 150 | 130 | .536 | 360 | 3.44 | 112 | 31 | 2 | 2579.0 | 2,334 | 986 | 1,111 | 181 | 1,004 | 20 | 5 | 61 | 10,843 | 104 | 6.49 | 3.50 | 1.85 | 0.63 | 17.2 | 9.3 | 1.29 | .277 | 3.88 | 8.15 |
| 20 | | F. Viola | 1,822 | 412 | 175 | 146 | .545 | 411 | 3.67 | 74 | 16 | 0 | 2791.2 | 2,764 | 1,139 | 1,264 | 285 | 840 | 46 | 0 | 35 | 11,719 | 84 | 5.87 | 2.71 | 2.17 | 0.92 | 15.5 | 7.2 | 1.29 | .284 | 4.07 | 8.91 |
| 21 | | V. Blue | 1,819 | 446 | 183 | 152 | .546 | 425 | 3.38 | 117 | 27 | 1 | 2957.2 | 2,664 | 1,110 | 1,238 | 231 | 1,067 | 18 | 10 | 57 | 12,316 | 92 | 5.54 | 3.25 | 1.70 | 0.70 | 14.8 | 8.7 | 1.26 | .265 | 3.77 | 8.11 |
| 22 | | R. Guidry | 1,778 | 368 | 170 | 91 | .651 | 323 | 3.29 | 95 | 26 | 4 | 2392.0 | 2,198 | 874 | 953 | 226 | 633 | 13 | 23 | 24 | 9,794 | 56 | 6.69 | 2.38 | 2.81 | 0.85 | 18.2 | 6.5 | 1.18 | .276 | 3.59 | 8.27 |
| 23 | | F. Jenkins | 1,733 | 397 | 170 | 145 | .540 | 385 | 3.55 | 149 | 29 | 0 | 2766.1 | 2,656 | 1,092 | 1,215 | 317 | 629 | 54 | 7 | 62 | 11,413 | 34 | 5.64 | 2.05 | 2.76 | 1.03 | 15.2 | 5.5 | 1.19 | .269 | 3.95 | 8.64 |
| 24 | | F. Bannister | 1,723 | 431 | 134 | 143 | .484 | 363 | 4.06 | 62 | 16 | 0 | 2388.0 | 2,320 | 1,078 | 1,189 | 291 | 846 | 40 | 13 | 39 | 10,187 | 84 | 6.49 | 3.19 | 2.04 | 1.10 | 16.9 | 8.3 | 1.33 | .278 | 4.48 | 8.74 |
| 25 | | J. Reuss | 1,700 | 572 | 198 | 169 | .540 | 491 | 3.56 | 115 | 35 | 11 | 3324.2 | 3,374 | 1,314 | 1,515 | 221 | 966 | 49 | 41 | 105 | 14,057 | 93 | 4.60 | 2.61 | 1.76 | 0.60 | 12.1 | 6.9 | 1.31 | .284 | 4.10 | 9.13 |
StatMuse has game-level data for strikeouts going back to the 1901 season.
Some of the information used here was obtained free of charge from Retrosheet.
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